<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19759

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAELGQQTVEFSTLVGRAAEESFVSLKELVEQSRSSEQSDSEKKINLLKFLVKTQQRMLRLNVLAKWCQQVPLIHYSQQLASTLSNHDMCFTQAADSLFFMHEGLQQARAPIYDVPSAIEVLLTGSYERLPKCIEEVGIQSTLTEDQQKPALKKLDTLVRSKLLEVTLPKEISVVKVSDGTAMLRVDGEFKVLVTLGYRGHLTMWRILHLELLIGERSGLAKLEELRRHALGDDLERRMAAAENPFIILYSVLHELCVALVMDTVIRQVQSLRQGRWKDAIRFELVTDGSLGQSGNAGSTQMSQDGETDSAGLRTPGLKILYWLDFDKTSGTSDSGSCPFIKIEPGPDLQIKCLHSSFVIDPLTGKEAEFSLDQSCIDVEKLLLRAICCNRYTRLFEIYKELTKNGQIFRAAGDVLLQCRADEPVVDYKKKDNKSNAKECEGQEVLCVRAYGSSYFILGINIRNGRFLLHSSRNILTPSALIDCEEALNLGSMTAADVFTSLRSKSILHLFACIGRFIGLEVYEHGFAAVKVPKNILNGPSSLLMGFPDSGSSYFLLMQLDKDFKPLFKLLETQLDPSIKAQSFGDLHNFRVKDIDIGQIQLHEDELNLSLLDCRKLLSLSPNAASGNQTSEQGLLSELSLEGSMLSSGSLPSSFPSIVDEVFDLERGSSFNISAASNFGSVPMSFQNIKAGTSSPKWEGGTQIAHVSSVPKISSGSPHYTGSIYSSSNLKGIMQTIPVSSPSTGPGRIATSKKLSASKSDQDLASLRSLHSSDSCSTMDEDQLTAAGNRSSRLLSPPRLTGPRVSSPIAKPSGLINSTTGTVDGSFKVSGSSSWATASVSQGPDFVVTKHDKRLRKRSVSDMLNLIPSLFEDHSDLRKRRKVNELGFRQQTSPQPLFSPDMIGKTEGYSYASLIAEANKGNAPSSLYVSALLHVVRHCSLCIKHARLTSQMDALDIPYVEEVGLRNASSNLWFRLPFARGDTWQHICLRLGRPGSMYWDVKINDQHFRDLWELQKGSNATPWGSGVRIANTSDVDSHIRYDPEGVVLSYHSVEADGIKKLVADIQRLSNARMFAHGMRKLLGVKPDEKLEEGSSNSDDKAPPGAKGAMEIAEKFSEHMRRAFRIEAVGLMSLWFSFGSGVLARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFINGAEVASLLDCIRLTAGPLHALAAATRPARAGPASGVPGVATPIPSFGKQSGYLQPQGHLQSSSTTNVSQTATASGGNPVTSSTAGSLGNHNLHGAVMLVAAGRGGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKYFAVDMRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQELNGLEPNFSGGQQTVGMTNANSPNPSSALQLSTSGGNRVNLSNPGGMPRSGNQVTGLNRMGNTLSASSNLSVVSAGLPVRRSPGAGVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKDNEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHHSQQQQQQQQQNSTIAQEELTQSEIGEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLAQAQGGDTAPAQKPRIELCLENHAGLNADGSSESLSSSRSNIHYDRPNNSVDFALTVVLDPTHIPLINAAGGAAWLPYCVSVRLRYSFGESPSVSFLGMEGSHGGRACWLRLDDWNMCKQRVSRTVEAIAVSAGDINQGRLRIVADSVQRTLHTGLQGLRDGSGVRTSSGAS
Length1800
PositionTail
OrganismActinidia chinensis var. chinensis
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> Ericales> Actinidiaceae> Actinidia.
Aromaticity0.07
Grand average of hydropathy-0.177
Instability index46.71
Isoelectric point7.98
Molecular weight195784.58
Publications
PubMed=29661190

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP19759
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     755.39|     193|     298|     619|     811|       1
---------------------------------------------------------------------------
  619-  717 (121.24/61.63)	.......................................................................................................................SLSPNAASGNQTSE...Q.GLL.....SELSLEG.SM.LSSGSLPSSFPSIVDEVFDLERGSSFNIS.......AASNFGSVPMSFQNI..KAG.TSSPKWEGGTQIA.HVSSVPKISSGS
  718-  811 (111.98/56.28)	PHYTG.SIYSSSNLKGIMQTIPVSSPSTGPGRIAT..S.KKLSASKSDQDLASL.RSL..HSSDSCSTMDEDQLTAAGNRSSRLLSPPRLTGPRVSSPIAK...........................................................................................................................................
  820- 1018 (234.98/127.32)	...TG.TVDGSFKVSG.SSSWATASVSQGPDFVVTkhD.KRLR.KRSVSDMLNLiPSLfeDHSDLRKRRKVNEL...GFRQQ..TSPQPLFSPDM...IGK...........tegysyaSLIAEANKGNAPSSlyvS.ALLhvvrhCSLCIKH.AR.LTSQMDALDIP.YVEEV.GL.RNASSNLW.......FRLPFARGD.TWQHIclRLGrPGSMYWDVKINDQ.HFRDLWELQKGS
 1022- 1229 (229.57/124.20)	PWGSGvRIANTSDVDSHIRYDPEGVVLSYHSVEAD..GiKKLVADI..QRLSNA.RMF.aHGMRKLLGVKPDEKLEEGSSNSDDKAPP...GAKGAMEIAEkfsehmrrafrieavglmSLWFSFGSG.VLAR...F.VVE.....WESGKEGcTMhVSPDQLWPHTKFLEDFINGAEVAS.....lldcirlTAGPLHALAAATRPA..RAG.PAS....GVPGVAtPIPSFGK.QSGY
 1381- 1451 (57.61/24.88)	.........................................................................................................................SPNPSSALQLST...SgGNR.....VNLSNPG.GM.PRSG..........NQVTGLNRMGN.TLS.......ASSNL.SVVSAGLPV..RRS.PGA....GVP..A.HVR.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.25|      21|     297|     207|     231|       3
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  207-  231 (30.74/24.18)	ILHLELLIGERSGLakleELRRHAL
  507-  527 (40.52/22.69)	ILHLFACIGRFIGL....EVYEHGF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     164.99|      53|     129|     431|     488|       4
---------------------------------------------------------------------------
  431-  488 (84.31/75.47)	KDNKSNAKECEGQEVLCVRA..YGS..SYFILGINIrnGRFLLHSSRNILtpsALIDCEEAL
  562-  618 (80.68/56.57)	KDFKPLFKLLETQLDPSIKAqsFGDlhNFRVKDIDI..GQIQLHEDELNL...SLLDCRKLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     123.01|      42|    1331|     152|     198|       5
---------------------------------------------------------------------------
  152-  198 (61.28/48.99)	LKKLDTLvrskLLEVTLP...KEI..SVVKVSDGtAMLRVDGEFKVLVTL..GY
 1485- 1533 (61.73/36.40)	LKYLGVL....WLFAQLPdllKEIlgSILKDNEG.ALLNLDQEQPALRFFvgGY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.87|      14|     263|    1461|    1474|       6
---------------------------------------------------------------------------
 1461- 1474 (30.27/18.11)	LGDDGGYGG..GWVPL
 1725- 1740 (25.60/13.95)	LGMEGSHGGraCWLRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.89|      11|     214|     331|     341|       8
---------------------------------------------------------------------------
  331-  341 (23.11/11.55)	GTSDSGSCPFI
  546-  556 (22.78/11.28)	GFPDSGSSYFL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19759 with Med14 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GHLQSSSTTNVSQTATASGGNPVTSSTAGS
2) GLEPNFSGGQQTVGMTNANSPNPSSALQLSTSGGNRVNLSNPGGMPRSGNQVTGLNRM
3) SCSTMDEDQLTAAGNRSSRLLSPPRLTGPRVSSPIAKPSGLIN
1234
1362
775
1263
1419
817










Molecular Recognition Features






MoRF SequenceStartStop




NANANA