<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20002

Description Transcription mediator subunit med12 protein
SequenceMTTKPLVGSQAQRQSQSQSQRPLNTASIGRPSPHRSLSSTSASRRHNENTIDLTVDVPDFASARYGSSSRTGSRLKQELLNDPNGSGQSEIHGGGSSSLLFGRPPLPVRGRPQLHSDLQKSRPSNIGILPEQTHSHTPAKLMPLPVRPGRHPPPPIEKFSTSQTNHNKKDIRPKPYVLEVPAAAPSYTPNGHADFFPWHGNHPEDQFSESVIRQGFFDKTQMTQNETGTAKTSIYPSLKHKSGLQTLSSLFTSVLAQRRAHGNITANSTFKPPPRVTVTDTKREIWLKDLANPTISLRRLSRSIPHGIRGKVLLEHSLSKNIPIERAVWLAKCVGANELRSFRRKGASGAFAMGGETKWVRDFTVCVEQVLEGIIGSCGEKDFRRRINYAIRLAAHLHEECLLDREHYMDWILSSLESTSQSKLPMWLLIAQVYWKDILRYRRFGRRLAAALLARFSEATEHPDRDILGPLVDRLRLLLKDLLLSGPDNFLSPETWSKYGEALRLSLTGPDDSHLCAVWQELDRRNLRLTTLSSKSRHFSQQRLFRALDKVLSTTWTNDIVDVCWQLDIDKTILLHGALDWSTSSYRPGRAKVFIGARLLRSWSHLGVDVTAAVLSFIDASSCEVGRNKPAFYNLICELARSKDFCVSTYFQWLIGRGGIQAPTDLAPTGPCATRLLAEIPIHDLSEGMIALRKTLLLRAGYALDKEEEQIAKCIEIVKSSISEDLPAPHDESLQTRGQFEYIGSLLTGLTRAGKSELGCWLRDYSARRTQLTHSSLDSWPAPSMGRKSFCFNAIEFSFVRECLETIEDLAMLADVIKYVASSHDSQILSSCADTLNLHITSFAAIGVLKELFDTLVSRMQSLADDQDTIARGFLVSLVDLSTRIPDHQVISSQLSRQLSLSDKKHTADACSPVSDHMAGVLQNDEADFIDEIEKVLANGTSMDQGTMERLFHKVIGHWSSSWEKSLEQQRKCVQLLSGLRDFNAQSFDSLMTLWLSRILNLAVRPSMLQICGPLLGIGCLSIIDLSKICLRLVQHEVALERKIVGRLAMELLAILVRPLVLPGLLTRDETYRARLFQEHMLADSQILTLSIVRHAFEACSRSVDEELSILASRTSDLLTSAVMHELLQTLVLSSVESTTKTLVFPVLYGDNDKASTLLNAVINKLLDPAWLNEIPDLPLEATLRLANDLTLPFCQLKVTSAFGSGDHVKINSQRLHSTIPFDDLNRAIDSVILSGDTTWTCIIPSLDLSVIQHLRRGTENQLLTMFHSIRASNFNDILQKDDQLARAESLLLILDLTISTISRKGPVSIQYLHNFFPDLIAILNGAWQFVANAHNTPLKAMFVSKWLPILLSFTGSQTAALEQSKLGHEHRGRILLVLTAIYLEMHILEKNVEYYLESPLQKCYDLALHLVDVLPEDTRQQCIRSLRDVASSSKTSYIFSIMANSSDWLYISHGDRVAGTGKHSSLPNSEFSPEGTSQLIPFILKRWEMLGEPTPNMGENDTSLSLTLFASRRAID
Length1517
PositionKinase
OrganismRutstroemia sp. NJR-2017a BBW
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Rutstroemiaceae> Rutstroemia> unclassified Rutstroemia.
Aromaticity0.07
Grand average of hydropathy-0.184
Instability index48.28
Isoelectric point7.93
Molecular weight169430.90
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20002
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     168.68|      44|      45|     484|     527|       1
---------------------------------------------------------------------------
  441-  479 (30.44/13.14)	............YRRFGRRLaaallaRFSeaTEHPDR.DILGPLVD.RL.RLLL
  484-  527 (78.92/46.36)	LSGPDNFLSPETWSKYGEAL......RLS..LTGPDD.SHLCAVWQ.ELDRRNL
  532-  574 (59.32/32.93)	LSSKSRHFSQQRLFRALDKV.......LS..TTWTNDiVDVC..WQlDIDKTIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     434.03|     145|     188|     772|     930|       2
---------------------------------------------------------------------------
  772-  930 (224.31/178.62)	LTHSSlDSWpAPSMGRKSFC.........FNAIEF.SFVRECLETIEDLAMLADVIkyvasshdsQI....LS.SCADTLNLHITSFAAIGVLKELFDTLVSR..MQSLA.DDQDTIARGFLVSLVDLSTRI.PDHQVISSQLsrqLSLSDKKHTADACSPVSDHMAGVLQNDEADFI
  956- 1119 (209.72/135.79)	IGHWS.SSW.EKSLEQQRKCvqllsglrdFNAQSFdSLMTLWLSRILNLAVRPSML.........QIcgplLGiGCLSIIDLSKICLRLVQHEVALERKIVGRlaMELLAiLVRPLVLPGLLTRDETYRARLfQEHMLADSQI...LTLSIVRHAFEACSRSVDEELSILASRTSDLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.38|      33|      40|      70|     109|       4
---------------------------------------------------------------------------
   73-  109 (52.22/38.59)	SRLKQELLND.PNGSG..QSEIHGGGSSSLLfgrpPLPVR
  112-  147 (52.16/22.49)	PQLHSDLQKSrPSNIGilPEQTHSHTPAKLM....PLPVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     124.67|      35|      40|     307|     345|       5
---------------------------------------------------------------------------
  282-  300 (21.50/ 8.89)	.......................KREIWLKDL..ANPTISLRRL
  307-  345 (55.65/50.99)	G...IRGkvllEHSLSKN..IPIERAVWLAKCVGANELRSFRRK
  349-  386 (47.52/33.38)	GafaMGG....ETKWVRDftVCVEQV..LEGIIGSCGEKDFRRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.17|      21|     117|      29|      51|       8
---------------------------------------------------------------------------
   29-   51 (33.38/30.24)	GR..PSPHRSLSSTSASrrHNENTI
  149-  171 (34.79/23.53)	GRhpPPPIEKFSTSQTN..HNKKDI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20002 with Med12 domain of Kingdom Fungi
Unable to open file!