<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19963

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMTSRPPMGVPPRQPQRGLGSTLAVQRPAHHQRSLSQQYLSTSTSPIRKDSHPDSTNEPADAAQGRHHVSTPRRGGSKLRLELSNDLSTGPASATESPQSLTPSRIMPMSDAMDMDSLSPALSRASQQESDNVPMPLPRRRPQPSQLSVGTPRTSTPAPVQVKKDSRPKPYTVSVPAAAPRFVSTNRHEASNRDLFSKGLFSGHADFFPWSGRHHEDEWSPEAAQKGTWDRGSQNEAASARLAIFPALKQKSGLNALSTIFMGVLNQRRHRGQITTPSTFKPPPRVTLTDTKREVWLKDLANPAISLRRLSRTIPHGIRGRTLLDQCLNKNVPTERAVWLAKCVGANEIRAFKRKGAGGAFVMGGESKWVRDWTVFVEQFVEAVVSAFGETDWKARVTYAIRLATNLYSEQLLDRDHYLDWIMCGLESSSQSRIPMWILIAQITWADLLRSRKYGRRLAYALLGHLHTIYNDPDRDILIQLSSQLAGLLKTLVQRNPESFISPSLWPKYRDTLRASLPVDDGVSQGAYHKVNARNALLLVANTTSAPAGRQDLVKLLDSAVQGQNDRDLAAKCWATLDDKPEIVKIVVEWATSLHRPGLAKIYVAARLITSWSTFNINATQPILDILSDIRPGDKRRSKCVFHLVAELVRSRLFSVPQYMQWLIGRGGLHDAADIDPDAGPCASRLLIELPVHCLPESQKAQRSNLLRRAGHYSTTDEANDIANALRCVDDTLGLSPHFANADPQAKCFPLRCFPLRKLLRRVSNSSKAVQTAIGAHLGDVFTTELLGKVDSVIALSIFNSVRAMLETVQDFFVLSHILEVCSTASDVEVLASCVDTINSHLEVFLALGCADSLFGVLIDRLRAVNSDQGVVARPLLAALSSLARRLPHQEEIAKQLVRELAQSDRSNAIDACSPVSDNMAMQTQGAEGEVSEQIDKLLASGNTIDHPTMNRLFRNIIPKLEAGWTKRDESRRVFASLLTRLRIFDTQHFDKLMADWVSHIRTLKDRPSLLELFPLLASPGCLSISTMLHTANAGTPAMEEVPLDPGVTPSGSAVYLQELLQLLITALPKSTSLDSDEIYRFEIQQKSARSEQPKALLLLIRNALVEYSALRNRAPGRKFLLDDAACEGRLLETLKYLVVADSTAVAHVLNIGNLPVGATALVHKIITKLLIPDDDGGVETSFDQILGLANELTMPFCQLKLNLDLSAPQRSSGETDDDNPSRFEAFAKAMDRAIEARNILWTGMLPCLSQDITRNLSSQAHTRFLDLMPSLKSTSFEDDAVSEHRVHLAENLLGVLEAINSGQLPSKSAQLTANLVEKLSDLWEIVASKDEERVRARKEVLGHWLPMLLRFITLNSISPEPLQTPNPNQPNAARILIPPNYEARARIILVLCGLLLELDSQPQTSRGSLSQEVFDIAVLLVDALPDDLRVQCARVILFMPGGTASTGTTSDPRLYYLFSVPQPTLAENLKLAHRDKGSIPYSAAARGMGAMYGIGPASQERLAPFMLRRWEILSEPTPNVGENDTSLSLGLFEAIKIQ
Length1538
PositionKinase
OrganismTolypocladium paradoxum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Tolypocladium.
Aromaticity0.06
Grand average of hydropathy-0.215
Instability index47.09
Isoelectric point8.49
Molecular weight169683.06
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19963
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     298.46|      66|     147|       2|      67|       1
---------------------------------------------------------------------------
    2-   67 (117.38/51.03)	TSRP.PMGVPPR.QPQRGLGSTLAVQRPAHHQRSLSQQYLSTSTSPIRK....DSHPDSTNEPADAAQGRHH
   94-  152 (91.65/38.44)	TESP.QSLTPSRiMPMSD.AMDMDSLSPA.LSRA.SQQESDNVPMPL.........PRRRPQPSQLSVGTPR
  153-  214 (89.43/37.35)	TSTPaPVQV..K.KDSRPKPYTVSV..PAAAPRFVSTNRHEASNRDLFSkglfSGHADFF..P...WSGRHH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     216.79|      54|      59|    1203|    1256|       2
---------------------------------------------------------------------------
 1046- 1082 (31.11/15.15)	.............GVTPSGSAVYLQEL......................................LQlLITalP..KSTSLDSDEIYRFE.......
 1203- 1230 (34.54/17.80)	.................................................................LD.LSA..PQRSSGETDDDNPSRFEA.FAKAM
 1231- 1292 (76.09/49.91)	DRAIEARNIL.WTGMLPCLSQDITRNL..............................ssqahtrfLD.L.M..PSLKSTSFEDDAVSEHRVhLAENL
 1293- 1376 (52.98/32.05)	LGVLEAIN....SGQLPSKSAQLTANLveklsdlweivaskdeervrarkevlghwlpmllrfitLN.SIS..PE....PLQTPNPNQPNA..ARIL
 1380- 1407 (22.07/ 8.17)	NYEARARIILvLCGLL...............................................leLD..SQ..PQTSRG..................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     176.22|      35|     149|     544|     578|       3
---------------------------------------------------------------------------
  444-  480 (48.12/30.46)	WADLLR.................................SRK.YGRRLAYALLGhlHTIYNDPDRDILIQL
  482-  504 (25.06/11.58)	.......................................SQL.AG......LLK..TLVQRNPESFISPSL
  505-  572 (39.23/23.18)	WPKYRDtlraslpvddgvsqgayhkvnarnalllvanttSAP.AGRQDLVKLLD..SAVQGQNDRDLAAKC
  573-  610 (25.66/12.07)	WATLDD......................kpeivkivvewATS.LHRPGLAKIYV..AA......RLITS..
  611-  639 (38.15/22.29)	WSTFN.....................................iNATQPILDILS..DIRPGDKRR...SKC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.41|      26|     150|     768|     794|       4
---------------------------------------------------------------------------
  768-  794 (38.59/29.79)	AVQTAIGAHLgDVFTTELLGKVDSVIA
  837-  855 (27.22/14.80)	.....INSHL.EVFLA..LGCADSLFG
  863-  881 (23.60/11.78)	AVNSDQG.....VVARPLLAALSS...
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19963 with Med12 domain of Kingdom Fungi
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