Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MDKFIDARFERVEKALATLIASISKYNPSPALAQDLVAADQELTDGLSLLSQHQQNTHTLASLQETSASLDAQIRDTLILLTSTRTALLETPASEFPEHTNQVEYGELLSYARRISKFTIPPDLRPGSKEDGDAKQDGSQTNGSATPTVTINTNGAANGNAMEVDLANPPNGANPPSAEPSSQPPPQSQTSLPAQDVQWLNTRNDYQPFVPWVREEELRRGALSSIEKLITAGIDPEGYDPDVEEQKKKEEAEEMERKAEEERVAEEEKRKAAEERRANAIASGGGHHGGSGGAPKPKVFQLEEFDDEDD |
Length | 310 |
Position | Middle |
Organism | Rutstroemia sp. NJR-2017a WRK4 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Rutstroemiaceae> Rutstroemia> unclassified Rutstroemia. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.822 |
Instability index | 52.20 |
Isoelectric point | 4.58 |
Molecular weight | 33813.58 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP20038 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 58.15| 18| 90| 23| 46| 1 --------------------------------------------------------------------------- 23- 46 (23.38/26.18) ISKYNPSPalaqDLVAADQEltDG 115- 132 (34.78/19.69) ISKFTIPP....DLRPGSKE..DG --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) KRKAAEERRANAIASGGGHHG 2) SGGAPKPKVFQLEEFDDEDD | 269 291 | 289 310 |
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