<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19972

Description Mediator of RNA polymerase II transcription subunit 4
SequenceMAVPHPPTATDIEPLTPDEIARIPSAALPISLQISHLLSEFTRLSVQLFAIISTTSPSLVAGARGSAPTDAVYDALAQIDEKLASLLGMYDAHQQRQRRIEALIGELSRLDSNWRSSALRLEACVAELDPILASGKLDRIAIDRAKEAKMTPDGLLAYARLIAPFTSAPPASLFPPEIKLKGVGATDPTGRTLPPGAIPPFPTEATMRKGRLQFGREGLLQGYLGETEQVGAGRRDSATGALLPPDPTTTAGKPADTAARLEHEAKAHAAASALTTGAVLDGAEPEAEDFVFDLDLNPDM
Length300
PositionMiddle
OrganismRhodotorula taiwanensis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Microbotryomycetes> Sporidiobolales> Sporidiobolaceae> Rhodotorula.
Aromaticity0.04
Grand average of hydropathy-0.113
Instability index42.28
Isoelectric point4.98
Molecular weight31691.66
Publications
PubMed=29375494

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364141
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP19972
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.95|      16|      16|      73|      88|       1
---------------------------------------------------------------------------
   73-   88 (26.21/17.84)	YDALAQIDEKLASLLG
   90-  105 (28.73/20.18)	YDAHQQRQRRIEALIG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.73|      17|      17|     239|     255|       2
---------------------------------------------------------------------------
  239-  255 (30.14/16.10)	TGALLPPDPTTTAGKPA
  257-  273 (26.60/13.37)	TAARLEHEAKAHAAASA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.85|      17|      17|     175|     191|       3
---------------------------------------------------------------------------
  175-  191 (31.22/16.26)	PP.EIKLKGVGATDPTGR
  194-  211 (26.62/12.90)	PPgAIPPFPTEATMRKGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.77|      14|      21|     126|     141|       4
---------------------------------------------------------------------------
  126-  141 (18.97/17.75)	AELDP..ILASGKLdrIA
  148-  163 (19.80/10.72)	AKMTPdgLLAYARL..IA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19972 with Med4 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GETEQVGAGRRDSATGALLPPDPTTTAGKPADTAARLEHEAKAHAAASALTTGAVLDG
2) VGATDPTGRTLPPGAIPPFPTEATMRKGRL
225
183
282
212










Molecular Recognition Features






MoRF SequenceStartStop




1) DFVFDLDLNP
2) LLAYARLIA
289
155
298
163