<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20010

Description Transcription mediator subunit Med12 protein
SequenceMTTKPLVGSQAQRQSQSQSQRPLNTASIGRPSPHRSLSSTSASRRHNENTIDLTVDVPDFASARYGSSSRTGSRLKQELLNDPNGSGQSEIHGGGSSSLLFGRPPLPMRGRPQLHSDLQKSRPSNIGILPEQTHSHTPAKLMPLPVRPGRHPPPPIEKFSTSQTNHNKKDIRPKPYVLEVPAAAPSYTPNGHADFFPWHGNHPEDQFSESVIRQGFFDKTQMTQNETGTAKTSIYPSLKHKSGLQTLSSLFTSVLAQRRAHGNITANSTFKPPPRVTVTDTKREIWLKDLANPTISLRRLSRSIPHGIRGKVLLEHSLSKNIPIERAVWLAKCVGANELRSFRRKGASGAFAMGGETKWVRDFTVCVEQVLEGIIGSCGEKDFRRRINYAIRLAAHLHEECLLDREHYMDWILSSLESTSQSKLPMWLLIAQVYWKDILRHRRFGRRLAAALLARFSEATEHPDRDILGPLVDRLRLLLKDLLLSGPDNFLSPETWSKYGETLRLSLTGPDDSHLCAVWQELDHRNLRLTTLSSKSRHFSQQRLFRALDKVLSTTWTNDIVDVCWQLDNDKTILLHGALDWSTSSYRPGRAKVFIGARLLRSWSHLGVDVTAAVLSFIDASSCEVGRNKPAFYNLICELARSKDFCVSTYFQWLIGRGGIQAPTDLAPTGPCATRLLAEIPIHDLSEGMIALRKTLLLRAGYALDKEEEQIAKCIEIVKSSISEDLPAPHDESLQTRGQLEYIGSLLTGLTRAGKSELGCWLRDYSARRTQLTHSSLDSWPAPSMGRKSFCFNAIEFSFVRECLETIEDLAMLADVIKYVASSHDSQILSSCADTLNLHITSFAAIGVLKELFDTLVSRMQSLADDQDTIARGFLVSLVDLSTRIPNHQVISSQLSRQLSLSDKKHTADACSPVSDHMAGVLQNDEADFIDEIEKVLANGTSMDQGTMERLFHKVIGHWSSSWEKSLEQQRKCVQLLSGLRDFNAQSFDSLMTLWLSRILNLAVRPSMLQICGPLLGIGCLSIIDLSKICLRLVQHEVALERKIVGRLAMELLAILVRPLVLPGLLTRDETYRARLFQEHMLADSQILTLSIVRHAFEACSRSVDEELSILASRTSDLLTGAVMHELLQTLVLSSVESTTKTLVFPVLYGDNDKASTLLNAVINKLLDPAWPNEIPELPLEATLRLANDLTLPFCQLKVTSAFGSGDHVKINSQRLHSTIPFDDLNRAIDSVILSGDTTWTCIIPSLDLSVIQHLRRGTENQLLTMFHSIRASNFNDILQKDDQLARAESLLLILDLTISTISRKGPVSIQYLHNFFPDLIAILNGAWQFVANAHNTPLKAMFVSKWLPILLSFTGSQTAALEQSKLGHEHRGRILLVLTAIYLEMHILETNVEYHLESPLQKCYDLALHLVDVLPEDTRQQCIRSLRDVASSSKTSYIFSIMANSSDWLYISHGDRVAGTGKHSSLPNSEFSPEGTSQLIPFILKRWEMLGEPTPNMGENDTSLSLTLFASRRAID
Length1517
PositionKinase
OrganismRutstroemia sp. NJR-2017a WRK4
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Rutstroemiaceae> Rutstroemia> unclassified Rutstroemia.
Aromaticity0.07
Grand average of hydropathy-0.194
Instability index47.99
Isoelectric point7.79
Molecular weight169328.71
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20010
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     467.83|     153|     712|     412|     786|       1
---------------------------------------------------------------------------
  216-  384 (234.62/349.19)	FFDktqMTQNETGTAKTSIYPSLKH..KSGLQTLSSLFTSVLAQrrahGNITANSTFKPP.PrvTVTDTKREIWLKDLANPTISLRR..LSRSiphgirGKVL..LEHSLSKNIPIERAVwLAKCVGANELRSFRRKGAS...GAFAMG....GETK...WVRDFTVCVEQVLEGIIGSCGEKDFR
  617-  786 (233.21/178.23)	FID...ASSCEVGRNKPAFYNLICElaRSKDFCVSTYFQWLIGR....GGIQAPTDLAPTgP..CATRLLAEIPIHDLSEGMIALRKtlLLRA......GYALdkEEEQIAKCIEIVKSS.ISEDLPAPHDESLQTRGQLeyiGSLLTGltraGKSElgcWLRDYSARRTQLTHSSLDSWPAPSMG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     168.77|      44|      46|     511|     556|       2
---------------------------------------------------------------------------
  464-  496 (46.37/26.40)	D.............RDI.L...GPLVDRL......RLLLKDLLLSGPDNFLSpETW
  511-  556 (72.62/52.03)	DDSHLCavWQELDHRNLRL...TTLSSKS......RHFSQQRLFRALDKVLS.TTW
  559-  603 (49.77/28.96)	DIVDVC..WQLDNDKTILLhgaLDWSTSSyrpgraKVFIGARLLRS.........W
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     373.68|     128|     188|     792|     930|       3
---------------------------------------------------------------------------
  792-  930 (194.74/144.70)	F.NAIEFSfvRECletIEDLAMLADvikYVASSHDSQILSSCADTLNLHIT........SFAAIGVLK................ELFDTLVSR..MQSLA.DDQDTIARGFLVSLVDLSTRI.PNHQVISSQLsrqLSLSDKKHTADACSPVSDHMAGVLQNDEADFI
  963- 1119 (178.94/108.87)	WeKSLEQQ..RKC...VQLLSGLRD...FNAQSFDSLMTLWLSRILNLAVRpsmlqicgPLLGIGCLSiidlskiclrlvqhevALERKIVGRlaMELLAiLVRPLVLPGLLTRDETYRARLfQEHMLADSQI...LTLSIVRHAFEACSRSVDEELSILASRTSDLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.76|      40|      48|     102|     149|       4
---------------------------------------------------------------------------
  104-  143 (74.29/54.29)	PPLPMRGRPQLHSDLQKSRPSNIGI.LPEQTHSHTP...AKLMP
  154-  197 (63.47/28.07)	PPIEKFSTSQTNHNKKDIRPKPYVLeVPAAAPSYTPnghADFFP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20010 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ESVIRQGFFDKTQMTQNETGTAKTSIYPSL
2) MTTKPLVGSQAQRQSQSQSQRPLNTASIGRPSPHRSLSSTSASRRHNENTIDLTVDVPDFASARYGSSSRTGSRLKQELLNDPNGSGQSEIHGGGSSSLLFGRPPLPMRGRPQLHSDLQKSRPSNIGILPEQTHSHTPAKLMPLPVRPGRHPPPPIEKFSTSQTNHNKKDIRPKPYVLEVPAAA
209
1
238
184










Molecular Recognition Features






MoRF SequenceStartStop




1) FILKRWE
1483
1489