<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20037

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDLGEQLTNVLSCNNFASISYEYFEPQSPYFVSKKSLQNVEATWRSDGALVYFDSSRDGVWVFRPSPNSPSKPADEGFDLASDANLSNVPGIELSRRDRGTYEPANFARSRILGANSLGTPNTTSSPSAIDNMMRNAQSFNARAMQTNSSQTVYDLTASSPGVKSAVSAGDSSSSLREIQEHFIAAVLGSIVYNLCRDYGFVPLNSRTMIAPPDTSLSHDSTITLVTLDISLTSLGTLIIKAYSGNAPGLQRVVKSASLENTSKNLFRGTPLWLAPGGTPAKFYSFAEEDQFSGAQPMSDLQKAPEEHAWRFQGTTIKTWQSRCLEWLSTKGLDSSHLDEGGWIFVQMLKNDYVSVNQEYSDMPFSDDGAIVPWPVLLCFRSVRTSSTEMQSSSPSFYSIRDPLSFAEEWFTTEESRANLLAQRSNERQIVEATRKERAEKEAHNQANIHSANLLEKGNNAGAMYPTPPDGIQHLVVVTPSFDGAVSTPGNQPQLFAQDIEANNTTTSLMTTADIDHWGSTEAKHRPTSNMNFGENDNDNDNLFGDMGGDMFGDADITDADFNFFDQPDDIPMGLQPASPAIPPTIPTQQPRKPEKSSIPNKPAVFQPVSQDTEMKDLWLPDTSTKTFQNPGDPRNLPKEKATEPKTSNNNSQILPPPRIFVPFDKETVYRRLLQNITIPASPRSGKISSFNKVEFRDSLTSIMKKYESQGSFGYSEDDLMRHPVSLHNPTTPMSLDRRMTEKKTTTSDKLARILSGDTEPYDLPLGDEEPLELRHDSDSVSDASESDDALTIGLSMTSLSRKRKAYTEGAPTPSIVSFDAMDVDYEPSASTPQSVIEPQLPLFESDPADWSLTPYVTSPEPDVPPTGLSDHECIATAQILADQAASGSLRLPGQQEHTSNDPLEQLTATRRLMSGLSKATEKCFGDVQNCSMRSYLDIQGIPAINPALRLPPRPMPNPRAANPATPQRPSNIFLIPPPQLEVRRGDSKLAVLPPAIQFWDNLGLAPFTGGKDVNAVCIYPVIDGMAENADNFLDQMRGSYESLRFGFHDRLTSNDLPNGLLQFPIDGNNQANGMLNLTNLKEIMVRLSRILSILPVEEKNIVVYFIYPIDNSPLLVHICSAFKHLYNLYRKALLDKKQKAMTELVLQLVPINFVASPTSLVVPSPTEYSRLAMEVYDRCVDFTSFSSTSAILLERPLPKNIEFKLSANPSPSLLQENSCLHIAYAQSLDDRWITAAWSDNRGTKQMTASYCLGRKSEPLTLPFSHVANEIWETTLDVISSKKVHWRIVIVKSGAMDQSEIDFWTGLASTESNAQISLTLLTVQTDPSLHIIPPPLKLTPTSATTAQTVITPVSTPQASQSSLFSPDTPSREQPTTTAATPVEAPLTEPDNNSRLVDYTDQTWGAILSHRLNNSNSLLEFNPALISGYLIKNGGTTAEDPPVILEVNIIHAEVAGNPRTFHEGLLREILGYYRGLATLARVRGVVDPVRDGRPWHIAAAEKAVKALYTLL
Length1510
PositionKinase
OrganismRutstroemia sp. NJR-2017a WRK4
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Rutstroemiaceae> Rutstroemia> unclassified Rutstroemia.
Aromaticity0.08
Grand average of hydropathy-0.398
Instability index50.36
Isoelectric point5.02
Molecular weight166253.60
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20037
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      98.75|      20|      25|     820|     839|       1
---------------------------------------------------------------------------
  820-  839 (35.35/15.77)	DAMDVDYEP.SASTPQSVIEP
  847-  866 (38.07/17.55)	DPADWSLTP.YVTSPEPDVPP
 1333- 1352 (25.33/ 9.21)	.PPPLKLTPtSATTAQTVITP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     175.66|      49|     318|     606|     662|       2
---------------------------------------------------------------------------
  606-  662 (76.98/81.09)	FqPVSQDTEMKDlwlPdtstKTFQNPGDPRNLPKEKATEPKTSNNN..SQI..LPPPRIFV
  713-  755 (60.31/40.46)	F.GYSEDDLMRH...P....VSLHNPTTPMSLDR.RMTEKKTTTSDklARI..L.......
  953-  983 (38.36/18.96)	............................PRPMPNPRAANPATPQRP..SNIflIPPPQLEV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     162.00|      51|     466|     539|     591|       3
---------------------------------------------------------------------------
  539-  591 (89.25/63.52)	DNDNLFGDMGG.DMFG.......DADITDADfNFFDQ....PDDIPMGLQP..ASPAIPPTIpTQQP
 1001- 1065 (72.75/42.34)	DNLGLAPFTGGkDVNAvciypviDGMAENAD.NFLDQmrgsYESLRFGFHDrlTSNDLPNGL.LQFP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     454.84|     142|     265|      16|     169|       4
---------------------------------------------------------------------------
   16-  169 (219.39/153.69)	FASISYE.YFEPQSPYFVSKKSLQnvEATWRSDGALVYFDSSRDGVWvFrPSPNSPSKPADEG...F..DLASDANLSNVPGIELSRRDRGTYEPANFarsrILGANSLGTPNT...TSSPSAIDnmMRNAQSFNARAMQTNSSQTvyDLTASSPGVKSAVSA
  283-  433 (235.46/132.92)	FYSFAEEdQFSGAQPMSDLQKAPE..EHAWRFQGTTIKTWQSRCLEW.L.STKGLDSSHLDEGgwiFvqMLKNDYVSVNQEYSDMPFSDDGAIVPWPV....LLCFRSVRTSSTemqSSSPSFYS..IRDPLSFAEEWFTTEESRA..NLLAQRSNERQIVEA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.62|      26|     465|     204|     243|       5
---------------------------------------------------------------------------
  217-  243 (38.99/45.15)	LSHDS.TIT.......LVTLDISLTSLgTLIIKAY
  774-  807 (33.62/10.50)	LRHDSdSVSdasesddALTIGLSMTSL.SRKRKAY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20037 with Med13 domain of Kingdom Fungi
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