<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19932

Description Mediator complex subunit 12 like
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLSILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQAPDPNLEWTQISTRYLREQLAKISDFYHMASSTGDGPVPVPPEVEQAMKQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLSLLLSDSPNLLAAHSPHMMIGPNNSSIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNENKSTNPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSSSLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPVGENADEHYSKDHDVKMEEQSIMAHMGIDSGTTNIFDEVDKSDFKTDFGSEFPIFSPMPGESCENANTSLGRRMSVNCEKLVKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTETGVGDEGQKARKNKQETFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACFLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLKNDDFTMRGLRCDGNADDIWTASQNTKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNSSNSGMSLFNPNSIGSADTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRRVIKYEEQHHLLLYHTHPMPKPRSYYLQPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMHHPQSTLWGYNLVGQPQQPGFFLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQGQPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTSQQQAGSVVVSPSYNSRAYPAAHSNPVLMERLRQIQQQPSGYVQQQASPYLQPLTGSQRLNHQALQQSPLVGGGIDAVLTSAHPNLPSVPLPQDPMRPRQPQVRQQQRLLQKQCSPSSPCFPGKACSRPSSSSRQPPWCGSSRSSFPATSHSKE
Length2142
PositionKinase
OrganismPan paniscus (Pygmy chimpanzee) (Bonobo)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Pan.
Aromaticity0.07
Grand average of hydropathy-0.410
Instability index57.48
Isoelectric point7.59
Molecular weight239408.99
Publications
PubMed=22722832

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19932
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     516.64|     167|     203|     909|    1109|       1
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  909- 1107 (260.10/277.04)	SYTTGLCVCIVAVLRRyhsclilnpdqtaQVFeGLCGVVKHVVNPSECSSPerC..............ILAYLYDLYVSCsHLRSKFGDLFS...SACSKVKQTIYNNVMPANSNLRWDPDFMM..DF.IENPSARSI...NYSMLGKILSDNAANRYSFVCNTlmNVCmGHQDAGRINDIANFSSE.LTACCtvlSSEWLGvlkalccssNHVWGFNDVLCT
 1114- 1304 (256.54/185.00)	SFHDSLATFIAILIAR.............QCF.SLEDVVQHVALPSLLAAA..CgdadaepgarmtcrLLLHLFRAPQAC.FLPQATGKPFPgirSSCDRHLLAAAHNSIEVGAVFAVLKAIMMlgDAkIGNNSVSSLkndDFTMRGLRCDGNADDIWTASQNT..KSC.GKSISIETANLREYARYvLRTIC...QQEWVG.........EHCLKEPERLCT
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     670.99|     161|     202|    1673|    1848|       2
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 1500- 1669 (210.65/106.21)	QPFLSLVLT...CLKGQD..EQREG..LL......TSLQNQVnqilSNWReeryqddikarqmMHEALQLRLNLVGGMFDTV...QRSTQWTTDWALLLLQiitsgTVDMHT.NNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKR....SESIDKVRQ..LLPLPKQTC.DV
 1673- 1834 (268.85/142.81)	EPMGSLIDTKGnKIAGFDSIDKKQG..LQ......VSTKQKV....SPWD.............LFEGQKNPAPLSWAWFGTVRVDRRVIKYEEQHHLLLYH.....THPMPK.PRSYYLQPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYS.PI
 1875- 2015 (191.49/109.56)	DPAGSFVPTNT.KQALSNMLQRRSGamMQppslhaITSQQQL....IQMK.............LLQQQQQQRLLRQAQTRPFQQG....QPGDQAALFAAQ.....ARPSPQlP........................QYPGLQQAQTMPQGYTMYGTQMPLQQTSQQQAGSVVVSPSYNSRAY..PAAHSnPV
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.13|      29|     156|     542|     603|       9
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  554-  584 (41.08/69.72)	ESISSSSlAGSS..LPVFQNVLLRFlDTQAPSL
  846-  876 (47.05/10.73)	EQITSFA.SGTSyhLPLAHHIQLIF.DLMEPAL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.29|      12|      29|     767|     778|      10
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  767-  778 (22.36/13.93)	GVGKERDEARHQ
  799-  810 (21.93/13.52)	GVGDEGQKARKN
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      79.79|      22|      29|    2053|    2078|      13
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 2031- 2045 (28.36/ 6.26)	VQQQASPYL.......QPLTGS
 2046- 2061 (21.82/11.24)	......QRLNHQALQQSPLVGG
 2066- 2084 (29.61/17.28)	VLTSAHPNLPSVPLPQDPM...
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.09|      46|    1091|     308|     361|      15
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  308-  361 (74.83/57.48)	DSPNLLAAHSPHM.MIGPNnsSIGAPSPGppgpgmSPVQLAFSDFLSCAQH......GPLV
 1401- 1453 (68.27/34.95)	QSADLNNSSNSGMsLFNPN..SIGSADTS......STRQNGIKTFLSSSERrgvwlvAPLI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19932 with Med12 domain of Kingdom Metazoa
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