<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19943

Description Mediator complex subunit 14
SequenceMAPVQLENHQLVPPGGGGGGSGGPPSAPLRLXXXXXXXAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQISFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAILRGFNANENSSIETALPALVVPILEPCGNSECLHIFVDLHSGMFQLMLYGLVKFQLIVFLMVFNHLFWLGQQRCKQSIKHLPTISSETLQLSNYSTHPIGNLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYKYYFMSVNAADREDSPAMALLLQQFKENIQDLVFRTKTGKQTRTNAKRKLSDDPCPVESKKTKRAGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQVEGDGFSHAIRLLKIPPCKGITEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP
Length1440
PositionTail
OrganismPan paniscus (Pygmy chimpanzee) (Bonobo)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Pan.
Aromaticity0.07
Grand average of hydropathy-0.157
Instability index52.02
Isoelectric point9.10
Molecular weight158632.72
Publications
PubMed=22722832

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP19943
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     337.62|      62|      64|     988|    1049|       1
---------------------------------------------------------------------------
  930-  981 (65.33/26.02)	.......FDNSKLVEGFYPA.PGLKTFLNMFVD..SNQD.ARRRSVNEDDNP..PSPIGGDMMD..S..
  988- 1049 (117.84/52.75)	PPPQQQPFPKQPGTSGAYPL.TSPPTSYHSTVN..QSPSMMHTQSPGNLHAA..SSPSGALRAP..SPA
 1055- 1116 (97.97/42.63)	PPPSSHGISIGPGASFASPHgTLDPSSPYTMV....SPSGRAGNWPGS.PQV..SGPSPAARMPgmSPA
 1145- 1192 (56.48/21.51)	PPPR.....KLPQRSWAASI...PTILTHSALNilLLPSPTPGLVPG.LAGSylCSP............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.03|      24|      28|    1312|    1337|       2
---------------------------------------------------------------------------
 1312- 1337 (43.68/30.77)	PdqATQLKWNVQFC..LTIPPSAPPIAP
 1341- 1366 (39.36/21.21)	P..AVVLKSKMLFFlqLTQKTSVPPQEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.19|      29|      30|      67|      95|       3
---------------------------------------------------------------------------
   67-   95 (46.39/36.30)	LTDLLPRKSDVERKIEIVQFASRTRQLFV
  100-  128 (48.79/38.61)	LVKWANNAGKVEKCAMISSFLDQQAILFV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.08|      24|      29|     250|     278|       4
---------------------------------------------------------------------------
  250-  273 (40.30/27.69)	ILVEDKETGDGRALVH....SMQISFIH
  280-  307 (36.78/15.10)	LFADEKPLQDMYNCLHsfclSLQLEVLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.64|      40|     123|     749|     797|       5
---------------------------------------------------------------------------
  711-  767 (51.87/37.40)	VFA....NCP..LNGTStreqgpSRHVYlTYENLLsepvggrkvVEMFLnDWNSIARLYECVL
  768-  821 (54.77/56.19)	EFArslpDIPahLNIFS......EVRVY.NYRKLI.lcygttkgSSISI.QWNSIHQKFHISL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.71|      31|     123|     213|     247|       6
---------------------------------------------------------------------------
  211-  241 (51.80/42.93)	ANLTVANGRVKFRVEGEFEA.TLTVMGDDPDV
  333-  364 (46.91/26.80)	LSLSVWNQQVLGRKTGTASVhKVTIKIDENDV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.77|      23|     123|     370|     400|       7
---------------------------------------------------------------------------
  386-  410 (31.07/18.23)	RAMKI.DHLSIEKLLIdsVH......ARAHQK
  419-  448 (27.69/15.85)	RGFNAnENSSIETALP..ALvvpilePCGNSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.60|      14|      39|    1233|    1247|       8
---------------------------------------------------------------------------
 1233- 1247 (21.47/18.89)	LKCRVALSP.KTNqTL
 1271- 1285 (22.14/13.34)	FETRVAGPPfKAN.TL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.33|      10|      29|    1388|    1397|       9
---------------------------------------------------------------------------
 1388- 1397 (17.56/10.82)	PRQQNSSVAA
 1414- 1423 (19.77/13.23)	PRQGECTIFA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.49|      14|      29|     166|     179|      10
---------------------------------------------------------------------------
  166-  179 (26.30/16.83)	RLPTCIRDKII....PPD
  192-  209 (19.19/ 9.79)	QLNQILRHRLVttdlPPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.55|      28|      34|     495|     526|      11
---------------------------------------------------------------------------
  495-  526 (41.94/37.70)	IKHLPT..ISSETLQLSNYSTHpignLSKNKLFI
  528-  557 (45.60/29.19)	LTRLPQyyIVVEMLEVPNKPTQ....LSYKYYFM
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19943 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWA
956
1156










Molecular Recognition Features






MoRF SequenceStartStop




1) MASAGVAAGRQAEDVLPPTSDQPLPDTKPLP
2) PRPQSPARAREEENYSFLPLVHNIIKCRDGAGLK
1
50
31
83