<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19993

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMMNQQGAVGSQDLKKDRSQAQTGNASQKRDLAQMQGAAHTNGNTNGVSSGSLPNGLPAKNELLPTSNGHSNGADTSVSRRSTPPPLDQSWRTSENNKPFGVLLARLAQQCFGDLNATLNKMNDMPSPQPAASNGVVPQTFDPSKESLARKKALMDFASDQRDRFTKALILSDFARSEHDMAKLVDLKAWFDSQIVAQDNAMRFIGITKHDVARAKMPNPNIEGAMELLANGKAPSKWPDLGYIPPPKLTAKQLASTLQDMNVIIATRLNLHEDLPHCFRDFSIANGRATFRVPGEFEVDLSVADEDPSSQFYLIDLRLSFTPAPELTDDLFRNALEAHTNEALSSKGLLGCYDFLHNFVLTHKINVLKSQSVRLFREKWFDCLVTETQRRVLAIQYWKDKAGKKSWIEFGISTGKSRSKHSRRKVTSQHSVRWFRQGQEVHDQAIFVDWDDLDLDAILSQVTAKHASWSLSTISDRLQALAGPRSQVRAQLSTSNSSADECNLTLSLPGLRNPIAVNIEPVTGLATISPSSKDAATAQRNLNRDPSADNSASIAQLLCRAVQDKVRRVAVSARWQLVDPRGFGPQPNFRALFGQDIVRHDIFACNEAWGERWSLCTTYSLAGQKWWVVQTSSRLVESRTIKTIVDARPLDVTTSALSRADLSRIQTMGEAEVSFAVLVQELGANKIPYHLERLSSLTFDGDRRDESATTVVYIRMSQQDLKKPELAPYKPLAITEWIRTVYEGFLDDNDGSGESRHDIRLTLESSQLKHLKDYLTTTQSRDGDVAMNASGGLALSLRAQFGQSYIKEIARLLKRCRELDSALSAARHLQYTCTAVGVSKLAFTYGTSQQYNGVLAKKGGSTELKLGPASSNPHQRIRTHLEEVYNRAADNPFFSLTFAMSATQPFLEAISELELKHSAQRTLTLHPHQVFSYSFVYHAPLAPCRFKIALHWNNQPTTRNKTVSYTATVWDRAGITLPAEFTTALTDLSKDAGSIAEGWMGNNRGGFTSNAKGLRAMLQRLDDFMLSSTNGTDNAVEKLDKSETPLPEAKPALNRNPSRTQAPTQQKPPIPAQMKNQARPPPHQMRPGQDSTARQMTVPATHGQRPNQNQGRVKKEIIELD
Length1120
PositionTail
OrganismCercospora berteroae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Cercospora.
Aromaticity0.07
Grand average of hydropathy-0.503
Instability index40.95
Isoelectric point9.15
Molecular weight124173.60
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19993
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     117.78|      28|      29|      39|      67|       1
---------------------------------------------------------------------------
   39-   66 (50.78/26.53)	HTNGNTNGVSSGSLPNGLPAKNELLPTS
   69-   93 (45.55/24.35)	HSNGADTSVSRRSTP...PPLDQSWRTS
  992- 1008 (21.45/ 7.83)	...........GSIAEGWMGNNRGGFTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.27|      21|      23|    1044|    1064|       2
---------------------------------------------------------------------------
 1044- 1064 (37.62/20.76)	PLPEAKPALNRNPSRTQAPTQ
 1068- 1088 (41.65/23.78)	PIPAQMKNQARPPPHQMRPGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     118.50|      29|      29|     153|     181|       3
---------------------------------------------------------------------------
  123-  148 (38.61/22.62)	..DMPSPQ.PAASNGVVPQTFD.P....SKESLA
  153-  181 (48.41/30.34)	LMDFASDQRDRFTKALILSDFA.R....SEHDMA
  183-  212 (31.48/16.99)	LVDL....KAWFDSQIVAQDNAmRfigiTKHDVA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.74|      18|      22|     628|     646|       4
---------------------------------------------------------------------------
  628-  646 (25.93/23.08)	VQTS..SRLVESRtIKTIVDA
  651-  670 (26.81/18.06)	VTTSalSRADLSR.IQTMGEA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.85|      15|      23|     450|     464|       5
---------------------------------------------------------------------------
  450-  464 (24.73/13.46)	DDLD.LDAILSQVTAK
  475-  490 (22.12/11.33)	DRLQaLAGPRSQVRAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.28|      18|      23|     329|     346|       7
---------------------------------------------------------------------------
  329-  346 (28.85/18.48)	DLFRNALEAHTNEALSSK
  353-  370 (30.43/19.87)	DFLHNFVLTHKINVLKSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.51|      11|      16|     275|     285|       8
---------------------------------------------------------------------------
  275-  285 (23.38/16.06)	PHCFR.DFSIAN
  293-  304 (16.13/ 8.65)	PGEFEvDLSVAD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.87|      27|      33|     544|     574|       9
---------------------------------------------------------------------------
  544-  574 (43.53/34.53)	DPSADNsasiAQLLCRAV..QDKVRR......VAVSARW
  578-  612 (44.33/26.10)	DPRGFG....PQPNFRALfgQDIVRHdifacnEAWGERW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      98.69|      28|      33|     919|     949|      10
---------------------------------------------------------------------------
  893-  914 (18.72/ 6.26)	...........FSLT.FAM.SAtqPFL.EAISELEL
  919-  949 (45.24/37.70)	QRTLTlhpHQVFSYS.FVY.HA..PLA.PCRFKIAL
  954-  984 (34.73/19.94)	QPTTR...NKTVSYTaTVWdRA..GITlPAEFTTAL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19993 with Med14 domain of Kingdom Fungi
Unable to open file!