<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19976

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMAGPPLPMRPGPSGIGFGPNSSSGSTSRPPQPYPDALRSGVATMAAGRIASPLSLPNRPQSVSGQAQAAPGYATPPAQRPFTPTPLSNHRLDPSSSTATSPHGSASHRTTPTQYGYATGTTSPRGIKGTGPPPPVASTSQTPGLAVPDNSHPDASPWAAIPPRLKPEQAVPTTQLIELGEGWTVRYRAWKAPAIFVSCTPPSDVDGRPSGDASSTRGRMDYDPWRAPLGSVSPFPAGTTAASATAKGKAPAKAEPGSGSDGQPPAKKARKASTTASTDAAGPSTSRPGNAFDELLAQEMGASTSSTGSTSHALGLSISDTGSLLGEVIRTPPIPSSSAADPAAKPMRLPAAVRKARAEAAAVASASSSGAANTTSQPTHPLQASTASTDTSSDQPAASGSRLRLDTLSDPDFLSTDPLQLALRYLDRRRVELASEGRDRLDLLWHVQRQPVAMGGRQDGPDSKSEAGEDDSDDSSHPPGDGDGRVLWVFSVVKGGEKDAEEEHADESTFLLDGMTFDGLTALSQGDFTHATLFPRLYAARSGASAQFLSPAKSTARSYPSALALSEKILTVPSAVDPTPSTSPLQGAYTVFRDAVASCILDELAMNPPDGRKCLRFHRAATFFADPSRLLADLIPPPTFRIEVKPPSVQRSALFVSTIVTEVALTPLPTRPPMGKTTLGPLAAGCRLLLAPSEIPAIYVKDVLDGDFSAAHLHDLRAEWADARRLAGLSNDGPEVDAYVVCRLQAKDGQTGIEVFWPRCLALESRCLFETGVSTAAVAPAGSDLDSTASTSPAMARLVDHDGVAQHVPPGLPESNDVWAWYKDETQRREDEKAEALRREQDERESAQRKEQGDATASDKPKHASSAPHPAAPINERTPMSLGTASTEAPSPAELLALPPGQGGAPPAELPLARPEESRNDRDPHQAMDIDFGLGFYPSPAEPAHQMLPGSSAPPSAPMSSIDAALSSFDWGDGTFGASSSAGPAALPDPSLPVHDHRYEDSMLLGLTDDDFSFFDATPVTGGLPGMAGSLAPGAVPTSALAVSEPHAFAPFVSTTVQHPATNTFDFDMLGIGSHQAVPFPMPHDETFIDSTLHVTSPASRALAVSHSAPSQPIDARAFGVPSPASTGSVTQSPPVIDYSPAICDAPPHSDPSVQFAYITFDEPITAIDDRYDRRHGKYGLPSPQSEDGSTGLHLVPAHGREKRRTRSWYEALCDPHVLRADQLSAKRSSQSKGGRMQRDAPTRGTSHARSWVQRRGAHSADARRSVDSEAGVSPDGWPMDEAEDSSDVDEADDGQVPPSDDSEADERASVSVRKTAIPSADDSEYTAHAAILAVCGEALSRIVTVASKQDLDHHAATGPRSTTYEMIYATFAEVIVYQRFLRRALLSSAVQRKPDPASSASSTSLGETKLLVASVSLGLGVSPLFADPTVLPSLVQESTPVLSLRAQDCILRAEPRAFNYWRAMGFEPLTARKNVAAFMLAEADEQHNAPVWARDWLTSMSSTYEGLRLGQHQSARMPASTHSAGIEDGLLLVPPGRLAGHGTDFELKSIFAAIFELAKTHQNIVVYVHASVADSVDQLGPLADLLQQLAKCRAASTGPSVNVLAVPVAVSSLEASRGPDPSTFASLAFSVFDQLQIAIERLRLPAPETFPTARPPPIAPLGPAVRLFQAPAMTLALPTERQTRFALSWPPSSFDVEDRHRFLHVCYAARPVEGAPGHEWLVISVVDEKGETWRVLPRYLRYPPAVTVDVHRARIIWNFTKAIVDSADVEWRILVCKLGEPGAVEIKAWESVLNEFAAQSKRPLHLSYASIDSSPPLALARAGEAQTRPSTTSSSIPEEGEYTLQPSVTGAPKGTDSSVFDSDPSFFSFTPSEPISLPSTSVVAPASTFLIHVPRLTNLEHAASTSFDELKRLQTTSAYGIHLLCSTASKSSLYDDNVEAYLADVRRNFVELAGLGKARWGTSGRMAWHIEAARDSLLLSTV
Length1982
PositionKinase
OrganismRhodotorula taiwanensis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Microbotryomycetes> Sporidiobolales> Sporidiobolaceae> Rhodotorula.
Aromaticity0.06
Grand average of hydropathy-0.323
Instability index52.84
Isoelectric point5.45
Molecular weight210010.81
Publications
PubMed=29375494

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19976
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     331.26|      41|      42|      34|      74|       1
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   36-   76 (60.21/19.60)	ALR..SGVAT.MAAGRIASPLS...............LPNRPQSVSGQAQA.....AP...GYATPP
   77-  118 (41.67/10.83)	AQR..PFTPTpLSNHRLDPSSS...............TATSPHG.SASHRT.....TPtqyGYAT..
  218-  250 (33.40/ 6.93)	..R..MDYDP.WRA.....PLG..............sVSPFPAGTTAASAT.....AK...GKA.P.
  296-  350 (45.67/12.72)	AQE..MGAST.SSTGSTSHALGlsisdtgsllgevirTPPIPSSSAADPAA.....KP....MRLPA
  846-  883 (32.63/ 6.57)	AQRkeQGDAT.AS........................DKPKHASSAPHPAApinerTP....MSLGT
  884-  915 (38.66/ 9.42)	AST..EAPSP.AELLALPPGQG...............GA.........PPA.....EL...PLARPE
  916-  953 (45.38/12.59)	ESR..NDRDP.HQAMDI..DFG...............LGFYPSPAEPAHQM.....LP...GSSAP.
 1018- 1050 (33.65/ 7.05)	PVT..GGLPG.MA.GSLA.PGA...............VPTSALAVSEPHAF.....AP.........
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     146.54|      36|      42|    1231|    1266|       2
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  449-  484 (49.34/22.33)	QPV.AMGG......R..QDGPD.SKSEAgeddsdDSSHPPGD...GDGR
 1231- 1263 (52.76/24.47)	....SKGG......RMQRDAPTRGTSHA......RSWVQRRGAHSADAR
 1264- 1307 (44.44/19.28)	RSVdSEAGvspdgwPMDEAEDSSDVDEA.....dDGQVPPSDDSEADER
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      98.63|      26|      42|    1099|    1124|       3
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  366-  389 (36.04/11.18)	S..............SSGA..ANTTSQPTHPLQAST..ASTD
 1099- 1123 (35.11/10.68)	...............SRAL..AVSHSAPSQPIDARAFGVPSP
 1124- 1165 (27.47/ 6.60)	AstgsvtqsppvidySPAIcdAPPHSDPSVQFAYITFDEPIT
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.03|      19|      42|    1419|    1437|       4
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 1419- 1437 (32.37/18.55)	LGVSPLFADPTVLPSLVQE
 1464- 1482 (32.66/18.79)	MGFEPLTARKNVAAFMLAE
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.81|      31|      35|    1718|    1748|       5
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 1718- 1748 (57.81/32.10)	HE....W.LVISVVDEKGETWRVLPRYLRYPPAVTV
 1751- 1786 (47.01/24.79)	HRariiWnFTKAIVDSADVEWRILVCKLGEPGAVEI
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.03|      32|      42|    1318|    1350|       6
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 1318- 1350 (49.83/35.79)	PSADDSE..YTAHAAILaVCGEALSRIV...TVASKQD
 1359- 1395 (43.20/25.91)	PRSTTYEmiYATFAEVI.VYQRFLRRALlssAVQRKPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     114.55|      31|      34|    1617|    1650|       7
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 1570- 1602 (28.15/10.90)	........ASV..ADSV.DQLgpladllqQLAKCRAASTG...........PSVN
 1617- 1650 (48.50/37.84)	RGPdPstFASL..AFSVFDQL........QIAIERLRLPA...........PETF
 1654- 1694 (37.90/19.07)	RPP.P..IAPLgpAVRLF...........QAPAMTLALPTerqtrfalswpPSSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.57|      14|      14|     532|     545|       8
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  532-  545 (25.22/14.38)	LFPRLYAARSGASA
  548-  561 (25.35/14.50)	LSPAKSTARSYPSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.93|      11|      35|     396|     407|       9
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  396-  407 (15.06/11.01)	AASGsRLRLDTL
  433-  443 (19.87/ 9.91)	ASEG.RDRLDLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     196.08|      46|     501|     164|     209|      10
---------------------------------------------------------------------------
  164-  209 (83.82/48.56)	LKPEQAV.....PTTQLIELGEGWTVRYRAWKAPAIFVSCTPPSDV.DGRPS
  614-  658 (49.55/24.90)	LRFHRAAtffadPSRLLADLIPPPTFRIEV.KPPSVQRSALFVSTI......
  667-  708 (62.72/33.99)	LPTRPPM.....GKTTLGPLAAGCRLLLAPSEIPAIYV.....KDVlDGDFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.78|      30|     368|     805|     836|      12
---------------------------------------------------------------------------
  805-  836 (53.61/33.64)	QHVPPGL..PESND.......VWAWYKDetQRREDEKAEAL
 1174- 1212 (46.17/23.24)	RHGKYGLpsPQSEDgstglhlVPAHGRE..KRRTRSWYEAL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.26|      35|      46|    1812|    1853|      17
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 1812- 1848 (54.04/22.95)	DSSPPLALARAGEAQTRPSTtsSSIPEEGEYTLQ.PSV
 1861- 1896 (56.22/24.75)	DSDPSFFSFTPSEPISLPST..SVVAPASTFLIHvPRL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19976 with Med13 domain of Kingdom Fungi
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