<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19785

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMWTNVFKIGGLHQISWFQFLPHESDVNPLHDKSTKLEQKDAATLLVLSSHLQLQKEGFLSTWTNSFVGPWDPSQGLHNPDEKIKLWLFLPGRYSSVIESAQPAVSRLRVLASGIWLAPGDSEEVAVALSQALRNRIERALTGLSYMRFGDVFSKYHPFSQSEELFRRGQPVVEFIFAATEEAIFVHVLISAKHLWALSTRDMEKILNRSSNHSGDGLPVIVSPHGMRGRVSGYCPSDLVKQVYLSSSKVRTSNGIVGLPCNGSQVPGYQVGGQSCYVEVTLGFPTTGNDKVLPRNLNLKRNFPENHNTESSAMTSGGQKGSPDQSSVYERTFIYPVEAVLVPVLQTSFARSSLKRFWLQNWIGPSLIGSSFFMQCAGERDLEDGSWIEGNGICSEHDYHSSGNSNSSSISSLSSTSSDSDYPMAGGVGELEADADSLTCRQSGLSSSDQLPINGSKSGSKRSRTGIAESFGQAVTNDPMQDAYGSVEVNNSVITGVANDVGSQWDWDDDGRGVCVDIQALLSEFGGFGDLFENDVLPFGEPPGTAESQALMFSVPDSGDLGGSPCTAMMDVADQMLLPAGFPSFDNFGPPIGTKEESLSKNQELIKNAVPSGADNCTPASSAGEFVHLVKAEALMTFAPEYGAVENPTSEFSTSIFRRQYIPKSREVESANSSPESYVYCATPPSSSCLDRSDEKPGMGVNSKAHGRQDSSANLHPKNFYTIVERGKEQNEKRLIAVNNGIATHKVAAPSSFPGFNYANAVKTVQKKTNEATFETESFFMAMGTVIATEVECLVFQAYTCRIRHTLLSSCGHLPTGMSRLTGSSFLNQLHGDPSSVPANVFSKYEVKKKESIPVRIAGDIDGGLLEGPLNAPVGVWRSVGIPKGAKPTMSPSMEICPSLPSLPSEEGMLSYGQRQPLQEFLDGLALLVQQATSFVDVALDADCGDGPYGWLALQEQQRRGFSCGPSMVHAGCGGSLASCHSLDIAGVDLVDPLFADVHASAVIGLLQSDIKTALRSSFGTLDGPLSVTDWCKGRSQSCDAGTMGDGFSTELTGGECRDSSGTVTLPAGESLSPSQSSAVGSLYLKDGARVDETSQWRSNQDTSASETEQQLGFRLRPTLFVLPLPAILVGYQDDWLKTSASSLQLWEKAPLEPYALQKHMTYCVVCPDIDPLTTAAADFFQQLDTVYETCKLGTHSPQSLGNQMEIDSGKWSSSGFILLDCPQSMKIESSTASLVGSISDYFLSLSNGWDLTSYLKSLSKVLKALKVGSCFTSNPKEGNGGPCMVIYVVCPFPEPIAVLQTVIESSVAVGSVILSADKERRSIMHSQVGKALSCSASVDEASISNVLTLPGFCIPKLVLQIVTVDAIFRVASPALNELVILKEIAFTVYNKARRISRGSSTDVVQSSSLSSRSHSTLMQMNSPISGMWKDCIGPRITGSSLPREGELDPSLRHSSWENTWPSSRGGGFGCDPHRTGDFFLRDETRYMFEPLFILAEPGSVERGVSPSVFANLASESSKSDDCSSGSFAQSSVSSGSVDAGPSSQPDGSEQDGFGSGHQKMLPSLHCCYGWTEDWRWLICIWTDSRGELLDSHVFPFGGISSRQDTKGLQSLFVQMLQQGCQILQACSSTDTGVVKPRDFVISRIGCFYELECQEWQKALYSVGGSEVKKWPLQLRRSVPDGMLAGSNGNSLQEQEMSIIQERALPSSPNPLYSSHSKASGFIKGGLGQTSARKQIISGPPVVDHTRGLLQWVQSISFVSISVDHSTHLVFQADSASSGGTQGSSTANPSGYLEGFTPVKSLGTTPASYILIPSPSMRFLPPTPLQLPTCLTAESPPLAHLLHSKGSAIPLSTGFAVSKAVPSMRKDSRSNSKEEWPSVISVSLVDHYGGSNITQEKITRGGVKQGGRGLSSEARDFEIETHLILESLAAELHALSWMTVSPAYLERRTALPFHCDMVLRFRRLLHFADKELSRRTEKTQV
Length1980
PositionKinase
OrganismActinidia chinensis var. chinensis
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> Ericales> Actinidiaceae> Actinidia.
Aromaticity0.08
Grand average of hydropathy-0.218
Instability index53.21
Isoelectric point5.47
Molecular weight213703.95
Publications
PubMed=29661190

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19785
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     388.47|      97|     122|    1396|    1493|       1
---------------------------------------------------------------------------
 1396- 1493 (170.78/83.35)	SRG.SSTD..VVQSSSLSSRSHSTLMQMNSPIS...GMWKDCIGPRITGSS..LPREGELDP.SLRHSSWE.NTWPSSRGGGFGCDPHRTGDFFLRDETRYMfEPLFI
 1514- 1613 (149.15/68.76)	SES.SKSD..DCSSGSFAQSSVSSGSVDAGPSSqpdGSEQDGFG...SGHQkmLPSLHCCYG.WTEDWRWLiCIWTDSRGELLDSHVFPFGGISSRQDTKGL.QSLFV
 1623- 1688 (68.54/27.09)	LQAcSSTDtgVVKPRDFVISRIGCFYELECQ......EWQKAL.YSVGGSE..VKKW....PlQLRRSVPD.GMLAGSNG............................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     210.35|      69|     122|     619|     740|       2
---------------------------------------------------------------------------
  422-  490 (114.33/42.19)	PMAGGVGELEADADS.LTC....RQSGLSSSDQLP...INGSKSGSKRSRTGI.AESFGQAVTNDPMQDAYGSVEVNN
  662-  739 (96.02/114.34)	PKSREVESANSSPESyVYCatppSSSCLDRSDEKPgmgVNSKAHGRQDSSANLhPKNFYTIVERGKEQNEKRLIAVNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.07|      10|     123|    1162|    1172|       3
---------------------------------------------------------------------------
 1162- 1172 (17.32/17.21)	YcVVCPDIDPL
 1287- 1296 (22.75/14.90)	Y.VVCPFPEPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.43|      35|     125|     986|    1025|       6
---------------------------------------------------------------------------
  181-  219 (45.80/26.96)	EAIFVHVLISAkhLWALSTRDMEKILnRSSNHSGDGlPV
  991- 1025 (58.63/53.21)	DPLFADVHASA..VIGLLQSDIKTAL.RSSFGTLDG.PL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.92|      26|     681|     140|     171|      12
---------------------------------------------------------------------------
  140-  171 (40.11/39.44)	LTGLSYMR..FGD.......VFSKYHpFSQSEELfrrgqPV
  820-  854 (36.81/19.76)	LTGSSFLNqlHGDpssvpanVFSKYE.VKKKESI.....PV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     140.05|      43|     636|    1189|    1233|      14
---------------------------------------------------------------------------
 1189- 1233 (69.68/47.36)	TCkLGTHSPqSLGNQME.IDSGKWSSSGFILLDCPQSMKIESSTAS
 1828- 1871 (70.37/39.57)	TC.LTAESP.PLAHLLHsKGSAIPLSTGFAVSKAVPSMRKDSRSNS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19785 with Med13 domain of Kingdom Viridiplantae
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