<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19949

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDTAEYDTNTLLINNIASIAFRVYESPSDLSQSFASVALEIENTLREGGHVVFYDAVRRGIWHFQIIGKEGHDDVTSHGIDTSLELCGQTLVVGEEGALEPASLQRTRPQQQQQQGIQTPTNSISSASALDHSQRNAFASASQGAAPSSQDQDAKAADASGVDSKAGATPNKTVYENFVTAVLLSMSSTFCNRSGAVPLNYRTVLLPPEPLESDGPHDADAEQCLVLATLGAYLTTTGALVISFGVSRCKGLTSFVDLAATSPALPGTPILAAPFGVVAHNQFSSAGEAGTASLAQTPNTQALSLRGGPDVHDSLWKQACLRILKLRGVASASLSDCSWVSLLVPKPRLQDVHNETKRAQALGSGISIPWPRPLCFRKRVVEVFSTSRVGDSILSGHEESHDPLGSARGWFNTATERDEKVSKRKAERAAASKDSRSAESRAPKPSAPSPVAIRRPSTAAASAIYPTPPDGIQHPNGVTPSFDGTLSSPGNPLSVAPATETDPVAPSTSAMGDTFDVEGDFNDSKRQRSESNLLVEAEHMFGDMGEDMFGDNDITEADFNFFDEQQPGDSDLDMSMDDAGVTNNAGDEAPKADEESLQAVNEAKPESVPERDTVVFAKPELKHARSSRNDTVGQRGRDAPSGAIKRESSPFDPHTVFKRVRASLAATERGSSKSAQDSIRMTRIFESMSFDATLPMINKKYEQGGHFDYKKIASTEKPRLEPGMLPETDYLKRHGRQGRRLRDRRLHAGALVRTLTGIEPPSSHPSPTKVEGSLSEDDDSSLGSDQDDSSYTTEEPTSPLKSSVKLVALDDDATSQVTSLREVEPLEEPNQHLAIELPRLSKPEVPELPLALLFSDPEPLSLDLSLSDDDLIQVAQILTEQAALGSLDICNTQEGTSPQPATNLSCQSLSVDARNAMRILRDFVPSLLRGAGTISLKGFLDIPDIPLLGQPSRLQPRPIPGRDPNAEPLRPSNLYQIPGPHLEVRRAELKLSVLPSAVPFWESLGLAPSSGGKDVNAICVFPGWNGMVDNVKTFLGRVKSVYEMLKLGSLESVPSSADMDDGILPYEVDRISTSPDATVTGHGSALIEIMETLRGAISNLTVTETNVVVYFVYSPHNPGTIVEACIAFQRFFDSYRKALASQRETAPNELVLQLVSADMLSSATSVVVTPAPELIKLCMETYDRCTLFGGPMPAPAIKLEQPLPRIIDFKLTMSPSASLIRENSCIHVAYAQSTDGRWITAAWTDDRGSQQETVSYCLGRKGRPQSRSMNEVAHEIWTSTLDLISVWKVHWRIVITKCGPMDQQEVDCWVDLARTEIKASVTMVLMTVDTNPSLQLIPPVVKLPQPSAPFYTTPVSTPQASIVSPEQSGTPATPARDANATAVTPGADGAGETDSDAVLSDITDQTWGAVVGHRLNNSLSVLEVHPALVSGYLIKRTGTRTEDAPVLMEVNLVHTDASPRAYEPLLREMLSYFRGLGTLARARGVVQRETDVRPWHVAAAEKAVRAMYLLM
Length1511
PositionKinase
OrganismTolypocladium paradoxum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Tolypocladium.
Aromaticity0.05
Grand average of hydropathy-0.311
Instability index47.83
Isoelectric point5.07
Molecular weight163024.12
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19949
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     277.98|      90|     119|     574|     672|       1
---------------------------------------------------------------------------
  574-  643 (79.28/49.81)	................................................M.SMDDA.GVTNNAGDEAPKADEESLQ..AVN...EAK..PESVPERD.TVVFAKPELKHarssrndtvGQRGRD..APSGA
  644-  750 (122.52/60.96)	IKRESSPFDPHTVFKRVR....ASLAATERGSSksaqdsirmtrifesM.SFDATlPMINKKYEQGGHFDYKKIA..STE...KPRlePGMLPETD....YLKRHGRQ.........GRRLRDrrLHAGA
  758-  858 (76.18/33.10)	IEPPSSHPSPTKVEGSLSedddSSLGSDQDDSSytteeptsplkssvkLvALDDD.ATSQVTSLREVEPLEEPNQhlAIElprLSK..PE.VPELPlALLFSDPE.........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.17|      37|     898|     443|     484|       2
---------------------------------------------------------------------------
  443-  484 (67.71/34.13)	PKPSAP...SPVairrpSTAAASAIYP....TPPDGIQHPN..GVTPSFDG
 1344- 1389 (56.46/21.14)	PQPSAPfytTPV.....STPQASIVSPeqsgTPATPARDANatAVTPGADG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.33|      10|      15|     959|     970|       3
---------------------------------------------------------------------------
  959-  970 (15.81/13.12)	IPGrdPNAEPLR
  977-  986 (20.52/ 9.68)	IPG..PHLEVRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.52|      28|      29|     244|     271|       4
---------------------------------------------------------------------------
  244-  271 (48.54/33.92)	FGVSRCKGLTSFVDLAATSPA.LPGTPIL
  275-  303 (41.97/28.10)	FGVVAHNQFSSAGEAGTASLAqTPNTQAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.52|      21|      40|     511|     533|       5
---------------------------------------------------------------------------
  511-  533 (31.67/26.76)	M.........GDTfDV.EGDFN..DsKRQRSESNL
  540-  572 (24.84/11.87)	MfgdmgedmfGDN.DItEADFNffD.EQQPGDSDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.39|      38|      40|    1072|    1109|       6
---------------------------------------------------------------------------
 1072- 1109 (59.68/36.02)	STSPDATVTGHGSALIEIMETLRGAISNLTVTETNVVV
 1114- 1151 (64.71/39.66)	SPHNPGTIVEACIAFQRFFDSYRKALASQRETAPNELV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19949 with Med13 domain of Kingdom Fungi
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