<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20044
Description |
Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MNQNQHGKPGPKEMAVVEALRTRFMPTLYNIENLMREMSHNPTAPPEWTDLMRHHTLITNQINTIFTYINGPDQPTLSGPESHTQDLASLHPYPIPPFPLEQPPMAGLASTLLRKKLEPSSEDWINQRLAKAREFCNVPPEWDVPDLKAKDAAAGDDEDDEGAEVKRKVGSLDEDELAELWSAAAGVANERVQRFVAMYKQEAEEGDDEDEDEDEEMEDVIGGEQKGDGAAAAAAAAAKLPIMPLGAVHKFMSTGMVERPVGA |
Length | 263 |
Position | Head |
Organism | Corynespora cassiicola Philippines |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes>
Pleosporomycetidae> Pleosporales> Corynesporascaceae> Corynespora.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.637 |
Instability index | 44.01 |
Isoelectric point | 4.53 |
Molecular weight | 28964.05 |
Publications | PubMed=29551995
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP20044
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 196.72| 49| 49| 152| 200| 1
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114- 148 (47.37/20.45) ...............RKKLEPSSEDWINQRLAKAREFCNVPPEWDVPDLK
152- 200 (78.87/37.91) AAAGDDED.DEGAEVKRKVGSLDEDELAELWSAAAGVANERVQRFVAMYK
203- 250 (70.49/33.26) AEEGDDEDeDEDEEMEDVIGGEQKGDGAA..AAAAAAAKLPIMPLGAVHK
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 80.52| 28| 31| 18| 47| 2
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18- 47 (45.88/32.68) EALRTRFMPTlyN.IENLMREMS..HNPT.APPE
50- 81 (34.64/18.44) DLMRHHTLIT..NqINTIFTYINgpDQPTlSGPE
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