<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19925
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MSGVRAVRISIESACEKQVHEVGLDGTETYLPPLSMSQNLARLAQRIDFSQGSGSEEEEAAGTEGDAQDWPGAGSSADQDDEEGVVKFQPSLWPWDSVRNNLRSALTEMCVLYDVLSIVRDKKFMTLDPVSQDALPPKQNPQTLQLISKKKSLAGAAQILLKGAERLTKSVTENQENKLQRDFNSELLRLRQHWKLRKVGDKILGDLSYRSAGSLFPHHGTFEVIKNTDLDLDKKIPEDYCPLDVQIPSDLEGSAYIKVSIQKQAPDIGDLGTVNLFKRPLPKSKPGSPHWQTKLEAAQNVLLCKEIFAQLSREAVQIKSQIPHIVVKNQIISQPFPSLQLSISLCHSSNDKKSQKFATEKQCPEDHLYVLEHNLHLLIREFHKQTLSSIMMPHPASAPFGHKRMRLSGPQAFDKNEINSLQSSEGLLEKIIKQAKHIFLRSRSIQLQLNIGVEQIRVVHRDGRVITLSYQEQELQDFLLSQMSQHQVHAVQQLAKVMGWQVLSFSNHVGLGPIESIGNASAITVASPSGDYAISVRNGPESGSKILVQFPRNQCKDLPKSDVLQDNKWSHLRGPFKEVQWNKMEGRNFVYKMELLMSALSPCLL |
Length | 605 |
Position | Head |
Organism | Pan paniscus (Pygmy chimpanzee) (Bonobo) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae>
Pan.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.425 |
Instability index | 56.07 |
Isoelectric point | 8.01 |
Molecular weight | 67795.68 |
Publications | PubMed=22722832
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP19925
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 261.88| 88| 293| 131| 248| 1
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155- 248 (134.46/135.04) GAAQIllKGAERLTKSVTEN.QENKLQrDFnsELLRLRQHwKLRKVGD..KILG..DLSYRSAGSLFPHH..GTFEVIKNTDLDLDKKI.....PEDYCPLDVQIP
452- 551 (127.41/70.63) GVEQI..RVVHRDGRVITLSyQEQELQ.DF..LLSQMSQH.QVHAVQQlaKVMGwqVLSFSNHVGLGPIEsiGNASAITVASPSGDYAIsvrngPESGSKILVQFP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 107.69| 34| 244| 1| 38| 2
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1- 38 (53.43/46.24) MSGVRAVRISIesacEKQVHEVGLDGT.ETYLPPLSMSQ
251- 285 (54.25/36.08) LEGSAYIKVSI....QKQAPDIGDLGTvNLFKRPLPKSK
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 68.20| 20| 20| 52| 71| 3
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52- 71 (35.80/23.72) GSGSEEEEAAG.TEGDAQDWP
74- 94 (32.39/20.77) GSSADQDDEEGvVKFQPSLWP
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