<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19954
Description |
Mediator of RNA polymerase II transcription subunit 5 |
Sequence | MDGNTRDPRGALRESTEYWSNFVARCISRRLDTDRFEEFVPLVYSQHPLAPIFIADLFLKPQPTNNVSLDPRMPLYIKVLSRLGYIDAPSILWTMCKYSSLHAQLRLSQNGDNKEDQTRCWRISSWAEEVMFYHVIKTVVEGSAFRDSRAALVLVKSICKWMNLFTSASTAFAADVLGEIQSSQVRDEMDVSRAAFIPLLLRLVETPSLVKVISKPAAKAVRKELSESLSGFLHTLQPSPGFVERLEIFRSETLARLDPLDNKNQAATSAAIDDLLENTVGLDNFVVPDIPISTTRAGLYVHLNASLVGRPLIDDNALLSYLHNRYQGQTQSSAIDLILASFDILANTVFRNEGQKDAHLLRSFLINKVPLLLCQLCSPQFSTTSSEFCITEALNQVDTSVFPTASLMFDESRSNNPYTESVREEFCTACALHGLVQREHVERILGETSMSYEPSLERYSKDKLVQDCLSDPEKIQGMVRELDKMDGNVGAVSQALVELMRQLCNNKETMSLKLLCGQLAQKPQSLDILLLFEKLPAILEPLCQLLDNWRYDDDQGEYQPIYEEFGAILLLVLAFAYRYNLTAADIGITSTDSCITKILNRAHMSRDMDELTEQEKEHMNGWVHGLFDSETGGLGDDLMSSCPPQDFYLFVASLFQNIVVAYTYGYLNDETLKSGIEYLVDTFLLPSLGPAIRFLADYLWVEQKEQKSIIKILQLILLPSSISGEASTMLSSVKNLIAKPLEHSLRTYQKQDPKNQDIEPLLRALKDSLPLSRRTGGAEHNELESWGSSSSSGLAGAVKHTVQGLVQWSMHHGINVMPTSYTHRQVIAACRIAGTSRVLRVMLEEIRHQSEAGSANIVYDVVAALICAPDVTNEPPGAGNLMDAAGNVAPTLQRRLKLREVLRLDAQDCRKLQKRDPALADIIVRLHRRVESHMVLPQPQAMLEASDMPLDLSGGAAGLGDAMAAAAGVQGDGISVDGVGLDMGLGGVSSDLGLGGPSGSVAGLDSTSDGELFGAIDTSMDMFNGWDGMDLGGN |
Length | 1034 |
Position | Tail |
Organism | Tolypocladium paradoxum |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes>
Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Tolypocladium.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.106 |
Instability index | 43.19 |
Isoelectric point | 5.04 |
Molecular weight | 114125.86 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364142
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP19954
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 107.17| 33| 37| 958| 993| 1
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958- 991 (54.19/35.17) GLGDAMAAAAGVQ..GDG...ISVDgVGLDMGLGGVSSD
993- 1030 (52.98/35.71) GLGGPSGSVAGLDstSDGelfGAID.TSMDMFNGWDGMD
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 33.85| 11| 19| 510| 527| 2
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510- 527 (13.48/21.63) MSLKLLCgqlaqkpQSLD
537- 547 (20.37/10.28) AILEPLC.......QLLD
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 29.68| 10| 19| 338| 349| 3
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338- 349 (12.29/12.74) ILASFdiLANTV
360- 369 (17.39/ 9.55) LLRSF..LINKV
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 57.93| 16| 19| 373| 388| 4
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373- 388 (30.80/20.77) LCQLCSPQFSTTSSEF
394- 409 (27.13/17.39) LNQVDTSVFPTASLMF
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 130.11| 31| 32| 664| 695| 5
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632- 661 (37.58/22.49) .GGLGDDLMSSCPPQ..DFYLfVAS..LFQNIVVA
664- 695 (49.30/36.68) YGYLNDETLKSGIEYLvDTFL.LPS..LGPAIRFL
698- 730 (43.24/27.04) YLWVEQKEQKSIIKIL.QLIL.LPSsiSGEASTML
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 49.95| 15| 19| 772| 786| 6
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772- 786 (27.70/16.93) SRRTGGAEH..NELESW
792- 808 (22.26/12.27) SGLAGAVKHtvQGLVQW
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 75.39| 24| 139| 456| 482| 7
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456- 482 (39.06/34.96) LER..YSKDklvQDCLSDPEK..IQGMVREL
599- 626 (36.33/24.03) LNRahMSRD...MDELTEQEKehMNGWVHGL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 53.78| 16| 38| 185| 200| 8
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185- 200 (27.28/17.73) VRDEMDVSRAAFIPLL
221- 236 (26.50/17.00) VRKELSESLSGFLHTL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 70.09| 21| 138| 2| 22| 9
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2- 22 (40.80/24.02) DGNT.RDPRGA..LRESTEYWSNF
141- 164 (29.29/15.44) EGSAfRDSRAAlvLVKSICKWMNL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 39.72| 12| 19| 291| 302| 10
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291- 302 (22.19/15.27) PISTTRAGL.YVH
311- 323 (17.54/10.45) PLIDDNALLsYLH
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 48.54| 13| 162| 746| 758| 11
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746- 758 (25.66/16.70) RTYQKQDPKNQDI
910- 922 (22.88/14.10) RKLQKRDPALADI
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