<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19991

Description Uncharacterized protein
SequenceMDHGHRPLGGGTGQRPLPPQRAVSGSHALQQGLKRPAVPSRLNNVRSVSQPGFYVDWTADAATRQNVAAFTNNGGSLYTSPNVIDLSDDDQARPAKRARTDAHVPAPGDGGVQDPAHRRRPGSPLPTPPVPRLPACMGRSRRPVVDRMARRANGLEPPQCATRLPLPKQVADFAPWNGQHPEDVMTDGVVKAGYYDKPPGPNSTETNSAKPTIWPNLSAKNNMGLQTLSYLFTSVLEKRQALGKCTAPSTFKPPPRVTVTDTKREAWLRDLANPEVPLRKQSRTIPHGIRGKLLMEQCLGKNIAMPRAVWLAKCVGANELRAFRRKGVSGTAAAAGESKWVREWTVQVEHFLESVIAMCGLPEWQSKMDYAVKLATAFYAERLLERDHYLDWIVSSYAQATTDRLPIWIILVQLYWKEITSFGRRGRRLAEATLENLQQLTRLDSRVHDSLKARLQKLVMIMAVTNRGCLIIPKSWQKYQHLLTPKTAALGTPAQNITGRNRRLLAPLMKTPQNTRCPLLTLYGILDAHAHALHVDVERLATACQAIIPEIDKLIAALLTWSSSVYRTGVNRAYLAAKVIAVLGSKGLDTDGAILSFLGCPQSASIVAADVHRVLTELVRENGFSCGRYLQWLITSGAVSGSASPDLATGLLIALPASALPAHLQNTRRSLLHRITDVKDEGSLVSEILGVGIDDSDTASRARVIQQTESLGAAAKQELADALTAQVEYRVKESILTHAWFCFARDVLEIILDMRALCHLLQMSMASGDPGILASISDTIDYHRKSFAAMGYLMPMVDDLLEHYRVLRSQQALDRALIMSLITLTKPWADKMHLLQSQQILSALPNDLLICEQQTSMAVCSPASDSLVSMQVGSLDSDQEIDAVFASGNTMDEQLMQRVFARIAQRASKFESEQDHAASKLCAWLTQLRAVDATNFELLATSHVQTCLRSSGDPASSLTLISALVANGCMELETVVGLAQNMKTPASACTMVRLLTATASICVGLGEHEAYRFRVIQQRACQTSADTLVPLLITAMDDTKFPASDPGIITLLLEYTVSRYHVCLRALTSARPSPAFLVNCTKLVTRMLSPSCDEYVPVVGLEAKTIISLADAISVAQCTMALALLAKKEALRGSPNESTLQPAILDAIINGSEIWPQLLESAGQDTVRSIYQWAKDQVLVCTSLETGPASIDEAQASRNLDILCVAHHAVKDHSKTQIVSGILDRLKELLERLPKEPLGAEHKQYLMALRILLHLSILYACDPSSDHDGPRTSRESLLATLCIFLGHPGLQCHQEILEYIHDVASALSDALPPESLTALGHAMLRNGVRDPRLAFILGMINNPDAWLALVSYPQPQPGGGSAQAKALLQRAAQQQQQAQAAGRPGPMSGAGGSAVLQRAMSIRAGQQPQGEPKVVPYTLRRWEMMSDATPSMGDNDTSLSLGLFGARKVY
Length1450
PositionKinase
OrganismCercospora berteroae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Cercospora.
Aromaticity0.05
Grand average of hydropathy-0.110
Instability index48.63
Isoelectric point8.62
Molecular weight158056.08
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19991
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     148.44|      45|      72|     498|     542|       1
---------------------------------------------------------------------------
  498-  528 (45.02/22.19)	.......................................TGRN.R.....RLLAPLMKTP..QNTRCPLLTLYGILDA
  529-  602 (50.06/25.47)	HAHALHVDVERLATacqaiipeidkliaalltwsssvyrTGVN.RaylaaKVIAVLGSKG..LDTDGAILSFLGC.PQ
  603-  654 (53.37/27.63)	SASIVAADVHRVLT....................elvreNGFScG.....RYLQWLITSGavSGSASPDLAT.GLLIA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.05|      19|      25|    1366|    1384|       2
---------------------------------------------------------------------------
 1366- 1384 (30.23/14.96)	ALLQRAAQQQQQAQAAGRP
 1394- 1412 (34.83/18.35)	AVLQRAMSIRAGQQPQGEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.88|      20|      29|      94|     122|       3
---------------------------------------------------------------------------
   83-  105 (22.23/13.29)	VIDLSDDDQARPAkrARTDAhVP
  112-  131 (38.65/26.36)	VQDPAHRRRPGSP..LPTPP.VP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.76|      13|      28|     954|     966|       4
---------------------------------------------------------------------------
  954-  966 (21.08/11.86)	PASSLTLISALVA
  985-  997 (23.69/14.29)	PASACTMVRLLTA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     126.78|      29|      72|     242|     270|       5
---------------------------------------------------------------------------
  242-  270 (51.20/28.67)	LGKCTAPSTFKPPPRVTVTDTKREA....WL.RD
  271-  297 (35.96/17.94)	LANPEVP..LRKQSR.TIPHGIRGK....LLmEQ
  311-  343 (39.62/20.52)	LAKCVGANELRAFRRKGVSGTAAAAgeskWV.RE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     102.39|      27|      28|     793|     819|       6
---------------------------------------------------------------------------
  793-  819 (46.97/30.41)	LM....PMVDDLLE.HYRVLRSQQ...ALDRALIM
  821-  850 (30.44/16.90)	LItltkPWADKM...H..LLQSQQilsALPNDLLI
  860-  882 (24.98/12.44)	CS....PASDSLVSmQVGSLDSDQ...EID.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     218.00|      70|      75|    1168|    1240|       7
---------------------------------------------------------------------------
 1168- 1240 (111.47/91.98)	RSIYQWAKdQVLVCTSL..ETGPAS.IDEAQASRN..LDILCV..AHHAVKDHSktQIVSGILDRLKELLERLPKEPLGA
 1242- 1318 (106.53/76.39)	HKQYLMAL.RILLHLSIlyACDPSSdHDGPRTSREslLATLCIflGHPGLQCHQ..EILEYIHDVASALSDALPPESLTA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.06|      20|      23|     136|     157|       8
---------------------------------------------------------------------------
  136-  157 (33.58/24.74)	CMGRSRRP..VVDRMArrANGLEP
  160-  181 (36.48/20.39)	CATRLPLPkqVADFAP..WNGQHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.57|      17|      23|       4|      21|       9
---------------------------------------------------------------------------
    4-   21 (30.30/20.03)	GHRPLGGGTgQRPLPPQR
   25-   41 (31.27/15.79)	GSHALQQGL.KRPAVPSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     208.88|      64|     410|     661|     736|      17
---------------------------------------------------------------------------
  658-  722 (99.45/72.62)	SALPAHLQNTRRSLLHRITDVKDEGSLVSEILGVGIDDSDTASRARVIQ.QTESLGAaAKQELADA
  734-  789 (81.51/75.34)	SILTHAWFCFARDVLEIILDMRALCHLLQMSMASG.DPGILASISDTIDyHRKSFAA.........
 1003- 1027 (27.91/10.54)	.................................VGLGEHE.AYRFRVIQ.QR......ACQTSADT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19991 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGSAQAKALLQRAAQQQQQAQAAGRPGPMSGAGGSAVLQRAMSIRAGQQPQGEPKVVPYTLRR
2) MDHGHRPLGGGTGQRPLPPQRAVSGSHALQQGLKRPAVPSRLNNVRSVSQPGFYVDWTAD
3) RQNVAAFTNNGGSLYTSPNVIDLSDDDQARPAKRARTDAHVPAPGDGGVQDPAHRRRPGSPLPTPPVPRLPACMGRSRRPVVDRMARRANGLEPPQCATRLPLPKQVADFAPWNGQHPEDVMTDGVVKAGYYDKPPGPNSTETNSAKPTIWPNLS
1359
1
64
1421
60
218










Molecular Recognition Features






MoRF SequenceStartStop




1) YTLRRW
1417
1422