<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19895

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVSFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHVDPFMGDPFSLFPPEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYTEKLAMFMFQVEIVVLFIFSFTLSDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVISAQSTSTLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDAEHKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGILYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKNKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPADPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQAGVRSTQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQPQSQPQVAAGLQPQAQGQLPRLGTQPVNWVGDSME
Length2122
PositionKinase
OrganismPan paniscus (Pygmy chimpanzee) (Bonobo)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Pan.
Aromaticity0.07
Grand average of hydropathy-0.431
Instability index53.68
Isoelectric point6.39
Molecular weight235958.46
Publications
PubMed=22722832

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19895
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      68.45|      15|      15|    2047|    2061|       1
---------------------------------------------------------------------------
 2050- 2065 (26.99/11.26)	QQQQQ.QQQQQQQqQQQ
 2066- 2077 (20.70/ 6.83)	QQQQQ.QQHQQQQ....
 2089- 2104 (20.77/ 6.88)	QSQPQvAAGLQPQ.AQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     883.64|     221|     231|     372|     600|       2
---------------------------------------------------------------------------
  160-  368 (259.26/132.67)	.......................IKMTC.......AYY..AAIS.ETK..VKK.RHVDPFMGDPFSLFPP.........EWTQIITKYLWEQLQKMAEYYRP.GPA.....G..SGGC.....GSTIGPLPHDVEVairqwdytekLAMFMFQVEivvlfIFSFTLsDGMLDRHEF.LTWVLECFEkIRPGEDELLKLLLPLLL......RYSGE...FVQSAYLSRR.LAYFCTRRLAlQL..DGVSSHSShvISAQSTSTlPTTPAPQPPTSSTP...STP
  372-  600 (360.70/203.64)	LLMCPQ...HRPLVFGLscilqtILLCCP...SALVWH..YSLT.DSR..IKTGSPLDHLPIAPSNLPMP.........EGNSAFTQQVRAKLREIEQQIKERGQAVEVRWS..FDKCQEatAGFTIGRVLHTLEV..........LDSHSFERS.....DFSNSL.DSLCNRIFG.LGPSKDGHE.ISSDDDAVVSLLCEWAV....SCKRSGRHRAMVVAKLLEKR.QAEIEAERCG.ES..EAADEKGS..IASGSLSA.PSAPIFQDVLLQFL...DTQ
  603-  836 (263.67/136.39)	MLTDPRsesERVEFFNL......VLLFCElirHDVFSHnmYTCTlISRgdLAFGAP...GPRPPSPFDDPaddaehkeaEGSSS.........SKLEDPGLSESMDIDPSSSvlFEDMEK..PDFSLFSPTMPCEG..........KGSPSPEKP.....DVEKEVkPPPKEKIEGtLG........ILYDQPRHVQYATHFPIpqeeSCSHECNQRLVVLFGVGKQRdDARHAIKKIT.KDilKVLNRKGT..AETDQL.A.PIVPL.NPGDLTFLggeDGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.98|      15|      15|     876|     890|       3
---------------------------------------------------------------------------
  876-  890 (26.85/19.98)	LEQITSFALG.MSYHL
  892-  907 (23.14/16.02)	LVQHVQFIFDlMEYSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     319.12|      77|     233|    1165|    1241|       6
---------------------------------------------------------------------------
 1165- 1241 (130.52/64.85)	LLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKT.PQLNPCQSDG...NKPTVG.IRSSCDRHLLAASQNRIVDG
 1318- 1382 (97.38/46.60)	......RC..LKSLCEDSNDLQDPVLSSAQAQR.LMQLICY.PHRLLDNEDG...ENPQ....RQRIKRILQNLDQWTMRQS
 1401- 1477 (91.21/43.20)	LLENIAK.ATIEVFQQSA..ETGSSSGS..TASNMPSSSKTkPVLSSLERSGvwlVAPLIAkLPTSVQGHVLKAAGEELEKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.95|      16|      20|    1681|    1700|       7
---------------------------------------------------------------------------
 1681- 1700 (15.95/28.23)	IDTKgNKIAGFDsIFkkEGL
 1702- 1717 (31.00/22.73)	VSTK.QKISPWD.LF..EGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.70|      14|      23|    1584|    1597|       8
---------------------------------------------------------------------------
 1584- 1597 (24.50/18.42)	LLEIIISGTV..DMQS
 1608- 1623 (20.20/13.63)	MLSVLINGTLaaDMSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     129.75|      18|      20|    1988|    2005|      10
---------------------------------------------------------------------------
 1875- 1892 (23.80/11.67)	GPRVDPYRPVRLPMQKLP
 1913- 1926 (21.95/10.00)	PSSY...KTSVY.RQQQP
 1943- 1958 (24.08/11.93)	QSQGMLGQSS..VHQMTP
 1988- 2005 (34.03/20.99)	PTRHLQQRPSGYVHQQAP
 2009- 2026 (25.89/13.58)	HGLTSTQRFSHQTLQQTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     142.95|      33|     147|     947|     981|      11
---------------------------------------------------------------------------
  947-  981 (55.21/38.24)	LCivAVL.RHYHACLILNQDQMAQVFEGLCGVVKHG
  996- 1024 (34.11/16.67)	....AYLyDLYTSCSHL.KNKFGELFSDFCSKVK..
 1100- 1129 (53.63/31.36)	LC..AEL.TGY..CKSLSAEWLG.VLKALCCSSNNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.90|      10|      24|    1776|    1785|      13
---------------------------------------------------------------------------
 1776- 1785 (17.65/ 9.06)	APTLLEPEKK
 1798- 1807 (18.25/ 9.66)	APPSTEERKK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19895 with Med12 domain of Kingdom Metazoa
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