Description | Mediator of RNA polymerase II transcription subunit 21 |
Sequence | MGDRLTQLQDAVDQLAQQFVACLHFVHRRHDLETLGPSDKIRDVKQEPQQKEVDPLPADEFQAGLKELSRDLIVKEQQIEYLISSLPGLDNSEKDQERNIKDLEEDLKAAEAQRQEALKERDQILSELDAVIRSIRRP |
Length | 138 |
Position | Middle |
Organism | Tolypocladium paradoxum |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Tolypocladium. |
Aromaticity | 0.03 |
Grand average of hydropathy | -0.823 |
Instability index | 61.88 |
Isoelectric point | 4.78 |
Molecular weight | 15922.66 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 ARBA:ARBA00003669 ECO:0000256 RuleBase:RU366036 |
GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule |
GO - Biological Function | |
GO - Biological Process |
Binary Interactions |
Repeats | >MDP19964 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 44.55| 14| 32| 65| 78| 2 --------------------------------------------------------------------------- 65- 78 (22.43/10.41) LKELSRDLIVKEQQ 100- 113 (22.11/10.19) IKDLEEDLKAAEAQ --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) EALKERDQI 2) SDKIRDVKQEPQQKEVDPLPADEFQAGLKELSRDLIVKEQQIEYLISSLPGLDNSEKDQERNIKDLEEDLKAAEAQ | 116 38 | 124 113 |
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