Description | Mediator of RNA polymerase II transcription subunit 19 |
Sequence | MPFDLPQTPQSPSYTPSATDSSSKATVSPRINTSLPTPAHSINGSMSSLNSAVEASQPDDLSNKRKRDVEDHGDRDQKKVHVEDSRLSINDLHQEVGQKYLLCRTQHPPLNTSVSQDLFDRFALNDIAASVARLLPDGKKNVIRKTYKGYIKSLGISGQFDAVRQEWEEDGSLFSLVNPEGPNPTKEIWEANHVRGQEIDKGLSDTVRSSLGRAMTMARGTIPKERWNSSVLGELGAANVDPSKQAAAKAKAPIMQGATSIPKANKAAAAAGAGAGAADIARPKRSVKKRTYGDASYEGYGEGYIDDDAGYSTGDGDDRAGGRKRPKKVGSLLYLLNIRANKQKTPTHSFQGPMRQSYGPGMVGA |
Length | 365 |
Position | Head |
Organism | Rutstroemia sp. NJR-2017a BBW |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Rutstroemiaceae> Rutstroemia> unclassified Rutstroemia. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.733 |
Instability index | 39.43 |
Isoelectric point | 9.30 |
Molecular weight | 39291.36 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP20009 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 52.11| 17| 19| 245| 263| 1 --------------------------------------------------------------------------- 245- 263 (24.29/17.37) QAAAKAKAPimQGATSIPK 266- 282 (27.82/13.70) KAAAAAGAG..AGAADIAR --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 54.51| 17| 21| 138| 154| 3 --------------------------------------------------------------------------- 138- 154 (28.78/18.63) GKKNVIRKTYK..GYIKSL 158- 176 (25.73/16.02) GQFDAVRQEWEedGSLFSL --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 67.60| 20| 21| 195| 214| 4 --------------------------------------------------------------------------- 195- 214 (32.82/22.08) RGQEIDKGLSDTVRSSLGRA 219- 238 (34.78/23.81) RGTIPKERWNSSVLGELGAA --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) AKAPIM 2) GRKRPKKVGSLLYLLNIRANKQKT | 250 322 | 255 345 |
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