<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20043

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGRIMNHGADGATGPRDGDFKKRAYDGKMINGTPRKDTPTANGASAAPAVAQLPPEIQHLASEFYHPLSKLIVRIAQECYNDLTEVLQSMADMPVNPQANGVMANGLGSYGMANGGIDPEANKQKKLILMHFAQANRSKFIKLLVLLDWGKRSSVDVSKLIDLFQWMKDQSAQIDAVDVQLETMKVLSNYMREYNPDLRTSLEILGTGKAGWIPDMGFIPPEPISSEKALELLRYMNTALSIRLNVHETLPRHLRKWRIESGRATFVVDNEFEFDVISFADDLSDQWHFIDMRLLFTPAPSISTRSRFIGQLKRQADYILSQTGLTGCFDFLHKFILTHKITVLKSQAFELLRAGWAGSLKVEPVHRALVIQYWMDKPGRKNWIEIGISSNRPKDGKISWKGPPVSSLTVRWFRQGVEISDVDLAFDWKNLSLERMLKRVISLHIAHLLETARSNLSPKMRIKAEFSPEEPSECSLEAALGASADKTTLSMEPVTGRFILRPANHVSSQAEHFINARDPSHIGQMLMQLLARTLLDQIQRNAHQLGWLPMSRTEIGLDNVKQAVGRDILQFVLHYPRGWPGKWALATIIDASGESWWIVQMAHRGSGIVSAKQVEMHRPDGKTLPINRDFLSSMERVAAQLVAVTANQAKLDAEHQPYRIENEVATNPLSDAQVPLLHGWAIELRTCDLLESRPKGVQWLEPRMRLIFQRPRADKRNVWHIATGTVIKSEEAGLRKLVSASPQKNIGFSKSGEFYILLSSPFGESVVDELKARLRDVNRLRSFTTTLEKRKMVLRSSSLQEVRFQYGDNYTAAVNFGAESEIKLQLGQKNPHNRIHKFLTEIINDRCPKMLDGGITENSGLERFCTTLLLTRPIMTGLHEVESQEQSKGNYRNPTIHAHSIGQYRLTYQNPQCSFDIRLKPKDDKVVWSIEDNEKRAADFRPVAERSPSHKRLPKLKSALQQLFRESGESWFGVHSGIIAEMGSIPQVIKRLHETVIDCAAEEGQKPYEEVTASANAGGGNPTAPAGPRAPAPGQRPQAGDHRA
Length1045
PositionTail
OrganismCorynespora cassiicola Philippines
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Corynesporascaceae> Corynespora.
Aromaticity0.07
Grand average of hydropathy-0.395
Instability index47.43
Isoelectric point9.17
Molecular weight117372.04
Publications
PubMed=29551995

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP20043
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     450.04|     113|     167|     283|     398|       1
---------------------------------------------------------------------------
  170-  268 (133.20/92.84)	DQSAQIDAVDVQL..ETMKVL.......SNYMREYNPDLRTSLE.....................ILG.TGKAGWIPDM.GFIPPEPIS..SEKALELLRyM...NTALSIRLN.VHETLPrhLRKWRIESGRA.TFV.................
  283-  397 (186.74/145.22)	DLSDQWHFIDMRLLFTPAPSI.......STRSRFIGQLKRQADY.....................ILSQTGLTGCFDFLhKFILTHKITVlKSQAFELLR.A...GWAGSLKVEPVHRALV..IQYWMDKPGRK.NWI.....EIGISSNRPKDG
  424-  566 (130.10/83.88)	DLAFDWKNLSLERMLKRVISLhiahlleTARSNLSPKMRIKAEFspeepsecsleaalgasadktTLSMEPVTG......RFILRPANHV.SSQAEHFIN.ArdpSHIGQMLMQLLARTLL..DQ..IQRNAHQlGWLpmsrtEIGLDNVKQAVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.71|      23|     372|     583|     610|       2
---------------------------------------------------------------------------
  583-  610 (36.15/37.51)	KWALATIIDASGESWWIVqmaHrgSGIV
  958-  980 (44.56/28.37)	KSALQQLFRESGESWFGV...H..SGII
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     177.38|      46|      71|      27|      74|       3
---------------------------------------------------------------------------
   27-   74 (74.95/49.01)	DGKMINGTprKDTPTANGASAAPAVAQLPPEIQHLASEFYHPLSKLIV
  101-  146 (76.65/43.91)	NGVMANGL..GSYGMANGGIDPEANKQKKLILMHFAQANRSKFIKLLV
 1023- 1045 (25.78/ 9.30)	.............PTAPAGPRAPAPGQRPQAGDHRA............
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20043 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CAAEEGQKPYEEVTASANAGGGNPTAPAGPRAPAPGQRPQAGDHRA
2) MPGRIMNHGADGATGPRDGDFKKRAYDGKMINGTPRKDTPTANGASAAPA
1000
1
1045
50










Molecular Recognition Features






MoRF SequenceStartStop




1) FKKRAYD
2) PTAPAGPRAPAPGQRPQAGDHR
21
1023
27
1044