<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19836

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMMAAFGVLSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNSSKISSNFSSIIAEKLRCNTFPDTGKRKPQVNQKDNFWLVTARSQSSINNWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYSVPVMRSAWMIKMTCAYHAAITENKMKKRHVIDPCIEWTQIITKYLWEQLQKVAEFYRQSPSQGCGSPLPAPPAEVETAMKQWEYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLRLLLPLLLQYSGEFVQSAYLSRRLAYFCTRRLNLLLSDGSIGPGPGGHQAHGISAQQGNALPPTPTSQPAGGNQPQTPFTDFYICPQHRPVVFGLSCMLQSIVLCCPSALVWHYSLTDSRNKTGSPLDLLPIAPSNLPMPGGNSTFNQQVRAKVREIEEQIKERGQAVEFRWSFDKCQETTAGFTISRVLHTLEVLDNHSFEKSDFSNSLDSLYNRIFGSGQSKDGHEMSPDDDAVVTLLCEWAVSCKRSGPHRAMVVAKLLEKRQTEIEAERCGESEVVDEKGSVSSGSLSAATLPVFQDVLLQFLDTQAPVLTEPGNESERVEFSNLVLLFYELIRHDVFSHNIYMCTLISRGDLASNSHLPRPRSPSDEPSDESERKDQDAGSSVKIEDTGMSESMEIDHNSSANFDEMFSPPMHCESKGSPSPEKQAQEQESKSTAKDKGMDPAFPLVYEQPRHIQYATHFPIPQEESASHECNQRLVVLYGVGKQRDEARHAIKKITKDILKVLNRKSTAETGGEEGQKRKRSKPEAFPTAEDIFSKFQHLSHFDQHQVTSQVSRNVLEQITSFALGMSYHLPLVQHIQFIFDLMEYSLNISGLIDFAIQLLNELSLVEAELLLKSSNLAGSYTTGLCLCIVAVLRRYHSCLILNPDQTAQVFDGLRIVVKSGVNPADCSSAERCILAYLYDLYTSCSHLKSKFGEIFSEFCSKVKNSIYYNIDPSDSNMLWDQMFMIDAITNPTAHNLNHSMLGKITNELNDSPANRYSFVCNVLMDVCVDHRDPERVNDIGILCAELTAYCRSLSAEWLGVLKALCCSSNNGNCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLVRCVAIPSLLNAACSEQDSEPGARLTCRILLHLFRTPQRNPCPQDGTKSDKSIVGIRSSCDRHLLAASQNSIVVGAVFAVLKAVFMLGDAELKGSGFSHPAGLDDIGEDDMGSKKSGGRNVSIETASLVVYAKYVLKSICHQEWVGERCLKSLSEDSSALQDPVLVNIQAQRLLQLICYPHRQLDSEEGDNPQRQRIKRILQNMDQWTMRQSSLELQLMIKQSSNNELYSLLENIAKATIEVFQKSAEMNSSNPSWNGSAVSGSSVSNSNSASKLKPVLSSSERSGVWLVAPLIGKLPTSVQGHVLKAAGEELEKGQHLGPSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVQQIVTNWREDQYQDDCKAKQMMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLDIISSGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGDRQSESLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFEKEGLQVSTKQKISPWDVFEGLKHSAPLSWGWFGTIRVDRKVTKFEEQQRLLLYHTHIKPKQRSYYLAPLNLPQEEEEPLTPVPPEPDKKLDTAKVEKSVSNVPTKKKKKKPASTVKQEDYKPHNTVMQYAPGMTPDLPLSMGQTNMSYRMGYQAPMNMYAQNQPLPPGGPGLEPPFRPRVPMNKMPPRPNYTMPNMQTAGMGNLMGMEKQYQMNYKPMPNMAQGQMLRHQLQGHNHLIGQQIRQVTPNPQYSSMQPAQNIPQGYTSYGSHMGMQPHPSQTPGMVPNSYGNQGFQTGHPATNPTMVDSIRQMQQRPGYVHQQAPAAYGHTIQSTQRFPHQSMQQTPMMHGLAQSHLGVQGIHPNMRPNQMMEQQQQQQQQQQQQQQQQQQQQVHQQQQHIRQGPVFRVSAHSQHQSHCLVQQQVQPQQVQQQQVQQQQQQVSAAQPPAQALGMQALPPQQPMFQRQGMQQTQQQQQTAALVRQLQQQLSSMYSNYHDMHCYPHPCLIHTAAFLKNIFLVYKIILPS
Length2188
PositionKinase
OrganismDanio rerio (Zebrafish) (Brachydanio rerio)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Cypriniformes> Danionidae> Danioninae> Danio.
Aromaticity0.07
Grand average of hydropathy-0.497
Instability index55.47
Isoelectric point7.00
Molecular weight245671.71
Publications
PubMed=23594743

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19836
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     204.08|      27|      27|    1974|    2000|       1
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 1821- 1865 (24.49/ 7.46)	MYAQNQPL.P.....PggpgleppfrprvpmnkM..PPRPNYtMP.NMQTA.GMG
 1866- 1898 (23.81/ 7.01)	NLMGMEKQ.YqmnykP..............mpnM..AQGQML.RH.QLQ...GHN
 1932- 1952 (31.46/12.05)	SHM.GMQ........P................hP..SQTPGM.V.....PN.SYG
 1953- 1990 (36.71/15.52)	N..QGFQTgH.....P.....atnptmvdsirqM..QQRPGY.VH.QQAPA.AYG
 1991- 2019 (39.68/17.47)	HTIQSTQR.F.....P..............hqsM..QQTP.M.MH.GLAQS.HLG
 2021- 2047 (23.39/ 6.73)	QGIHPNMR.......P...............nqMmeQQQQQQ.QQ.QQQQQ....
 2079- 2114 (24.54/ 7.49)	HCLVQQQV.Q.....P..........qqvqqqqV..QQQQQQ.VSaAQPPAqALG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     185.80|      44|      82|     702|     745|       2
---------------------------------------------------------------------------
  650-  700 (45.10/19.97)	SERKDQDAGSSVKieDTGMSE.SmeidhnssanFDEMFSPPMHCE.SKGSPSP....
  702-  745 (76.93/39.26)	KQAQEQESKSTAK..DKGMDP.A..........FPLVYEQPRHIQYATHFPIPQEES
  785-  829 (63.77/31.28)	KSTAETGGEEGQK..RKRSKPeA..........FPTAEDIFSKFQHLSHFDQHQVTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.55|      15|      83|    2048|    2064|       3
---------------------------------------------------------------------------
 2048- 2062 (30.34/ 9.08)	QQQQQQQ.....VHQQQQHI
 2131- 2150 (22.21/ 6.68)	QQTQQQQqtaalVRQLQQQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     235.03|      69|      94|     305|     377|       4
---------------------------------------------------------------------------
  305-  377 (118.89/79.74)	LNLLLSDGSIGPGPGGHQAHGisaQQGNALPPTPTSQPAGGNQPQTPFTDFYICpQHRPVVFGLSCMLQSI.VL
  400-  469 (116.15/66.98)	LDLLPIAPSNLPMPGGNSTFN...QQVRAKVREIEEQIKERGQAVEFRWSFDKC.QETTAGFTISRVLHTLeVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     150.04|      41|      56|    1173|    1225|       6
---------------------------------------------------------------------------
 1173- 1215 (63.03/42.46)	PCPQD..GTKSDKSIVGIRSSCDRHlLAASQNSIVVGAVFaVLKA
 1232- 1270 (61.88/47.57)	PAGLD..DIGEDD..MGSKKSGGRN.VSIETASLVVYAKY.VLKS
 1272- 1298 (25.13/ 7.50)	.CHQEwvGERCLKSL.....SEDS...SALQDPVLV.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.33|      21|      96|    1633|    1655|       7
---------------------------------------------------------------------------
 1608- 1628 (32.74/18.43)	MNLVKKLRKELGDRQSESL..EK
 1633- 1655 (32.59/24.47)	LPLPKQTRDVITCEPQGSLidTK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.75|      19|      30|     947|     968|       9
---------------------------------------------------------------------------
  947-  968 (28.59/27.15)	CSSAERCIlaYlYDLYTSCSHL
  980-  998 (36.17/22.12)	CSKVKNSI..Y.YNIDPSDSNM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      86.56|      22|      57|    1082|    1103|      10
---------------------------------------------------------------------------
 1032- 1046 (18.92/ 7.12)	....SPANRYSF....VCNV......................................LMD
 1047- 1084 (18.02/ 6.40)	VCVDHRDPERVNDiGILC.A......................eltaycrslsaewlgvLKA
 1085- 1144 (21.81/ 9.45)	LCCSSNNGNCGFN.DLLCNVdvsdlsfhdslatfvailiarqcllledlvrcvaipslLNA
 1145- 1164 (27.82/14.28)	.ACSEQDSEPG.A.RLTCRI......................................LLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      89.20|      16|      52|     841|     856|      11
---------------------------------------------------------------------------
  841-  856 (28.37/16.04)	SFALG.MSYHLPLVQHI
  857-  873 (18.17/ 7.58)	QFIFDlMEYSLNISGLI
  874-  889 (19.07/ 8.33)	DFAIQ.LLNELSLVEAE
  894-  909 (23.58/12.07)	SSNLA.GSYTTGLCLCI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19836 with Med12 domain of Kingdom Metazoa
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