<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20016

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTASYCLGRKGEPLTLPFSHVANEIWETTLDVISSKKVHWRIVIVKSGAMDQSEIDFWTGLASTESNAQISLTLLTVQTDPSLHIIPPPLKLTPTSATTAQTVITPVSTPQASQSSLFSPDTPSREQPTATAATPVEAPLTEPDNNSRLVDYTDQTWGAILSHRLNNSNSLLEFNPALISGYLVKNGGTTAEDPPVILEGLGYAG
Length205
PositionKinase
OrganismRutstroemia sp. NJR-2017a BBW
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Rutstroemiaceae> Rutstroemia> unclassified Rutstroemia.
Aromaticity0.06
Grand average of hydropathy-0.151
Instability index38.48
Isoelectric point4.75
Molecular weight21969.41
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20016
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     112.18|      28|      30|      82|     110|       1
---------------------------------------------------------------------------
   61-   81 (24.86/ 9.23)	........LASTESNAQISLTLLTVQTDP
   82-  110 (43.84/25.19)	SlHIIPPPLKLTPTSATTAQTVITPVSTP
  115-  139 (43.48/21.23)	S.SLFSPD...TPSREQPTATAATPVEAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.82|      18|      18|     159|     176|       2
---------------------------------------------------------------------------
  159-  176 (31.03/21.53)	AILSHRL.NNSNSLLEFNP
  177-  195 (25.79/16.83)	ALISGYLvKNGGTTAEDPP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20016 with Med13 domain of Kingdom Fungi
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