<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19982

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFLKACTTNIHAIESVSQVRFALFQFRHHTAPSHTQWSKLQRAIARLRADNVLCAAVGLQLYVFGDSAGDSNDAYQELEADFEVIAKGTVAERAAEPATSSPRDALLAAVELSIAHNLSKDPAITHVAPWTWLYGNRRGDEVDEGESMMIKLRARTTSTDGLYLVSDVLPATLQAVGSARRSTDDLLVLAPFGQSARPLVLDSGKNLLDGENWRTIVAEMLPTQGLELPRDTQWIPVELLDGTGNAWAWPAHLCFTTSAPNNQVDATIAESRDWRRWFISTEEGAIFRNPLAVTEEWYKGFAARERAKADADVFVPTEAPTTGQAPPTMTAEVTPLEADTAVSPSFTQRGAEHLSAMVGIYPTPPDGFAPAQPGLLSAATPSVTQPDPSSSVLGTSPNDSMQPKPPAQHPPPPHDPSESNAAQDDLFGDVGEMGFGDAEIEDADFNFFDEPDDEFTEQPPMETRDVLEESNADTEMISAAQPTELALEGDASVLPDASNDADLLQYELADTTHASIAEKVDTEEDPIGARALSEPSIKPKRPLSPFGIREKLLPPPVPASHSQVHADAQSRHMGRRDSSFASINFRNSIRMASMYEPALVAKDAARAKPPSDSVCITLPPARTGPGVKQAVHDTDGCDDDSSDSEEESYESSSSEASDSNLPPSLPWETRKRKRQLDDDVATYTSNDHMSSYAEEDEVGNVSDAVARDTMVEVLQQYSSSILLTDFVSSLRPSKHTQRPPALHHALQPESMETVAGPLPSLESAYTLTKSDLICVAQLVADQSITANARSSIGVHDPSGDSELIAPVVTKYLRDQLKRAVRIAVPEALECDLSELALSKESVLRQTNNAGKTSQGQPRPPQRLDSAHVGPDCFTLPSPFLRLRRGRDAWEMLPACIPFWETLGLSPAAGPKHLRAFCVFPFNEDLQRLADHFLGDLGTAYENCKLGTHVHLRNVSEMDVHDTFEDGMAPVDLGEEASLEAALKSYATTCSDLGKALSTIVHQESEDRAIVVYILNPFSGEEARQHLCACFWTLFQTYRDNMPRAPGERGGSDIFLQLLPISLVAAYDAFVPLDARRMSILAREIYDRCPPTSALQLSDISAPLPNLAAPTVELASMAPKRLGFQLIPEAAADLLYEGSILHLAYACSSDGKWLTASWIDSTGKYQSSSSFCMVGKTFAETAEDVWEHTKSIMAARQVSWRIFVVTQDNAIETSVMHCWRMLAAKPRAQPVCVTMLSIQSEPLLQLLPPYAGLEHAAIGSAENGVLTPASTPQGTTFTSSPDVAGHGGNTPLTPAPSDTATSLPADSAADADAQLTDMTDETWGVLLTSKLSGTTQNSSMAHGVLLQRGKVALHDTDQIEMIDRLPSLGVNIHWTIQVKPQGTVDEGSIKQAELTLREVLRMFRGLSLLTKARGLECSVGAFAPLHVATAVMGAAGLDGFLADPEGESG
Length1449
PositionKinase
OrganismCercospora berteroae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Cercospora.
Aromaticity0.06
Grand average of hydropathy-0.277
Instability index48.30
Isoelectric point4.71
Molecular weight156708.65
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19982
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     580.36|     127|     156|     320|     475|       1
---------------------------------------------------------------------------
  322-  448 (212.84/94.51)	..........T..TGQAPPTMTAEVTPLEA.DTAVS...................PS.FTQRGAEHL...SAMVGIYPTPPDGFAPAQPGLLSAATPSV.....TQPDPSSSVLG....TSPNDSMQPKPPAQHP........PP.PHDPSESNAAQDDLFGDVGEMGFGDAEIedADFNF
  465-  586 (122.67/75.69)	RDvleesnadTemISAAQPTELA....LEG.DASVL...................PD..ASNDADLL....................QYELADTTHASIaekvdTEEDP....IGaralSEP..SIKPKRPLS.PfgirekllPP.PVPASHSQ.VHAD..AQSRHMGRRDSSF..ASINF
  587-  689 (133.55/50.52)	RN........................SIRM.ASMYE...................PA.LVAKDAARAkppSDSVCI.TLPP...ARTGPGVKQAVHDTD.....GCDDDSSDSEE....ESYESSSSEASDSNLP........PSlPWETRKRKRQLDD...DVATYTSNDH.........
  691-  808 (111.29/40.05)	.............SSYAEEDEVGNVSDAVArDTMVEvlqqysssilltdfvsslrPSkHTQRPPALH...HAL...QPESMETVAGPLPSLESAYT..L.....TKSD.LICVAQ....LVADQSITAN..ARSS........IG.VHDPS....GDSELIAPV.................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.46|      13|      16|    1067|    1081|       2
---------------------------------------------------------------------------
 1067- 1079 (24.21/14.56)	YDAFVPLDARRMS
 1086- 1098 (25.25/ 8.96)	YDRCPPTSALQLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      65.13|      18|     156|     980|    1011|       3
---------------------------------------------------------------------------
  980-  997 (30.73/10.41)	EAALKSYATTCSDLGKAL
 1137- 1154 (32.18/11.71)	EGSILHLAYACSSDGKWL
 1176- 1184 ( 2.22/17.53)	....KTFAETAED.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     255.06|      82|     125|      62|     186|       4
---------------------------------------------------------------------------
   46-  144 (116.71/118.59)	ARLRADNvlcaavglqLYVFGDSAGD.SNDAYQELeADFEvIAKGTVAERAAEPATSSPRDALLAAVE.LSIAHNLSKDPAitHVAPWTWLYGNRrgdeVD
  180-  266 (138.35/63.90)	ARRSTDD......llvLAPFGQSARPlVLDSGKNL.LDGE.NWRTIVAEMLPTQGLELPRDTQWIPVElLDGTGNAWAWPA..HLCFTTSAPNNQ....VD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.01|      34|     372|     876|     910|       5
---------------------------------------------------------------------------
  876-  910 (62.84/42.21)	LPsPFLRLRR...GR.DAWEMLPACIPFWETLGLSP.AAG
 1247- 1285 (49.17/27.76)	LP.PYAGLEHaaiGSaENGVLTPASTPQGTTFTSSPdVAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.35|      18|      21|    1307|    1327|       7
---------------------------------------------------------------------------
 1307- 1327 (24.67/21.65)	SAADADAQLTDMTDetwGVLL
 1329- 1346 (30.68/16.70)	SKLSGTTQNSSMAH...GVLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.92|       9|      21|    1191|    1203|       9
---------------------------------------------------------------------------
 1191- 1203 (12.48/15.68)	SIMAarqvSWRIF
 1214- 1222 (20.44/11.69)	SVMH....CWRML
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19982 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ADADVFVPTEAPTTGQAPPTMTAEVTPLEADTAVSPSFTQR
2) AEIEDADFNFFDEPDDEFTEQPPMETRDVLEESNADTEMISAAQPTELALEGDASVLPDASNDADLLQYELADTTHASIAEKVDTEEDPIGARALSEPSIKPKRPLSPFGIREKLLPPPVPASHSQVHADAQSRHMGRRDSSFAS
3) AENGVLTPASTPQGTTFTSSPDVAGHGGNTPLTPAPSDTATSLPADSAADADAQ
4) EHLSAMVGIYPTPPDGFAPAQPGLLSAATPSVTQPDPSSSVLGTSPNDSMQPKPPAQHPPPPHDPSESNAAQDDLFGDVGEMGFG
5) EPALVAKDAARAKPPSDSVCITLPPARTGPGVKQAVHDTDGCDDDSSDSEEESYESSSSEASDSNLPPSLPWETRKRKRQLDDDVATYTSNDHMSSYAEEDEVGNVSDAVARDT
310
439
1261
353
597
350
583
1314
437
710










Molecular Recognition Features






MoRF SequenceStartStop




1) AEIEDADFNFFDEPDDEFTEQPPM
2) LSPFGIREKLLP
439
544
462
555