<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19839

Description Mediator complex subunit 14
SequenceMAPVQIGSDGQLVPAGGPTSTPQPPPGAPATQGVRLSLLIEFLLQRTYHEITLLAELLPRKTDMERKIEIVQFASRTRQLFVRLLALVKWASNAGKVEKCAMISSFLDQQAYLFVDTADRLASLARDALVHARLPSFAIPFAIDVLTTGSYPRLPTCIRDKIIPPDPITKAEKQTTLNQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDGRALVHSMQVNYIHELVQSRLFGDDKPLQDMYTCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYIPAKCLTLSVWNQQVLGRKTGTASVHKVTIKIDESDGSKPLQISHEPPLPACDSKLMERAMKIDHLSVEKLLIDSVHARSHQKLQELKAILKSSNPNDNSFIETALPTLVIPILEPCGRSECLHIFVDLHSGMFQPMLYGVDQSMLDDIEKSINDDMKRIVTWLLQLKFWLGEQRCRQSVKHLPTLCTDTLHLSNLTTHPVGNLSKHRLFIKLTRLPQYYIVNTLNILFIYLTDKTVICVNSKQLTFVFFKVVEMFDVPSNLTELQYKYYFLSVSQMESEDGLPSAQLFRHFKPNLEELVQDISSCRMVRPGTKRKLSGEQSAVEPKKPKRSGEMCAFNKELAHLVAMCDTNMPLIGLRSELSNMEIPHQGVQVEGDGCSHAIRILKVPPCMAVGEETRKALERSLLDCTFRLQGRNNRTWVAELIFSSCPLNSTSIKEQASTRHVYLTYENPLSEPVGGRKVVEMFLNDWNSISKLYECVLEFSRSLTEMPSYLSLFSEIRLYNYRKLVLCYGSTKGSSVTIQWNSVTHRYHLALGTVGPNSGCSNCHNIILHQLQEMFNKTPNVVQLLQVLSDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNTKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPISMEDTFMPHTQTQPPGRGVYPPLTSPPNPYHVPPSPSMITTQSPGNIHAANSPSGALRAPSPFGPTPSPSSLGISMGQTSNFASPHGTLDPSSPYTLVSASPRVGPWPGSPQVSGPSPGARIPGMSPGNPSLHSPIPDPSHSPRAGTSSQAMPPPRKLPQRSWAASIPTILTHSKLHVLLLPSPMPCPVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQLEPNLTIVNSNEPGVIMFKTEVLKCRVALNPKSYQTLQLKVTPENTGPWSQEELQVLEKFFETRVAGPPFKYNTLNAFTKLLGAPTNILRDCVRIMKLELFPDQAAQLNWNVQFCLTIPPSAPPIAPPGTIAVVLKTKMLFFLQLTQRLPVPQEPISIIVPIVYDMATGLTQQADIPRQHSSSGAAALMVSSILRRFNEHHPPRPGECTIFAAVHELMANLTLNSGGRP
Length1451
PositionTail
OrganismDanio rerio (Zebrafish) (Brachydanio rerio)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Cypriniformes> Danionidae> Danioninae> Danio.
Aromaticity0.07
Grand average of hydropathy-0.164
Instability index51.23
Isoelectric point8.74
Molecular weight161652.27
Publications
PubMed=23594743

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
blood vessel morphogenesis	GO:0048514	IMZFIN
brain development	GO:0007420	IMZFIN
embryonic viscerocranium morphogenesis	GO:0048703	IMZFIN
neural crest cell differentiation	GO:0014033	IMZFIN
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central
stem cell population maintenance	GO:0019827	IMZFIN
ventricular system development	GO:0021591	IMZFIN

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP19839
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      81.25|      14|      15|    1027|    1040|       1
---------------------------------------------------------------------------
 1027- 1040 (33.75/13.53)	TSPPNPYHVPPSPS
 1044- 1057 (21.89/ 6.20)	TQSPGNIHAANSPS
 1060- 1073 (25.62/ 8.50)	LRAPSPFGPTPSPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     126.57|      28|      29|    1118|    1145|       2
---------------------------------------------------------------------------
 1118- 1145 (58.60/28.46)	GPSP.GARIPGMSPGNPSLHSPIPDP.SHS
 1149- 1177 (41.27/17.55)	GTSS.QAMPPPRKLPQRSWAASIPTIlTHS
 1184- 1204 (26.71/ 8.39)	LPSPmPCPVPGLA.G.SYLCSPL.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      69.76|      16|      19|     554|     569|       3
---------------------------------------------------------------------------
  536-  551 (22.37/13.91)	VNTL....NILFIYLTDKTV
  554-  569 (25.63/17.05)	VNSK....QLTFVFFKVVEM
  572-  591 (21.75/13.31)	VPSNltelQYKYYFLSVSQM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.21|      18|      29|     147|     166|       4
---------------------------------------------------------------------------
  147-  166 (29.48/19.83)	TTgsYPRLPTCIRDKII....PPD
  175-  196 (25.72/11.09)	TT..LNQLNQILRHRLVttdlPPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     154.80|      45|     149|     280|     325|       7
---------------------------------------------------------------------------
  280-  325 (77.07/62.95)	CLHSFCLSLQLEvLHSQTL..MLIRERWGDLVQVERYIPAKCLTLSVW
  431-  477 (77.73/58.44)	CGRSECLHIFVD.LHSGMFqpMLYGVDQSMLDDIEKSINDDMKRIVTW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.15|      31|     838|     500|     531|       8
---------------------------------------------------------------------------
  500-  531 (52.03/33.90)	LCTdTLHLSNLTTHPVGNL.....SKHRLFIKLT.RLP
 1336- 1372 (49.12/27.18)	FCL.TIPPSAPPIAPPGTIavvlkTKMLFFLQLTqRLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.92|      12|      15|    1086|    1097|       9
---------------------------------------------------------------------------
 1086- 1097 (24.33/12.32)	ASPHGTLDPSSP
 1103- 1114 (26.60/14.25)	ASPRVGPWPGSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.75|      13|      15|    1277|    1291|      10
---------------------------------------------------------------------------
 1277- 1291 (19.48/17.59)	QVLEKFfeTRVAGPP
 1295- 1307 (20.28/10.56)	NTLNAF..TKLLGAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.85|      21|      28|     775|     796|      12
---------------------------------------------------------------------------
  775-  796 (34.98/29.90)	RKVVEM..FLNDWNSIsKLY...ECVL
  800-  825 (25.86/15.96)	RSLTEMpsYLSLFSEI.RLYnyrKLVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.70|      18|      20|     866|     884|      13
---------------------------------------------------------------------------
  866-  884 (27.00/21.65)	ILHQLQ...EMFNKTPnVVQLL
  886-  906 (25.70/14.93)	VLSDTQaplNAINKLP.TVPML
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.62|      11|      28|     645|     658|      14
---------------------------------------------------------------------------
  645-  658 (12.44/22.16)	RSgEMCafNKELAH
  673-  683 (21.19/14.86)	RS.ELS..NMEIPH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.24|      15|      27|     232|     246|      16
---------------------------------------------------------------------------
  232-  246 (22.88/17.17)	LLKLEILVEDKETGD
  262-  276 (25.36/20.01)	LVQSRLFGDDKPLQD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19839 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NQDARRRSVNEDDNPPSPISMEDTFMPHTQTQPPGRGVYPPLTSPPNPYHVPPSPSMITTQSPGNIHAANSPSGALRAPSPFGPTPSPSSLGISMGQTSNFASPHGTLDPSSPYTLVSASPRVGPWPGSPQVSGPSPGARIPGMSPGNPSLHSPIPDPSHSPRAGTSSQAMPPPRKLPQ
985
1163










Molecular Recognition Features






MoRF SequenceStartStop




NANANA