<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20056

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSEHSSKRQRLTGSFSPASPPYHASAKTDQTKPIVHPNTPTSPPYLPMNSQSHGAHTTSATAPGPDMTPPSSVHKSSHPHHSASSANNPMPFPTPASTTGVMSSSNLDSDGDALMDDPHDFSHRHSNHNRQSRDDVWSRRGGVAAAEGIFGSQLFKLCEKAPEVSRPHGSQNLIELYGLNKLANSVARNDPVTGEKINKLRKSYEGHIKLMKIAGKPKATKMEGMMTGLMQFPDFEYDMQKVNGKEIQGALTPDKSALSSRFDSLLNGAFAGMAPGPLPPHEASKFKAYMATDETVKAKGPDSMAERSAATTPNPANASAASRISRPERAGSKRQYNDSSFQGYGEGFTDDFGADSTGGEDNPQGNLAKKRRLAFERTSHQVEVGGVRR
Length389
PositionHead
OrganismCorynespora cassiicola Philippines
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Corynesporascaceae> Corynespora.
Aromaticity0.06
Grand average of hydropathy-0.837
Instability index48.64
Isoelectric point9.18
Molecular weight41849.96
Publications
PubMed=29551995

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP20056
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      97.46|      20|      23|      52|      71|       1
---------------------------------------------------------------------------
   26-   45 (29.59/12.34)	AKTDQT.KPIVHPNTPTSPPY
   52-   71 (36.92/17.25)	SHGAHT.TSATAPGPDMTPPS
   77-   97 (30.95/13.25)	SHPHHSaSSANNPMPFPTPAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      80.74|      18|      23|     260|     277|       2
---------------------------------------------------------------------------
  235-  253 (22.89/10.96)	FEYDmQKVNGKEIQGALTP
  260-  277 (30.31/16.59)	SRFD.SLLNGAFAGMAPGP
  284-  301 (27.53/14.48)	SKFK.AYMATDETVKAKGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.71|      20|      26|     138|     159|       3
---------------------------------------------------------------------------
  138-  159 (29.66/20.50)	SRRGGVAAAEGIFGsqLFKLCE
  165-  184 (34.05/18.16)	SRPHGSQNLIELYG..LNKLAN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.28|      28|      45|     302|     329|       4
---------------------------------------------------------------------------
  302-  329 (46.80/29.82)	DSMAERSAATTPNPANASAASRISRPER
  350-  377 (48.48/31.17)	DDFGADSTGGEDNPQGNLAKKRRLAFER
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20056 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HEASKFKAYMATDETVKAKGPDSMAERSAATTPNPANASAASRISRPERAGSKRQYNDSSFQGYGEGFTDDFGADSTGGEDNPQGNLAKKRRLAFERTSHQVEVGGVRR
2) MSEHSSKRQRLTGSFSPASPPYHASAKTDQTKPIVHPNTPTSPPYLPMNSQSHGAHTTSATAPGPDMTPPSSVHKSSHPHHSASSANNPMPFPTPASTTGVMSSSNLDSDGDALMDDPHDFSHRHSNHNRQSRDDVWSRRGG
281
1
389
142










Molecular Recognition Features






MoRF SequenceStartStop




1) FKAYMAT
2) NLAKKRRLAFERTSHQVEVGGVRR
3) YHASAKTDQTKPIVH
286
366
22
292
389
36