Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MFSQFQASYQRIDASLQKLTDSIAAYNPSLAAADELVAADEAVKQNLEDLVRHQQNHLRIQELRATTESLDETIKTTLRLLAEARKDIASIPAIDTRPKDRKPQIDIHELLTYAKYIAPTTVPPTYRKPLKDDAQAQSKSTDPNSAAAAETTGDTTAQISNGLSTPQAEDQNPAFTKAEGNVGHKSLQEQDLAWLNPDLDADFQPWPNQYVMNRGALADVQKMVERGEDPKMKLSKEEQEIEDQRRAKEEEEAKARKAEEERRAKEMFGGHVQRRGTVVEGFNPDDL |
Length | 287 |
Position | Middle |
Organism | Cercospora berteroae |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Cercospora. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.885 |
Instability index | 44.05 |
Isoelectric point | 4.99 |
Molecular weight | 32165.30 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP19996 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 227.87| 73| 86| 123| 198| 1 --------------------------------------------------------------------------- 123- 198 (115.41/76.86) PPTY...RKPLKDDAQAQSKSTDPN...SAAAAETTGDTTAQISNGLSTPQAEDQNPAfTKAEGnvGHKSLQEQDLAWLNPD 207- 285 (112.46/65.30) PNQYvmnRGALADVQKMVERGEDPKmklSKEEQEIEDQRRAKEEEEAKARKAEEERRA.KEMFG..GHVQRRGTVVEGFNPD --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) PQIDIHELLTYAKYIAPTTV 2) RRAKEMF 3) YRKPLKD | 103 262 126 | 122 268 132 |
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