<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20033

Description Mediator of RNA polymerase II transcription subunit 7
SequenceMAEEQEQQQSNQAAAAFPAPPFFWQHFTPENVERIEKLRAAQSAKQDVTTETSSKLPPRILDLPKELRFLQPPDPPASGRYRSFGSAYTIQDELPSLETQGYDQLYTPPDTPTGTGKHADRALVLKRLAKSLLLNFLELLGIMSLNPEHAEEKIIDLRTLFINFHHLLNEYRPHQARESLILMMQDQLEKSRAETEGIMKMKEKVEGILEGLSEVKLEDKSAIEGQLHDEEPEDDGRDIWNQLEKEFG
Length248
PositionMiddle
OrganismRutstroemia sp. NJR-2017a WRK4
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Rutstroemiaceae> Rutstroemia> unclassified Rutstroemia.
Aromaticity0.07
Grand average of hydropathy-0.703
Instability index50.28
Isoelectric point4.90
Molecular weight28345.60
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. 

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20033
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.80|      20|      35|      55|      76|       2
---------------------------------------------------------------------------
   55-   76 (33.87/26.79)	KLPPriLDLPKELRFLQPPDPP
   93-  112 (37.93/23.37)	ELPS..LETQGYDQLYTPPDTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.06|      22|      25|     132|     155|       3
---------------------------------------------------------------------------
  132-  155 (31.80/27.92)	LLLNFLELLGimSLNPEHAEEKII
  160-  181 (40.26/27.72)	LFINFHHLLN..EYRPHQARESLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.49|      13|      14|     218|     230|       4
---------------------------------------------------------------------------
  218-  230 (22.22/13.09)	EDKSAIEGQLHDE
  234-  246 (24.27/14.83)	DDGRDIWNQLEKE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20033 with Med7 domain of Kingdom Fungi
Unable to open file!