<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19980

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDGSAAVDSASSSAPPRLAPSADSHPPALGPHDAAAADDDDRELPVVLQDLVPLSYLIDRVVSSAYSDLATLIETLPGTHDDHQTKKRRVVDHVLNTRRQLVKLLVLTRWSAEAHRVHKAINIVAFLAIQNLAVDHAVDRLNETHQMLARARVRNYDLDSAIATLSLSSSAAPASFSSLPASLTDPFQLEAAAPLSDAEALETLSELNRVLLARLVLRLEPLPPRLADPSTWSIHDGRVTFTQPGLWEADMTYGGGNTEEEQGEEGREWYLLAVRFLFKVKDARGAWSAVPLGPIKDHLLDLCNRELLRRPYFPAPLPPRPITSSSRADGGTTSDPLANGESSDTAAKLAMLPDPQAAPPAPGEVPLLYPNGDAAAGEAKSKSEAEVWDEREREWKEERDRVKSKRKRDRPLERGYTFLQRLALSYQIEAIHSNAARLAATSWSGSLEVERRSFSAATSSVSAQNKSSEGADIEGEDEVRVHYWRPPPATQPQSGPGKPLRPGPSPHPSSSNVGGGAKIAPGRRSGPGGTIVFSLRPVTTTVSTPATIPSAESSLASPGKPAPSRRREAARTAALQAALDAATDPVSAESSDLPPRPSPTPPVPSSLSVAWLPSLASTPTAAPSALSSIDLTSMLGSDLDVERILRFVTAVHARETVERLANVVVGASDATRKAKLVVSPRSKSIVSDEQEEEETRVPYLHLPLVGAHAIGAYVDAVTGRFELRAVAARPSREGSAAAASRAGEDDATAAADEGSPTTSRDQRLRLASERIDRERFMPTQGASGSQGAPGPQQKGPSQGGAGQVDPDGWMKGVVEVVARIRASTILDELDTLLSLLSLPLASAPVRRLPLPPRELAKLGPNSSASAGRAAFLFVPLLADEPALAGWFLVFELFEDGIRAALMSTAERSDQLGHWSEVLEVGWLGAGAQPEAVAEGRGEASGKGANLGYEVKSETIRTLWWLCVRRASAFAIEQQLHLRRISYRREPVSGATASRLVIPSSALLRVPDLAQLLRPEAELRCAVEEDGRKRSPSEQSILLVYLRLAAGQPSPLPPPGGLPPSILYNPAKGALVLLTEGALGETVERLLRALATVVKIVRAAKPIGSPVKTPALAMHREIKLEKR
Length1122
PositionTail
OrganismRhodotorula taiwanensis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Microbotryomycetes> Sporidiobolales> Sporidiobolaceae> Rhodotorula.
Aromaticity0.05
Grand average of hydropathy-0.276
Instability index54.04
Isoelectric point6.21
Molecular weight119911.04
Publications
PubMed=29375494

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP19980
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     934.70|     241|     261|     575|     835|       1
---------------------------------------------------------------------------
  316-  525 (233.63/89.93)	...............PLPPRPitsssradggttsDPLANGESSDTA...AKL..AMLPD.PQAAPPAPGEVPL...LYPNGD.........A..A..............AGEAKSKSEAeVWDERER.....EWKEERDRVKSKRkrdRPL.....ERGY..TFLQRLALsyqiEAIhsnAARlaatswsgslevERRSF.SAATSSV.SAQNKS....SEGADIEGED.EVRV.....HYWRPPPATQP.........QSGPGkPLRPGPSPhpsssnvGGGAK...IAP..........G....................RRS
  577-  823 (387.41/167.36)	AALDAATDPVsaESSDLPPRP.............SPTPPVPSSLSV...AWL..PSLASTPTAAPSALSSIDLTSMLGSDLDVERILrfVTAVHARETVERLANVV.VGASDATRKAKL.VVSPRSKSIVSDEQEEEETRVPYLH...LPLVGAHAIGAYvdAVTGRFEL....RAV...AAR............PSREG.SAAAASR.AGEDDATAAADEGSPTTSRDQRLRLASERIDRERFMPTQGA......SGSQGAPG.PQQKGPSQ.......GGAGQ...VDP.........DGWMKGVVE........VVARIRAS
  836- 1098 (313.66/134.83)	LSLPLASAPV..RRLPLPPRE............lAKLGP.NSSASAgraAFLfvPLLADEP.....ALAGWFLVFELFED.GIRAAL..MSTAERSDQLGHWSEVLeVGWLGAGAQPEA.VAEGRGEASGKGANLGYEVKSETIR..tLWWLCVRRASAF..AIEQQLHL....RRI...SYR..............REPvSGATASRlVIPSSALLRVPDLAQLLRPEAELRCAVEEDGRKR.SPSEQSillvylRLAAGQPS.PL...PPP.......GGLPPsilYNPakgalvlltEGALGETVErllralatVVKIVRA.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.90|      18|      28|     172|     197|       2
---------------------------------------------------------------------------
  173-  193 (26.07/12.46)	PASFSSLPASLTDPfqlEAAA
  545-  562 (30.83/ 7.51)	PATIPSAESSLASP...GKPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.15|      25|     260|      19|      44|       3
---------------------------------------------------------------------------
   19-   44 (42.73/27.22)	APSADSHPPaLGPHDAAAADDDDREL
  283-  307 (47.42/26.33)	ARGAWSAVP.LGPIKDHLLDLCNREL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19980 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EAKSKSEAEVWDEREREWKEERDRVKSKRKRDRPLER
2) MDGSAAVDSASSSAPPRLAPSADSHPPALGPHDAAAA
3) PPRPITSSSRADGGTTSDPLANGESSDTAAKLAMLPDPQAAPPAPGEVPLLYPNGDAAA
4) REGSAAAASRAGEDDATAAADEGSPTTSRDQRLRLASERIDRERFMPTQGASGSQGAPGPQQKGPSQGGAGQVDP
5) VERRSFSAATSSVSAQNKSSEGADIEGEDEVRVHYWRPPPATQPQSGPGKPLRPGPSPHPSSSNVGGGAKIAPGRRSGPGGTIVFSLRPVTTTVSTPATIPSAESSLASPGKPAPSRRREAARTAALQAALDAATDPVSAESSDLPPRPSPTPPVPSSLSVA
378
1
318
732
449
414
37
376
806
610










Molecular Recognition Features






MoRF SequenceStartStop




1) ARTAALQAAL
2) EVRVHY
570
478
579
483