<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19841

Description Mediator of RNA polymerase II transcription subunit 19 (Fragment)
SequenceXRHGDSAGAEGTMENFTALFGAQADPPPPPTALGFGPGKPPPPPPPPAGGGPGTAPPPTAATAPPGADKSGAGCGPFYLMRELPGSTELTGSTNLITHYNLEQAYNKFCGKKVKEKLSNFLPDLPGMIDLPGSHDNSSLRSLIEKPPILSSSFNPITGTMLAGFRLHTGPLPEQCRLMHIQPPKKKNKHKHKQSRTQDPVPPGKPS
Length206
PositionHead
OrganismHomo sapiens (Human)
KingdomMetazoa
Lineage
Aromaticity0.05
Grand average of hydropathy-0.640
Instability index58.95
Isoelectric point9.30
Molecular weight21470.26
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19841
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.72|      13|      14|      21|      34|       1
---------------------------------------------------------------------------
   21-   34 (23.82/ 7.48)	GAQADPPPPPtALG
   38-   50 (31.90/ 8.51)	GKPPPPPPPP.AGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.39|      14|      38|      79|      92|       2
---------------------------------------------------------------------------
   79-   92 (24.74/12.19)	LMRELPGSTELTGS
  120-  133 (27.66/14.42)	FLPDLPGMIDLPGS
---------------------------------------------------------------------------











Associated diseases
Disease
prostate cancer	PMID:31715665 PMID:28125713
tongue cancer	PMID:23705783
breast cancer	PMID:30161287 PMID:27572702 PMID:20890603 PMID:30583076
gastric cancer	PMID:22565189
lung cancer	PMID:25735376
bladder cancer	PMID:21478038 PMID:23276457 PMID:28631286
cervical cancer	PMID:30473219
bone metastasis	PMID:23276457



























Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19841 with Med19 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PEQCRLMHIQPPKKKNKHKHKQSRTQDPVPPGKPS
2) XRHGDSAGAEGTMENFTALFGAQADPPPPPTALGFGPGKPPPPPPPPAGGGPGTAPPPTAATAPPGADKSGAGCGPFY
172
1
206
78










Molecular Recognition Features






MoRF SequenceStartStop




NANANA