<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19816

Description Mediator complex subunit 12 like
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLSVLAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQPADPNLEWTQISTRYLREQLAKISDFYHMASSSGDGPVPVPPEVEQAMKQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWPNQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSSSLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPAGENADEHYSKDHDVKMEIFSPMPGESCENANTSLGRRMSVNCEKLVKREKPRELIFPSNYNLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTETGGGDEGQKARKNKQETFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACFLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSTLKNDDFTMRGLRCDGNADDIWTASQNPKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSAELNNNSSNSGMSLFNPNSIGSADTSSSRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQKSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVQQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRRVIKYEEQHHLLLYHTHPKPKPRSYYLEPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKATTDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMHHPQSTLWGYNLVGQPQQPGFFLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
Length1810
PositionKinase
OrganismCallithrix jacchus (White-tufted-ear marmoset)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Platyrrhini> Cebidae> Callitrichinae> Callithrix> Callithrix.
Aromaticity0.07
Grand average of hydropathy-0.424
Instability index53.15
Isoelectric point7.61
Molecular weight203745.10
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19816
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.80|      23|     151|     753|     781|       1
---------------------------------------------------------------------------
  753-  776 (35.49/33.31)	CLILNpDQTAQVFEGLCGVVKHVV
  799-  821 (37.31/16.47)	CSHLR.SKFGDLFSSACSKVKQTI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.74|      19|      29|     971|     989|       2
---------------------------------------------------------------------------
  971-  989 (36.45/22.06)	LLAA..ACGDADAE....PGARMTC
  995- 1019 (27.29/14.63)	LFRApqACFLPQATgkpfPGIRSSC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     212.40|      51|     151|    1606|    1657|       3
---------------------------------------------------------------------------
 1606- 1657 (76.63/51.25)	QEPERKSAELSDQGKATTDEEKKTKGRKRKTKSSSRVDEyPQ.............SNI..YRVPPNY
 1680- 1732 (58.41/33.45)	Q.PQQPGFFLQNQS........LTPGGSRLDPAGSFV...PTntkqalsnmlqrrSGA..MMQPPSL
 1758- 1810 (77.37/47.06)	QAQTRPFQQFPRQGLQQTQQQQQTAALVRQLQKQLSSNQ.PQ.............QGVtpYGHPSHF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.05|      35|     153|    1046|    1101|       4
---------------------------------------------------------------------------
  874-  908 (63.53/31.15)	TLMN..VCM.GHQDAGRINDIANFSSELTACCTVLSSE
 1058- 1095 (55.52/45.77)	TLKNddFTMrGLRCDGNADDIWTASQNPKSCGKSISIE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      90.12|      32|     151|    1295|    1335|       6
---------------------------------------------------------------------------
 1295- 1313 (21.88/ 6.59)	...................G..............................................................................................................................................EELEKGQHLGSSSKKERD
 1322- 1334 ( 9.51/13.82)	LLSQQPFLSLVLT.......................................................................................................................................................................
 1477- 1494 (22.21/ 6.87)	....................clkgqdeqreglltslqnqvnqilsnwreeryqddikarqmmhealqlrlnlvggmfdtvqkstqwttdwallllqiitsgtvdmhtnnelfttvldmlgvlingtlasdlsnaspggseenkraymnlvkklkkelgdkrsESIDKVQQLLPLPKQTCD
 1495- 1531 (36.52/15.85)	VITCEPMGSLIDTkgnkiaG.............................................................................................................................................fDSIDKKQGLQVSTKQK..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.89|      21|      66|    1098|    1137|      12
---------------------------------------------------------------------------
  307-  333 (33.25/ 7.11)	CQESTAGvtisrvLHTLEVLDRHCFDR
 1111- 1131 (42.64/21.29)	CQQEWVG......EHCLKEPERLCTDK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.36|      18|     218|    1176|    1193|      16
---------------------------------------------------------------------------
 1176- 1193 (33.76/18.23)	QNLEQWTLRQSWLELQLM
 1395- 1412 (32.60/17.37)	QKSTQWTTDWALLLLQII
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19816 with Med12 domain of Kingdom Metazoa
Unable to open file!