<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20029

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMETESRNGSHTNHDRDRRNNRVNGEAFVSEKGQDKSQARTEPQKNMAPVSPSIPNGVNGNFRDKSAQQQDATEEAIPKELLERYNELPSEIDHITSGFIPLSDLLGRLSQVTHNKLGQRILEVAHMPLPPSATNGNASHITKDDDNSVDNLNKKLALIAFVQETHTKWVKALVITEWSKKAEDVSKIIDLRWYLEGNRKLYDAAVTSMVGVKKLLNSAKVPNPDFKTAIEVLTTGKANWMPDLGYIAPPPLTPKELLRSLEKLNTLLSIRLNIHERQAAELSRTTWIDGLKLEPLHRALCIQYWLDRYGKNGPRSWIILGVHSGRRKDGYHDPKATSRLFLRWFRDSKEVKDIDIPFDTVNISAEQLLKSVIALHTNHILSSTYNKLTSKPIFANREAGLSLTTSTEDPKESQLKLQLTEKQQITITIEPVMGRFIFSPASRMITSSEVKLNERSRDPASDAHSFIENLRCVSIAEELVSLGTSVGWQRVGHPRLSNEDLKPVIPKDTLQLTWFRRPGWREDWLIAVSLGMSGENWYLIELTKQPPTGVMKISSSIRIPIKGVSPTPTYTFMSSLHIFAGGLLSHFINLRALYKRRILHQVRSTGPPSSVRLPSVYIRLSDLLPSRGKSTSGKHWAHQNLKLTFQGLEPLLVTKPALPPSETPATQDPGTRPPQVPQIEQKATLVSEARLMIPISGLPILSERIDNDIAFHAKTGAFAFRLRSQVGESVIPSLIERLSQVERLVSFSAVICKHEKVLKCNSTSLKEITFSYGMATPDQSGTAMEVDNATSQSYKVTVDLSSMEGKMKLTLESGNPHIRVLDALDKVLNSSKGLDGVANLLPQTLYPLRAFDTIENAWGPLYTSGEVFVFVRAFEWYNLRYVLKSSTSNNPPRKIAFDIKMNHRRGVPWWFVRRNKGDKGDKREPPAEDEIDAQLKSVWNSSGPNWNGMRTSAVARYQGIEACLQKVDEVIRSISVDDLAPLPAQPPQSKGQAQTVGQQPGQNQQQMRLQQQARQLQLPTPGHSQPHSQGSSQGHQQRMPTPNMTMNMNMNMAMVQNQLKRKPSSQSVNPRGPKREVVEID
Length1080
PositionTail
OrganismRutstroemia sp. NJR-2017a BBW
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Rutstroemiaceae> Rutstroemia> unclassified Rutstroemia.
Aromaticity0.06
Grand average of hydropathy-0.504
Instability index48.50
Isoelectric point9.50
Molecular weight121107.79
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20029
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     157.58|      50|     364|     601|     678|       1
---------------------------------------------------------------------------
   88-  143 (78.17/33.39)	PSEIdHITSGFIPLSDLLGRLSQVTHNK.L..........GQRILEVAHMPLPPSATNGnashiTKD
  607-  667 (79.42/87.82)	PSSV.RLPSVYIRLSDLLPSRGKSTSGKhWahqnlkltfqGLEPLLVTKPALPPSETPA.....TQD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.65|      20|      20|     999|    1018|       3
---------------------------------------------------------------------------
  999- 1018 (36.26/24.63)	PGQNQQQMRLQQQARQLQLP
 1020- 1039 (39.40/27.50)	PGHSQPHSQGSSQGHQQRMP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     135.88|      43|     169|      45|      87|       4
---------------------------------------------------------------------------
   45-   87 (75.19/45.64)	NMAPV.SPSIPNGVNGNFRDKSAQQQD....ATEEAIPKEL...LERYNEL
  216-  266 (60.69/35.40)	NSAKVpNPDFKTAIEVLTTGKANWMPDlgyiAPPPLTPKELlrsLEKLNTL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20029 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ISVDDLAPLPAQPPQSKGQAQTVGQQPGQNQQQMRLQQQARQLQLPTPGHSQPHSQGSSQGHQQRMPTPNMTMNMNMNMAMVQNQLKRKPSSQSVNPRGPKREVVEID
2) METESRNGSHTNHDRDRRNNRVNGEAFVSEKGQDKSQARTEPQKNMAPVSPSIPNGVNGNFRDKSAQQQDATEEAIPKELLERY
973
1
1080
84










Molecular Recognition Features






MoRF SequenceStartStop




1) AFDIKMNHRRGVPWWFVRR
2) AMVQNQLKRKPSS
895
1052
913
1064