<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20052

Description Uncharacterized protein
SequenceMTSRPGPGIPESLHHRGTGALARGQVRRQPSKSNSIPPNVPVQDCIDPNLDPDRRPAEEAINKSRNPTSLKLKPAPLEALHTTATDTVRPPPRGRPQLFFSNVSSYGLDAPAQSPHSQHGNGPVNLPVPPRPGSTAPGDVSRQRRIIPGGTGVKSEVAVKPPATDAPAPALLFPGGKTADLFPWNGNNPEDTLSEAAVKAGFSNKPQIMNETNTARPSLWSNLKNKSGLSTLSSLFVAVLEKRQQCGRLTATNTFKPPPRLTLRDSTRETWLHDLANPAVGLRRLSRTIPHGITGKVLLDQCLNKNIPIPRAMWLAKCVGLNEMRSHKRKGQAGTITWMRGWTNSVEQFLDGTITTIGQSDWKPRITYALQLATQLYKEHLLEVEHFLDWLLKSLETSVPERLFLWLLLSSIYWTDLTSSRRRGRRLAEALVNHAEKLYRIEAETPVSPILEFLENTIMKLIITRPACLLLPRSWDKYSHVLETLSSRRAIPQVSRAIMDLDSRNKRLLRPSASTTASSRDSIGKVYQLLDSIDYGTSVRIGDIASDCMGLMSDTCSLISTVLRWASTLYREGSHRIYLVTRLLRKWSHFGVDVYDGILAHLNSVDFNGNSDPRAVFRVIAELVRSKTFSAGRYLQWLIATGSLGREQDLSLSSAWPLRLITEIPLSGLSEQIRNLRGTLLRGTIYSPEEEEKKLDFAEVIIQQQAPGLFGAGMAIDSHSDLDINSLSSTVKLELGVWLRYQVAATVEIMDRVPTKDPSIEESNAVCRISFHDFSVVRSYLEKFEDLSILADVIGIAASSLDSQVLASAADTLHYNYRAFRAIGAFEPLFEKIAMKYAAIRTVRFPERDLLVSLSDLASTARADGQLMQLLSYDMCRFDHKNSVAACSPVSDNMTDATQHPAVDSGDEIERILSSGTSMDQQIMSRVFNKMVRHLEEQLRKGQWELENHPIWFYRLRGFDEGMFDGVLTEWLTISLLNHKVDLLSAALPPLVASGSMTLSHFLDITKDCMKRTKTSHPAESVRIAIDGLNILIFPHNSQSPSPPQNSYRYRLEQFKLCRDSESNILEAIGELIQLSSNLSSIQQQQQVSALLSGSQLLAVLRQCAVRHVQVLATCIGVGQHSANESSKSYVKSVLDDLLDPRGFLDLNSKSPEQQVSSIVEAANELSLPFCQLEIQHIFSVESTTSENTADAISSALLHAVKTAVERDQPTWADLLSGLESSLMVKIREHAEREILSASAFLNNHSDSGLSNRDDRAFLQKYLTVIDFTSTDLPKDGQVSVIVPLIERLKGIAEALAKQGDSSKYNTHVQGCLAVPHLCAWLKAFLHLAGTQGTMVLSKVANQQQAALLWSLRCLFVQPVLEAFPSVAQHVFDVATLLSDNISDEVRNHLMRLDAVKSADDTRCAFIFGTAPPPDGWLTLTKPAHVAPPLQPTSTGTPHPQQSNTGHSPYQGNSNPSMQRSTSQQQSQSQSQAQIRGYSQYPQQNKIPQQLQRMPSNGAPSQLQQLQQMQQMQALAQQRNQQSSPAQMQRQPQTPMQANLPAKPGAIKQEKPDMRPTPFALRRWEILPDNGGNPLGNETAISLSLFGARKV
Length1591
PositionKinase
OrganismCorynespora cassiicola Philippines
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Corynesporascaceae> Corynespora.
Aromaticity0.06
Grand average of hydropathy-0.312
Instability index49.10
Isoelectric point8.55
Molecular weight176189.47
Publications
PubMed=29551995

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP20052
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     108.72|      15|      15|    1460|    1474|       1
---------------------------------------------------------------------------
 1460- 1474 (25.63/13.45)	R.....STSQ..QQSQSQSQAQ
 1476- 1492 (20.52/ 9.10)	R.....GYSQypQQNKIPQQLQ
 1493- 1511 (17.68/ 6.69)	RmpsngAPSQ..LQ.QLQQMQQ
 1513- 1527 (23.48/11.62)	Q.....ALAQ..QRNQQSSPAQ
 1530- 1543 (21.41/ 9.86)	R.....Q.PQ..TPMQANLPAK
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.19|      34|      36|     132|     167|       2
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  109-  164 (45.22/29.45)	DAPaqsphsqhgngpvnlpvpprPGSTAPGdvSRQRRIIP.GGTGVK...SEVAVKPPAT
  165-  203 (47.97/25.60)	DAP...................aPALLFPG..GKTADLFPwNGNNPEdtlSEAAVKAGFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.18|      26|      40|     268|     297|       3
---------------------------------------------------------------------------
  268-  297 (40.81/42.55)	RETWLhdlaNPAVGLRRLSRTIPHGITGKV
  311-  336 (47.37/36.24)	RAMWL....AKCVGLNEMRSHKRKGQAGTI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     169.56|      44|      44|     460|     503|       4
---------------------------------------------------------------------------
  441-  487 (66.93/45.74)	IEAETPVSPILEFLEN....................timKLIITRPACLLLPRSW.....DKYSHVLETLSS
  488-  532 (58.82/39.16)	RRAIPQVSRAIMDLDS....................rnkRLL..RPSASTTASSR.....DSIGKVYQLLDS
  538-  604 (43.82/26.99)	SVRIGDIASDCMGLMSdtcslistvlrwastlyregshrIYLVTR.....LLRKWshfgvDVYDGILAHLNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.22|      33|      35|     347|     381|       5
---------------------------------------------------------------------------
  347-  381 (48.99/47.24)	EQFLDGTITTIGQSdWKPRITYALqLATQLYKEHL
  385-  417 (59.23/45.03)	EHFLDWLLKSLETS.VPERLFLWL.LLSSIYWTDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.08|      25|      40|      28|      56|       6
---------------------------------------------------------------------------
   28-   56 (36.87/31.18)	RQPSkSNSIPPnVPVQ.......DCIDPnlDPDRRP
   65-   96 (41.21/20.23)	RNPT.SLKLKP.APLEalhttatDTVRP..PPRGRP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     626.62|     178|     258|     908|    1137|       7
---------------------------------------------------------------------------
  908- 1097 (272.33/221.90)	EIERILSSGTSMDQQIMSRVFNKMVRHLEEQLRKGQwELENHPIWFYRLRGFDEG....MF....DGVLTEWLTIS.LLNHKVDllSAALPPlvASGSMTLSHFLDItkdcMKRTKTSHPAE...SVRIA.IDGLNILIFPHNSQS...PSPPQNSY.RYRLEQFKLCRDSESnILEAIGelIQLSSNLSSIQQQQQVSALLSGSQL
 1174- 1355 (247.54/219.70)	EIQHIFSVESTTSENTADAISSALLHAVKTAVERDQ......PTWADLLSGLESS....LMvkirEHAEREILSASaFLNNHSD...SGLSN..RDDRAFLQKYLTV....IDFTSTDLPKDgqvSVIVPlIERLKGIAEALAKQG...DSSKYNTHvQGCLAVPHLCAWLKA.FLHLAG..TQGTMVLSKVANQQQAALLWSLRCL
 1357- 1451 (106.75/58.18)	.VQPVLEAFPSVAQH....VFD.VATLLSDNISD...EVRNHLMRLDAVKSADDTrcafIF.........................GTAPPP...DGWLTL.............TKPAHVAP...PLQPT.STGT.....PHPQQSntgHSPYQ.....................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.37|      25|      38|     617|     646|       9
---------------------------------------------------------------------------
  617-  646 (36.19/39.16)	FRVIAELVRSKTFSAGRYLQwliatGSLGR
  658-  682 (41.18/28.93)	LRLITEIPLSGLSEQIRNLR.....GTLLR
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20052 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MTSRPGPGIPESLHHRGTGALARGQVRRQPSKSNSIPPNVPVQDCIDPNLDPDRRPAEEAINKSRNPTSLKLKPAPLEALHTTATDTVRPPPRGRPQLFFSNVSSYGLDAPAQSPHSQHGNGPVNLPVPPRPGSTAPGDVSRQRRIIPGGTGVKSEVAVKPPATDAPAPALL
2) TLSEAAVKAGFSNKPQIMNETNTARPSLWSNL
3) WLTLTKPAHVAPPLQPTSTGTPHPQQSNTGHSPYQGNSNPSMQRSTSQQQSQSQSQAQIRGYSQYPQQNKIPQQLQRMPSNGAPSQLQQLQQMQQMQALAQQRNQQSSPAQMQRQPQTPMQANLPAKPGAIKQEKPDMRPTPFALRRWEILPDNGGNPLGNETAISLS
1
192
1417
172
223
1584










Molecular Recognition Features






MoRF SequenceStartStop




1) IKQEKPDM
2) LHHRGTGALA
3) PTPFALRRWEILP
1547
13
1556
1554
22
1568