<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19942

Description Mediator complex subunit 14
SequenceMAPVQLENHQLVPPGGGGGGSGGPPSAPAPPPREPPWRRPLQLRLXXXXXXXAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQISFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAILRGFNANENSSIETALPALVVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTISSETLQLSNYSTHPIGNLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYKYYFMSVNAADREDSPAMALLLQQFKENIQDLVFRTKTGKQTRTNAKRKLSDDPCPVESKKTKRAGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQVEGDGFSHAIRLLKIPPCKGITEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP
Length1466
PositionTail
OrganismPan paniscus (Pygmy chimpanzee) (Bonobo)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Pan.
Aromaticity0.07
Grand average of hydropathy-0.205
Instability index53.08
Isoelectric point9.06
Molecular weight161695.01
Publications
PubMed=22722832

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coactivator activity	GO:0003713	IEA:Ensembl
GO - Biological Process
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP19942
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     215.65|      60|      64|    1014|    1075|       1
---------------------------------------------------------------------------
 1014- 1045 (49.94/13.98)	...........................................................PPPQQQPFPKQPGTSGAYP..L.TSPPTSYHSTVN
 1047- 1112 (92.32/35.30)	SPSMMHTQSPGNlHAASSPSGALRAP..SPA.......................sfvptPPPSSHGISIGPGASFASP..HgTLDPSSPYTMV.
 1113- 1195 (73.39/22.29)	SPSGRAGNWPGS.PQVSGPSPAARMPgmSPAnpslhspvpdashspragtssqtmptnmPPPRKLP...QRSWAASIPtiL.T......HSALN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.03|      24|      30|    1338|    1363|       2
---------------------------------------------------------------------------
 1338- 1363 (43.68/34.52)	PdqATQLKWNVQFC..LTIPPSAPPIAP
 1367- 1392 (39.36/23.80)	P..AVVLKSKMLFFlqLTQKTSVPPQEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.19|      29|      30|      81|     109|       3
---------------------------------------------------------------------------
   81-  109 (46.39/30.06)	LTDLLPRKSDVERKIEIVQFASRTRQLFV
  114-  142 (48.79/31.97)	LVKWANNAGKVEKCAMISSFLDQQAILFV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.08|      24|      29|     264|     292|       4
---------------------------------------------------------------------------
  264-  287 (40.30/32.57)	ILVEDKETGDGRALVH....SMQISFIH
  294-  321 (36.78/17.89)	LFADEKPLQDMYNCLHsfclSLQLEVLH
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.33|      10|      24|    1414|    1423|       5
---------------------------------------------------------------------------
 1414- 1423 (17.56/ 8.86)	PRQQNSSVAA
 1440- 1449 (19.77/10.88)	PRQGECTIFA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     510.78|     169|     396|     388|     604|       6
---------------------------------------------------------------------------
  388-  604 (250.86/324.34)	PPLPAsdsklveramkidHLSIekllIDSVHARAHQKL.............QELKAILRGFNAnensSIETALPalvvpilePCGNSEC....LHIFVDLHS...GMFQLMLYGLD.QATLDDMEKsvnddmkriIPWIQQLKFWLGQQRCKQSIKHLPTiSSETLQLSNYSTHPIGNLSKNK...........LFIKLTRLPQYYivvemlevPnKPTQLSYKYYFM.........SVNAADREDSP....AMALLLQQFK
  800- 1013 (259.92/215.80)	PDIPA.............HLNI....FSEVRVYNYRKLilcygttkgssisIQWNSIHQKFHI....SLGTVGP........NSGCSNChntiLHQLQEMFNktpNVVQLLQVLFDtQAPLNAINK.........LPTVPMLGLTQRTNTAYQCFSILPQ.SSTHIRLAFRNMYCIDIYCRSRgvvairdgaysLFDNSKLVEGFY........P.APGLKTFLNMFVdsnqdarrrSVNEDDNPPSPiggdMMDSLISQLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.60|      14|      36|    1259|    1273|       7
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 1259- 1273 (21.47/20.45)	LKCRVALSP.KTNqTL
 1297- 1311 (22.14/14.39)	FETRVAGPPfKAN.TL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.49|      14|      28|     180|     193|       8
---------------------------------------------------------------------------
  180-  193 (26.30/14.24)	RLPTCIRDKII....PPD
  206-  223 (19.19/ 8.26)	QLNQILRHRLVttdlPPQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19942 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWA
2) PVQLENHQLVPPGGGGGGSGGPPSAPAPPPREPPWRRPLQ
982
3
1182
42










Molecular Recognition Features






MoRF SequenceStartStop




1) MASAGVAAGRQAEDVLPPTSDQPLPDTKPLP
2) PRPQSPARAREEENYSFLPLVHNIIKCRDGAGLK
1
50
31
83