<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19894

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVSFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHVDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYTEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVISAQSTSTLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDAEHKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGILYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKNKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQAGVRSTAILPEQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY
Length2177
PositionKinase
OrganismPan paniscus (Pygmy chimpanzee) (Bonobo)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Pan.
Aromaticity0.07
Grand average of hydropathy-0.512
Instability index57.69
Isoelectric point6.63
Molecular weight243066.70
Publications
PubMed=22722832

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19894
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     259.27|      36|      37|    2050|    2085|       1
---------------------------------------------------------------------------
 1899- 1940 (34.90/10.91)	.RQQQPAVPQGQRLRQQLQQSQGmlGQSSVHqMTPsssyGLQT
 1992- 2023 (41.04/14.28)	...QQRPSGYVHQQAPTYGHGLT..STQRFS.H.Q....TLQQ
 2024- 2085 (59.19/24.23)	EQQQQQQQQQQQQQQQQQQQQQQ..QQQQYH.IRQ....QQQQ
 2088- 2116 (51.30/19.90)	LRQQQQQQQQQQQQQQQQQQQQQ..QQQQQH............
 2117- 2144 (45.27/16.59)	.......QQQQQQQAAPPQPQPQ..SQPQFQ..RQ....GLQQ
 2145- 2168 (27.57/ 6.89)	TQQQQQTAALVRQLQQQLSNTQP..Q.................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     730.44|     207|     231|     349|     577|       2
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  216-  345 (129.78/71.39)	.............................................................................................................................GSTIGPLPHDVEV....AIRQWDYTEKLamfmfqDGMLDRHEF.LTWVLECFEkIRPGEDELLKLLLPLLL......RYSGE...FVQSAYLSRR.LAYFCTRRLAlQL..DGVSSHSShvISAQSTSTlPTTPAPQPPTSSTP...STP
  349-  577 (326.48/254.35)	LLMCPQ...HRPLVFGLscilqtILLCCPsaLVWH.......YSLT.DSR..IKTGSPldhLPIAPSNLPMP.........EGNSAftqqvraklREIEQQIKERGQAVEVRWS..FDKCQEatAGFTIGRVLHTLEVLDSHSFERSDFSNSL......DSLCNRIFG.LGPSKDGHE.ISSDDDAVVSLLCEWAV....SCKRSGRHRAMVVAKLLEKR.QAEIEAERCG.ES..EAADEKGS..IASGSLSA.PSAPIFQDVLLQFL...DTQ
  580-  813 (274.18/173.75)	MLTDPRsesERVEFFNL......VLLFCE..LIRHdvfshnmYTCTlISRgdLAFGAP...GPRPPSPFDDPaddaehkeaEGSSS.........SKLEDPGLSESMDIDPSSSvlFEDMEK..PDFSLFSPTMPCEGKGSPSPEKPDVEKEV.....kPPPKEKIEGtLG........ILYDQPRHVQYATHFPIpqeeSCSHECNQRLVVLFGVGKQRdDARHAIKKIT.KDilKVLNRKGT..AETDQL.A.PIVPL.NPGDLTFLggeDGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     800.03|     201|     204|    1233|    1436|       3
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 1034- 1239 (234.14/141.83)	FTYTGLGKSLSENPANR.YSfvcnalmhvcVGHHDPDRvnDI..AILCAELTGYCKSL.....SAEWLG..VLKALCCSSNNgtcgFND.LLCNVDVSDLSfhdSLATFVAILI...............ARQCL..LLEDLircaaipsllnaacsEQDSEPGARLTCRILLHLF....KTPQLNP....CQSDGNKPTVGI..........RSSCDRHLLAASQNRIVDGAV..FAVLK..AVFVLG..DAELKGSG
 1240- 1443 (324.15/209.64)	FTVTGGTEELPEEEGGG.GS..........GGRRQGGR..NI..SVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSND....LQDpVLSSAQAQRLM...QLICYPHRLLD.......NEDGenPQRQRIKRILQNL...............DQWTMRQSSLELQLMIKQT....PNNEMNS....LLENIAKATIEVFQQSAETGSSSGSTASNMPSSSKTKPVLSSLERSGVWL..VAPLIAKLPTSVQGHV
 1444- 1642 (241.74/146.71)	LKAAG..EEL..EKGQHlGS..........SSRKERDR..QKqkSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQ....I...VNNWRDDQYLD...D..CKPKQLMHealklrlNLVG..GMFDTVQRSTQQT...............TEWAM....LLLEIIISGTvdmqSNNELFTtvldMLSVLINGTLAADMSSISQGSMEENKRAYMNLAKKLQKELG..ERQSDSLekVRQLL.PLP.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.98|      15|      15|     853|     867|       4
---------------------------------------------------------------------------
  853-  867 (26.85/16.27)	LEQITSFALG.MSYHL
  869-  884 (23.14/13.01)	LVQHVQFIFDlMEYSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.86|      15|      19|    1660|    1678|       7
---------------------------------------------------------------------------
 1660- 1678 (14.83/20.11)	TKgNKIAGFDsIFkkEGLQ
 1681- 1695 (30.03/16.00)	TK.QKISPWD.LF..EGLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.51|      33|     105|    1844|    1880|       8
---------------------------------------------------------------------------
 1790- 1830 (47.97/19.20)	KKRSQPAtktedyGmGPgRSGPY.GVTVP.PDLLHHPN.PGSIT
 1844- 1879 (53.53/38.07)	QNQPLPA......G.GP.RVDPYrPVRLPmQKLPTRPTyPGVLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.91|      19|      64|    1962|    1980|      10
---------------------------------------------------------------------------
 1941- 1966 (28.05/11.87)	SQGYTPYVShvglqQHTGPagTMVPP
 1967- 1987 (31.87/14.45)	SYSSQPYQS.....THPSTnpTLVDP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19894 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGI
2) GAPGPRPPSPFDDPADDAEHKEAEGSSSSKLEDPGLSESMDIDPSSSV
3) KRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSA
4) RAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQAGVRSTAILPEQQQQQQQQQQ
687
627
15
1735
724
674
59
2060










Molecular Recognition Features






MoRF SequenceStartStop




1) MAAFGI
2) NIFGRY
3) QQYHIRQQQQQQILRQQ
1
2172
2075
6
2177
2091