<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19907

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMAHRTQGKTLLMFTGLLQRVQRTGGAGASMPSLSAPPSKNLHVSKKCFKSFFLFGCPFYWFFFFFFFFFSVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEESKEEDELGYDDDFPVAVEVIVGGVRMVYPSAFVLISQNDIPVPQSVASAGGHIAVGQQGLGSVKDPSNCGMPLTPPTSPEQAILGESGGMQSAASHLVSQDGGMITMHSPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPASNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPNRPPTVSQPGFSAGPSSSSSLPPPASSKHKTTERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDTPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPSNPESSEKWWHSYRLPPSDDAEFRPPELQGERCDAKMEVNSESTALQRLLAQPNKRFKIWQDKQPQMQPLHFLDPLPLSQQPGDSLGEVNDPYTFEDGDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSSSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKMPAVGTEDRPLGKDGRAAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYKDGISSETVTALGMMESPMVSMVSTQLTEFKMEVEDGLGSPKPEEIKDFSYVHKVPSFQPFVGSSMFAPLKMLPSHCLLPLKIPDACLFRPSWAIPPKIEQLPMPPAATFIRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFLEDELDIFGKNSDIGQAAERRLMMCQSTFLPQVEGTKKPQEPPISLLLLLQNQHTQPFASLNFLDYISSNNRQTLPCVSWSYDRVQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLEGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLTDELVSEWFNQPWSGEENDNHSRLKLYAQVCRHHLAPYLATLQLDSSLLIPPKYQTPPAAAQGQATPGNAGPLAPNGSAAPPAGSAFNPTSNSSSTNPAASSSASGSSVPPVSSSASAPGISQISTTSSSGFSGSVGGQNPSTGGISADRTQGNIGCGGDTDPGQSSSQPSQDGQESVTERERIGIPTEPDSADSHAHPPAVVIYMVDPFTYAAEEDSTSGNFWLLSLMRCYTEMLDNLPEHMRNSFILQIVPCQYMLQTMKDEQVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCVVNIALPNRSRRSKVSARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKKLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLYNAIMNIL
Length2177
PositionMiddle
OrganismPan paniscus (Pygmy chimpanzee) (Bonobo)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Pan.
Aromaticity0.08
Grand average of hydropathy-0.380
Instability index58.28
Isoelectric point5.90
Molecular weight239090.19
Publications
PubMed=22722832

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP19907
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     471.23|     107|     112|     787|     893|       1
---------------------------------------------------------------------------
  493-  568 (92.69/37.01)	...........................DKQMAV.PSRN.TSKQMNLNPMD.SP.........HSPISPLP.PTLSPQPRGQETesldPPS.....VPVNPAL.....Y.GN..GLEL.QQLSTLD.DRTVL
  569-  683 (125.94/53.16)	VGQRLPLMAEVsETALYCGIRPSNPesSEKWWHSYRL.....PPSDDAEF.RPpelQGErcDAKMEVNSE.STA..LQRLLAQ....PNKrfkiwQDKQPQMQP.LHF.LDplPLSQ.QPGDSLGEVNDPY
  787-  869 (125.28/52.84)	...........................DELGAVSPALR.SSKMPAVGTED.RP...LGK..DGRAAVPYP.PTVADLQRMFPT....PPS.....LEQHPAFSPVMNY.KD..GISS.ETVTALGMMESPM
  870-  975 (127.32/53.84)	VSMVSTQLTEF.KMEVEDGLGSPKP..EEIKDFSYVHKvPSFQPFVGSSMfAP...LKM.lPSHCLLPLKiPDACLFRPSWAI....PPK.....IEQLP.MPPAATFiRD..GYNNvPSVGSLA......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     344.27|     141|    1266|     123|     384|       2
---------------------------------------------------------------------------
  188-  271 (72.69/100.52)	................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TGQAYKMSDPATRKLieEWQYFYPMVLKKKEESKEEDElgyddDFPVAVeVIVGgvrmvYPSAFVLISQNDIPVPQS..VASAGGH
  288-  360 (91.69/65.00)	CGM.PLTPPTSPEQailGESGGMQSAASHLVSQDGGMITMHSPKRSGKIP..PKLHNHMVHRVWKE.CILNRTQSKR.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
  401-  474 (81.15/ 7.10)	CAVgPNRPPTVSQP...GFSAGPSSSSSLPPPASSKHKTTERQEKGDKLQkrPLIPFHHRPSVAEElCMEQDTPGQK.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1310- 1382 (98.74/19.72)	.............................................................................lglagidsslevsssrkydkqmavpsrntskqmnlnpmdsphspisplpptlspqprgqetesldppsvpvnpalygnglelqqlstlddrtvlvgqrlplmaevsetalycgirpsnpessekwwhsyrlppsddaefrppelqgercdakmevnsestalqrllaqpnkrfkiwqdkqpqmqplhfldplplsqqpgdslgevndpytfedgdikyiftankkckqgtekdslkknksedgfgtkdvttpghstpvpdgknamsifssatktdvrqdnaagragsssltqvtdlapslhdldnifdnsdddelgavspalrsskmpavgtedrplgkdgraavpypptvadlqrmfptppsleqhpafspvmnykdgissetvtalgmmespmvsmvstqltefkmevedglgspkpeeikdfsyvhkvpsfqpfvgssmfaplkmlpshcllplkipdaclfrpswaippkieqlpmppaatfirdgynnvpsvgsladpdylntpqmntpvtlnsaapasnsgagvlpspatprfsvptprtprtprtprgggtasgqgsvkydstdqgspastpsttrplnsvepatmqpipeahslyvtlilsdsvmnifkdrnfdsccicacnmnikgadvglyipdssnedqyrctcgfsaimnrklgynsglfledeldifgknsdigqaaerrlmmcqstflpqvegtkkpqeppislllllqnqhtqpfaslnfldyissnnrqtlpcvswsydrvqadnndywtecfnaleqgrqyvdnptggkvdealvrsatvhswphsnvldismlssqdvvrmllslqpflqdaiqkkrTGRTWENIQHVQGPL..TWQQFHKMAGRGTYGSEESPE.....PLPIPT.LLVG.....YDKDFLTISPFSLPFWERllLDPYGGH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      98.41|      24|      28|    1562|    1587|       3
---------------------------------------------------------------------------
 1545- 1562 (22.37/ 9.02)	......SASGSSVPPV.SSS...ASAPG
 1564- 1587 (42.15/19.52)	SQISTTSSSGFSGSVG.GQN...PSTGG
 1589- 1616 (33.90/13.21)	SADRTQGNIGCGGDTDpGQSssqPSQDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.27|      32|    1266|     123|     156|       4
---------------------------------------------------------------------------
  123-  156 (52.23/47.39)	PVNKSeHLSCAFTFFlHGESNVCTSVEIAQHQPI
 1392- 1423 (59.04/42.89)	PENEA.LLEGAKTFF.RDLSAVYEMCRLGQHKPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.93|      26|      28|    2035|    2062|       5
---------------------------------------------------------------------------
 2035- 2062 (37.05/24.49)	GsHFQhSRSQGERL...LSREAPEELKQQPL
 2065- 2093 (44.88/21.32)	G.YFV.STAKAENLpqwFWSSCPQAQNQCPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.37|      18|      28|    1986|    2008|       6
---------------------------------------------------------------------------
 1986- 2008 (25.52/25.53)	SPNNDdmfvDLPFPDDmDNDIGI
 2017- 2034 (34.86/17.28)	SPNSS....PVPSPGS.PSGIGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.10|      23|      27|    1707|    1733|       7
---------------------------------------------------------------------------
 1711- 1733 (43.93/35.19)	IQYLKSM..AFSVYCQCR...RPLPTQI
 1735- 1762 (29.17/11.32)	IKSLTGFgpAASIEMTLKnpeRPSPIQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.34|      12|      27|    1840|    1851|      10
---------------------------------------------------------------------------
 1840- 1851 (24.58/14.81)	KIGLQKLWEWCI
 1870- 1881 (22.75/13.15)	RLGHGELKDWSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     202.87|      63|     434|    1477|    1541|      11
---------------------------------------------------------------------------
 1477- 1541 (101.75/51.33)	LAPYLATLQLDSSLLIPPKYQTpPAAAQGQATPGN..AGPLAPNGSAAPPAGSAFnPTSNSSSTNPA
 1913- 1977 (101.11/44.20)	LSACLVAMEPQGSFVVMPDAVT.MGSVFGRSTALNmqSSQLNTPQDASCTHILVF.PTSSTIQVAPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.86|      19|      25|    1664|    1683|      13
---------------------------------------------------------------------------
 1664- 1683 (31.05/28.65)	NFWLLSLMRCyTEMLDNLPE
 1687- 1705 (34.81/25.46)	NSFILQIVPC.QYMLQTMKD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19907 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) APSLHDLDNIFDNSDDDELGAVSPALRSSKMPAVGTEDRPLGKDGRAAVP
2) CAVGPNRPPTVSQPGFSAGPSSSSSLPPPASSKHKTTERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDTPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLEL
3) ECILNRTQSKRSQMSTPTLEEEPASNPATWDFV
4) EKWWHSYRLPPSDDAEFRPPELQGERCDAKMEVNSESTALQ
5) GILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPE
6) GTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSSSLTQVTD
7) KDPSNCGMPLTPPTSPEQAILGESGGMQSAASHLVSQDGGMITMHSPKRSGKIPPKLH
8) PPKYQTPPAAAQGQATPGNAGPLAPNGSAAPPAGSAFNPTSNSSSTNPAASSSASGSSVPPVSSSASAPGISQISTTSSSGFSGSVGGQNPSTGGISADRTQGNIGCGGDTDPGQSSSQPSQDGQESVTERERIGIPTEPDSADS
9) VGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQ
771
401
350
597
2007
703
283
1493
971
820
556
382
637
2055
769
340
1637
1068










Molecular Recognition Features






MoRF SequenceStartStop




NANANA