<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19749

Description Serine/threonine-protein kinase isoform 1
SequenceMAVVSRMPLTLQQINPITYHNFKNPRMMASRGEISEEPPVQVVEDKVYVAVGKEYSESKSTLTWALHNSGGRKICILHVHEPAQRIPFMGTKIQASRLEEQQVKAYRETEKQDMNKLLREYGMLCKQAGVHAELLHIEMESIEKGILELISQHSIRKLVMGAAADKHYSKKMLEPKSKKAIHVRLQAPISCHIWFICRGNLVHTREGRLEGVSMEVASLIQQASPKTEIGKSNQWRSRSTNQVQNDQLTLFTPSPQHRRVRSDVRGTEASTSSPDSSREGTPCSTERNFSEWDRISGWSPSLNSLFSPFSAGDMADDSALASAARAEDGLESRAMHHLKDDCQLTSPSSVLQERVMKDELYDKLKQAMEEVENSRREAFEESVRRRKAEKEAIDAFRRAKTAESLYAEEMRQRKETEEALAKGKEELENMKQKVDEVMEELGISLEQNSSLESQIAHTEKTIQELEQKMFSAVELMQKYKTERDELQVEHDNALTVSEELRKKYSEKSSNSLMPQIFSEFSFSEIERATNNFDPALKIGEGGYGIIYKCLLRNTQVAIKMLHSHSLQGPLEFQQEVNILSKLRHPNLVTLVGACPETWTLVYEYLPNGSLEDRLSCKDNTPPLSWQTRLRIAVELCSVLIFLHNSTPHNIVVHGDLKPANILLDENYVCKLSDFGICRAISQNELSSNNTTLCCRTDPKGTFAYMDPEFHATGELTRKSDTYSFGIILLRLLTGRSVFGLPKEVQCALDKGTLKNLLDPTAGDWPFVQAKQLAHLAMRCCEMNRRRRPDLASDVWRMLEPMSVLCGASSFRLSSDERCQIPPYFICPIFQKIMQDPHVAADGFSYELEAMRRWLDSGHNTSPKTNLKLTHCNLVPNHTLRSAIQEWLHQP
Length890
PositionTail
OrganismActinidia chinensis var. chinensis
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> Ericales> Actinidiaceae> Actinidia.
Aromaticity0.06
Grand average of hydropathy-0.529
Instability index52.61
Isoelectric point6.52
Molecular weight101198.19
Publications
PubMed=29661190

Function

Annotated function Functions as an E3 ubiquitin ligase. 
ECO:0000256	ARBA:ARBA00003861
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein kinase activity	GO:0004672	IEA:InterPro
ubiquitin-protein transferase activity	GO:0004842	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19749
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     131.52|      36|      49|     672|     707|       1
---------------------------------------------------------------------------
  634-  665 (19.25/ 7.38)	.................ELCSvliflHNSTphnIVVHGDLKPAN.ILLDE
  672-  707 (67.72/44.16)	SD...FGI..CRAISQNELSS.....NNTT...LCCRTDPKGTF.AYMDP
  719-  759 (44.55/26.57)	SDtysFGIilLRLLTGRSVFG.....LPKE...VQCALD.KGTLkNLLDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.46|      11|      88|     408|     418|       2
---------------------------------------------------------------------------
  381-  391 (16.99/ 9.41)	ESVRRRKAEKE
  408-  418 (19.47/11.80)	EEMRQRKETEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     123.51|      42|      50|     425|     471|       3
---------------------------------------------------------------------------
  425-  467 (64.90/54.87)	EELENMKQKVDE..........VMEELGISLEQNSS..LESQIaHTEKTIQELEQ
  474-  527 (58.61/34.42)	ELMQKYKTERDElqvehdnaltVSEELRKKYSEKSSnsLMPQI.FSEFSFSEIER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.02|      27|     624|     171|     197|       6
---------------------------------------------------------------------------
  171-  197 (53.73/32.97)	KMLEPKS..KKAIHVRLQAPISCHI..WFIC
  796-  826 (44.29/26.00)	RMLEPMSvlCGASSFRLSSDERCQIppYFIC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.49|      11|      19|     330|     340|       8
---------------------------------------------------------------------------
  330-  340 (20.13/13.30)	LESRAM.HHLKD
  351-  362 (15.36/ 8.37)	LQERVMkDELYD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19749 with Med32 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DDSALASAARAEDGLESRAMHHLKDDCQLTSPSSVL
2) SLYAEEMRQRKETEEALAKGKEELENMKQK
3) TEIGKSNQWRSRSTNQVQNDQLTLFTPSPQHRRVRSDVRGTEASTSSPDSSREGTPCSTE
316
404
227
351
433
286










Molecular Recognition Features






MoRF SequenceStartStop




NANANA