<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19933

Description Mediator complex subunit 12 like
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLSILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQAPDPNLEWTQISTRYLREQLAKISDFYHMASSTGDGPVPVPPEVEQAMKQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLSLLLSDSPNLLAAHSPHMMIGPNNSSIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNENKSTNPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSSSLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPVGENADEHYSKDHDVKMEEQSIMAHMGIDSGTTNIFDEVDKSDFKTDFGSEFPIFSPMPGESCENANTSLGRRMSVNCEKLVKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTETGVGDEGQKARKNKQETFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACFLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLKNDDFTMRGLRCDGNADDIWTASQNTKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNSSNSGMSLFNPNSIGSADTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRRVIKYEEQHHLLLYHTHPMPKPRSYYLQPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMHHPQSTLWGYNLVGQPQQPGFFLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
Length1984
PositionKinase
OrganismPan paniscus (Pygmy chimpanzee) (Bonobo)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Pan.
Aromaticity0.07
Grand average of hydropathy-0.390
Instability index54.11
Isoelectric point6.90
Molecular weight222502.14
Publications
PubMed=22722832

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19933
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     545.93|     137|     150|    1135|    1284|       1
---------------------------------------------------------------------------
  946- 1090 (153.16/100.05)	..VVKH.VVNPS.........E..CSS.PER..C.ILAYLYDLYVSCsHLRSKF.GDLF...SSACSKVKQTIYNN.........VMPAnsnlrwdpdFMM..DF.IENPSARSI.....NYSMLGKILSDNAanrysfvcntlmnvcmghqdagriNDIANFSSELTACCTVLSSEWLG.......VLKA
 1135- 1284 (210.83/172.76)	EDVVQH.VALPSLLaaaCGDAD..AEP.GARMTCRLLLHLFRAPQAC.FLPQAT.GKPFPgiRSSCDRHLLAAAHNSIEVGAVFAVLKA.........IMMLGDAkIGNNSVSSLKN..DDFTMRGLRCDGNA........................DDIWTASQNTKSCGKSISIETANlreyaryVLRT
 1289- 1425 (181.94/118.49)	EWVGEHcLKEPERL...CTDKEliLDPvLSNMQAQKLLQLICYPHG...IKECTeGDNLQ..RQHIKRILQNLEQWTLRQSWLELQLMI.........KQCLKDP..GSGSVAEMNNllDNIAKATIEVFQQS........................ADLNNSSNSGMSLFNPNSIGSAD...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     167.53|      56|     158|      16|      88|       2
---------------------------------------------------------------------------
   16-   76 (89.07/86.53)	RPR...LGPpdvYPQDPKQKEDELTAvNVKQGFN.......NQPAFTGDE....HGSARNiVINPSKIGAY.FSSI
 1754- 1824 (78.47/41.37)	KPRsyyLQP...LPLPPEEEEEEPTS.PVSQEPErksaelsDQGKTTTDEekktKGRKRK.TKSSSRVDEYpQSNI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     164.92|      49|     156|     542|     603|       3
---------------------------------------------------------------------------
  545-  593 (80.90/62.39)	GESEVLDEKESISSSSLAGSSLPVFQNVLLRFLDTQAPSLSDPNS.ECEK
  669-  718 (84.02/39.67)	GTTNIFDEVDKSDFKTDFGSEFPIFSPMPGESCENANTSLGRRMSvNCEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     218.58|      61|     156|    1445|    1509|       4
---------------------------------------------------------------------------
 1445- 1505 (96.27/58.35)	GVWLVAPLIARLPTSVQGRVLKAAG.EELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSL
 1608- 1662 (82.35/48.12)	GVLINGTLASDLSNASPG......G.SEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPL
 1668- 1705 (39.96/27.23)	DVITCEPM.GSL...IDTKGNKIAGfDSIDKKQGLQVSTKQK....................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.76|      14|     288|    1548|    1562|       6
---------------------------------------------------------------------------
 1548- 1562 (23.33/21.61)	QMMHEAlQLRL...NLVG
 1837- 1853 (24.43/16.56)	QMMHHP.QSTLwgyNLVG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19933 with Med12 domain of Kingdom Metazoa
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