<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19829

Description Mediator of RNA polymerase II transcription subunit 25
SequenceMDPTSKSGLNQVSDVVFVIEGTANLGPYFESLRNNYILPTIEYFNGGPPAETDFGGDYGGTQYGLVVFNTVDCAPESYVQCHAPTSSAFEFVSWIDSIQFMGGGAESCSLIAEGLSVALQLFDDFKKMREQIGQTHKVCVLLCNSPPYLLPAVESVSYTGCTADSLVQIIRDRGIHFSVIAPRKLPALRSLFERASSVAGPPESSHPDYSQDPFHMVLVRGIALPVAPGGGSVPVSLKPVLPPQSLPVNQNPLVPVASTAPQMNTFQNVSLHAAHDAAQKALEEAANQQQKNRFGQISTPPFSQSPVLPPGGKPSLSTVTTVSPPVLTQQQVPPQQPQQQTQVPQPGLPAVNQQPPQASQQQPNNQQTPPPTQPGMAAVPAPPPGAQQGVANKVVAWSGVLEWQEKPKASSMDSNTKLTRSLPCQVQVSQGENLNTDQWPQKLIMQLIPQQLLVNINIHFNPVFKCNREVVWIGTYFDMMYILCLYVCMCAGCVHFPHSAPCEVRVLMLLYSSRKRIFMGLIPNDQSGFVNGIRQVITNHKQVQQQRSMQPGQVQPNQNFLNRPPGPIPVTHGNVPQQLRAAATGNQQAPVTGAPPNQVQGQAQAPGGGMLRLQNPGANPQLRSLLLSQQPVSVRQVLGLHNISFQHCQMVHAAPGGGAQMQPQWRQPHQGPLMVPTGPRGPVTQNPGMPSVSSVMEDEILMDLI
Length705
PositionUnknown
OrganismDanio rerio (Zebrafish) (Brachydanio rerio)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Cypriniformes> Danionidae> Danioninae> Danio.
Aromaticity0.06
Grand average of hydropathy-0.248
Instability index56.03
Isoelectric point7.23
Molecular weight76192.12
Publications
PubMed=23594743

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19829
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.00|      24|      25|     333|     356|       1
---------------------------------------------------------------------------
  320-  351 (38.91/11.37)	TTvSPPvltqqqvPPQQP.QQQTQVP.QPGLPAV
  352-  379 (31.09/ 7.53)	NQ.QPP.....qaSQQQPnNQQTPPPtQPGMAAV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     109.16|      31|     125|     420|     452|       2
---------------------------------------------------------------------------
  420-  449 (44.09/20.94)	................................................RSL.PCQVQVSQgENLNTDQWPQKLIMQLIP
  450-  523 (24.29/ 7.49)	QQllvninihfnpvfkcnrevvwigtyfdmmyilclyvcmcagcvhfpHSA.PCEVRVLM..LLYSSR..KRIFMGLIP
  526-  576 (40.78/15.47)	QS...........................gfvngirqvitnhkqvqqqRSMqPGQVQPNQ.NFLNRPPGPIPVTHGNVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     282.18|      50|      69|     577|     626|       3
---------------------------------------------------------------------------
  194-  261 (58.61/19.54)	R.......ASSVAGPPESSHPDYSQDPFHMvlvR....GIALpvAPGG..GSVPVslkpvlppqslpvnQNPLV.PVASTAP
  262-  319 (58.07/19.29)	QmntfqnvSLHAAHDAAQKALEEAA..NQQ...QknrfGQIS..TPPF..SQSPV..............LPPGGKPSLSTV.
  577-  626 (86.40/32.20)	Q.......QLRAAATGNQQAPVTGAPPNQV...Q....GQAQ..APGG..GMLRL..............QNPGANPQLRSLL
  649-  696 (79.10/28.88)	Q.......MVHAAPGGGAQMQPQWRQPH.....Q....GPLM..VPTGprGPV.T..............QNPGM.PSVSSVM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19829 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CQMVHAAPGGGAQMQPQWRQPHQGPLMVPTGPRGPVTQNPGMPSVSSV
2) LPVNQNPLVPVASTAPQMNTFQNVSLHAAHDAAQKALEEAANQQQKNRFGQISTPPFSQSPVLPPGGKPSLSTVTTVSPPVLTQQQVPPQQPQQQTQVPQPGLPAVNQQPPQASQQQPNNQQTPPPTQPGMAAVPAPPPGAQQGVA
3) QQQRSMQPGQVQPNQNFLNRPPGPIPVTHGNVPQQLRAAATGNQQAPVTGAPPNQVQGQAQAPGGGMLRLQNPGANPQLRSLL
648
246
544
695
391
626










Molecular Recognition Features






MoRF SequenceStartStop




NANANA