<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19950

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMEPTGQNGTRTDHDRDPAVNGVNGMSVGGGQGSAPDKGKAPAASNDNATVNGGEVGGTALERSRRPPPQAGGPSTEAHSRMNDLPDEIRHITEGFIPLSLLLTRLAQVTHNSLQEKVAELAKMPLPTAAANGTPSYTSGGPDDSSSDNLRKKGSLTSFAQDMHGKWLKALVITEWSRKSDMVSKLIDLKFHIDQQRILYDACLDNMVNVKRDLAFARMPSPDLKTALQVLSTGTAPWMPDLSYIDPPPLTPDEQLKWMNDLNTLLSLRLNLDDYDKIPYHFRNYEIGSGRVTFKVDGEFEVDLTIADEDFEKQFWFIDFRYAFAPAAASLSDALRTYLEGCVNEALSKDGLAGCYQFLHEFVLTCKINELKRQALQLSRSSWTGTLMVEPLNRALAIQYWTSRTAITGTKSWILLAVNSGRRPNGKTDPKSSSFLVAKWYRDNQEMTDVNVELDVKNLSTEALLRDVVARHIAIILTSIHDKLLTAARFQNREASMILDVAKSDPAASRLVMQVGYRSQATLLVEPMTGAFALKPHSRFTIQYEHQLNNGKNAAEDGVACLENVRCALLDDEINRRGSCMGWLARKSPLMLEEMRSVTKLREWTRAVWLQKDGWGANWLVVVFLGLGGDEWWLLEASVPLSATPSPGINECLRNRDETNRAVKFKAQLPLNKGYPDQSEAFWTNLALFATGIITQSVDMRELHRHRIKSKSSDNVDVSLPQQVRLPSTEISLSALFPAMVSCRSGDGADGGSSEGDHMAENAELFSPMQKYTGTALTPKQAWADDVVTINFKGIQSRSKSADEKREDGTRAYELICVSDAIIKVRRPANFEALKNTVDRDVSYNPHRGEFSLRIRRRVGKPILDDLKSRIKAIDRFVNFFEALENVNGTITSEYATLKQVTFCYCEKHGQKGDNGLGETQTPKRWCVVLDLSKDDIDIEIEAGNPHLRVVDLMQRLVNSDGGIGALMAWLPASLPALRAIDEMESRWASLQAEKRGRLVFSMKTIAWMSIGYDITATKKHVALEVRLRRRRGQAWWHVYRSDAGANAAPEDEFGKALKPIWAAKGEDWLGLMTGAAGEPSSGVVGMLLAVDDAIRGAV
Length1098
PositionTail
OrganismTolypocladium paradoxum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Tolypocladium.
Aromaticity0.07
Grand average of hydropathy-0.358
Instability index40.21
Isoelectric point6.42
Molecular weight121782.95
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP19950
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     251.17|      80|     613|     134|     215|       1
---------------------------------------------------------------------------
  134-  215 (134.08/104.21)	P...SYTSG.GPDDSSS..DNLRKKGSLTSFAQDMHG.......KWLKALVITEWsRKSDMVSKLIDLKFHiDQQRILYDACL.DNMVNVKRDLAF
  737-  830 (117.09/81.82)	PamvSCRSGdGADGGSSegDHMAENAELFSPMQKYTGtaltpkqAWADDVVTINF.KGIQSRSKSADEKRE.DGTRAYELICVsDAIIKVRRPANF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     133.91|      43|     177|     224|     272|       3
---------------------------------------------------------------------------
  224-  272 (68.41/52.72)	KTALqvlsTGTAPWMpdLSYIDP...PPLTPDEQ......LKWMNDLNTLLSLRLNLD
  403-  454 (65.50/36.47)	RTAI....TGTKSWI..LLAVNSgrrPNGKTDPKsssflvAKWYRDNQEMTDVNVELD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.50|      20|      22|      12|      32|       4
---------------------------------------------------------------------------
   12-   32 (32.88/29.19)	DHDRDPAVNGVNGmSVGGGQ.G
   36-   56 (30.62/20.37)	DKGKAPAASNDNA.TVNGGEvG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.80|      24|     133|     372|     396|       5
---------------------------------------------------------------------------
  372-  396 (36.27/29.11)	RQALQLSRSSwTGTLMVEPLNRALA
  509-  532 (42.53/27.54)	RLVMQVGYRS.QATLLVEPMTGAFA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     206.69|      66|     386|     568|     653|       8
---------------------------------------------------------------------------
  580-  653 (111.11/91.01)	MGWLarksPLMLEEMRSVTKLREWTRAVWLQKDGW......GANWLVVVF...............lglgGDEWW.LLEASVPLSATPSPGINECLR
  967- 1058 (95.59/46.21)	MAWL....PASLPALRAIDEMESRWASLQAEKRGRlvfsmkTIAWMSIGYditatkkhvalevrlrrrrGQAWWhVYRSDAGANAAPEDEFGKALK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19950 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EKVAELAKMPLPTAAANGTPSYTSGGPDDSSSDNLRKKGS
2) MEPTGQNGTRTDHDRDPAVNGVNGMSVGGGQGSAPDKGKAPAASNDNATVNGGEVGGTALERSRRPPPQAGGPSTEAHSRMNDLPDEIR
115
1
154
89










Molecular Recognition Features






MoRF SequenceStartStop




NANANA