<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19736

Description Mediator of RNA polymerase II transcription subunit like
SequenceMQRYHAAGCTSAVNNSAVGGTSARDTSRVDPSSLPTNFSLNQRRLPQLTSYKLKCDKEPLNSRLGPPDFHPQTPNCPEETLTREYVQSGYRETVEGLEETREISLSQVQTFTKPVILKCKEAIRKCHRAINESRAQKRKAGQVYGVPLSGTLLTKPGVFPEQRPCGEDFRRKWIEGLSQPHKRLRSLSDHVPHGYRKKSLFEVLIRNNVPLLRATWFIKVTYLNQVRPVSASIASGVPDKTQFARTEQWTKDVIDYLQCLLDEFVSRNASHSNTHVRERSPHMVYVGSLQHKSDTASAVLDGDEPSIHFKWWYVVRILQWHHAEGLLLPSLIIDWVLNQLQEKDLLGTLQLLLPILYGVIESVVLSQTYVRTVVGLAVRFIQEPSPGGSHLVDNSRRAYTTSAMVEMLRYMILAVPDTFVALDCFPLPPYVVSHVVNDGNFLSKVSDGTAKINSGSVEAGVLLKEKVIEPQHQSFSIDCVVSSIQKCANNLAMAARPGYPGRSVVKAVQELDKALVQGDVRMAYSVLFNDLCEGAVDEGWVAEVSPCLRSSLKWIGTVSLSFVCPVFVLCEWATCDFRDFRNAPPCGMKFTGGKDFSQVYLAIRLLKLKIKDMQSSLRCKNDGTRGVNSLAKGPELSNIFESPGPLHDIIVCWLDQHEVQNGEGFKRLQLLIVELTRSGIFYPQAYVRQLIVSGIMDGNGLPVDIDRRKRHYKILKQLPGSYIRDALEEAQITEMPVLLEATNVYSNERRLLLNGLIDHHKNPNSADISSKKQKHHLTSGGDGASPHSVDQWRTLQPSSRLPGKSSNRTADIEELKTAISVLLQLPNSSCTYTDIVIDESQGSVKSLGGSTSDITDLGEGTPGCEECRRAKRQKLSDERSSYVQGNSANSLDDEESWWVRKGLKPMEALKTDPPLKPAKQSTRGRQKIVRKTQSLAQLGAARIEGSQGASTSHICDSRVSCPHHGTGFDGETPKSMRGIRTPHSGDIVSIGKMLKQLRFVEKRFITIWLVTVVRQLVEENEKAAAKVGQYGRPFPSVDDKTSLRWKLGEDELSAILFLIDVSNDLVSAARFLLWLLPKVLSSPNSTIHGGRNVLMLPRNVGTHACEVGEAFLLSSIRRYENILVATELLPETLSAMMHRATTILASNGRVSGSVALVYARYLLKKYASVASVVEWEKNFKATCDKRLLPELESGRSLDGELVLPLGVPAGVEDLDDFLRQKISGGRVSRVGLSMREMVHRQVEEAVQYFYGKERKLFAAGTIKGPTLEKGDDGYQMAQQIVIGLMDCMRQTGGAAQEGDPSLVSSAVSAIFNSIGPVVAKLPDLTASGNHPNFPSSAGSLTFARRILRSHITCLYLLKEALGERQSRVFEIALATEASSALAQAFAPGKAPRGQFQLSPEAHDSNANSSNEHMNSSAKTGRAAKIAAAVSALVIGAILHGVASLERMVTVFKLKEGLDVIQFLRTTRSNSNGNARSVGAFKADNVVEISAHWFRVLVGNCRTVSDGLIMDLLGEASVVALSRMQRTLPLSLIFPPAYSIFAFVIWRPYIFNTSIVIREDIHQLYQCLVFAIGDAIKHLPFRDVCLRDTREFYDLVVADATDSEFAAMLELNGAEMHMKAMAFVPLRARLFLNAIIDCKMPQSMSTQDDGNRVGESGVRYAENETKLLDKLVHVLDTLQPAKFHWQWVELRLLLNEQALIEKLDSHDTSLVEAIRSSSPNPDKGAASENENNFIEIILTRLLVRPDAAPLFSEVIHLFGRSLEDSMLLQAKWFLGGPDVLFGRKSIRQRLINIAESKGLSTKAHFRKPWGWCYSNSDLLSSKGDVRKFETSSLEEGEVVEEGAEVKRLGSGSTQVLDVESSNICQQYITERALIELVLSCIDQSSDDSRSTFASDLIKQMTNIEQQINAVTRGASKQGGAVNSGSEGTGTKSNNRKGMRGGSPGLARRSTVTADIVPPSPAALRASMSLRLQFLIRLLPIICADGEPSARNMRHMLASVVLRLLGSRVVHEVVEQSLFPMLSSSLKTDVDLSTEAFAASAVDLSGESLFNRLLLVLHGLLSSSRPRWLKSKKDFSVFDREVAESLQNDLDRMHLPDSIRWRIQAAMPTLFPSFRWHISCQPPSVSPAALASLQPSISVSGSHPGNSNLPQRNPGSSTRTATSLAGKTKPSTLQQDIDMEIDPWTLLEDGAGSGPSSTSTSGIGGSDNANLRASSLLKGAVRVRRTDLTYIGVVDDDS
Length2236
PositionKinase
OrganismActinidia chinensis var. chinensis
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> Ericales> Actinidiaceae> Actinidia.
Aromaticity0.06
Grand average of hydropathy-0.209
Instability index46.30
Isoelectric point8.60
Molecular weight246338.56
Publications
PubMed=29661190

Function

Annotated function 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of development, heterochronic	GO:0040034	IEA:EnsemblPlants
regulation of radial pattern formation	GO:0090213	IEA:EnsemblPlants
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19736
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.69|      27|      87|      59|      87|       1
---------------------------------------------------------------------------
   59-   87 (45.05/34.00)	PLNSRL..GPPDFHPQTPnCPEEtLTREYVQ
  147-  175 (48.64/27.55)	PLSGTLltKPGVFPEQRP.CGED.FRRKWIE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     456.69|     177|     899|     689|    1190|       4
---------------------------------------------------------------------------
  920-  988 (49.33/551.38)	QSTRGRQKIVRKTQSLAQLGAAriegSQGASTShicDSRVSCPHHGTGFDGETPKSMRG......IRTPHSGDIV....................................................................................................................................................................................................................
 1070- 1190 (153.50/97.37)	...........................................................................sigkmlkqlrfvekrfitiwlvtvvrqlveenekaaakvgqygrpfpsvddktslrwklgedelsailflidvsndlvsaaRFLLWLLPKVLSSPNSTIHGGRNVL..MLPRNVGTHAC.EVGEA..F.LLSSIRRyENILVATELLPET...LSAMMHRATTILASNGRVSGSvalvYARYL.LKKYASVASvVEWEKNFKATCDKRLLPE
 1888- 2095 (253.87/ 0.00)	RSTFASDLIKQMTNIEQQINAV....TRGASKQ...GGAVNSGSEGTGTKSNNRKGMRGgspglaRRSTVTADIV..................................................................ppspaalrasmslrlQFLIRLLPIICADGEPSARNMRHMLasVVLRLLGSRVVhEVVEQslFpMLSSSLK.TDVDLSTEAFAASavdLSGESLFNRLLLVLHGLLSSS....RPRWLkSKKDFSVFD.REVAESLQNDLDRMHLPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     177.57|      56|     750|    1347|    1404|       6
---------------------------------------------------------------------------
 1347- 1404 (83.97/67.80)	LRSHITCL..YLLKEALGERQSRVfEIALATEASSALAQAfAPGKAPRGQFQLSPEAHDS
 2112- 2169 (93.60/64.72)	FRWHISCQppSVSPAALASLQPSI.SVSGSHPGNSNLPQR.NPGSSTRTATSLAGKTKPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     154.39|      49|     365|     251|     329|       7
---------------------------------------------------------------------------
  251-  301 (79.31/58.45)	KDVIDYLQCLLDEF..VSRNASHSNTHVRERSPHMVYVgsLQHKSDTASAVLD
  343-  393 (75.07/57.35)	KDLLGTLQLLLPILygVIESVVLSQTYVRTVVGLAVRF..IQEPSPGGSHLVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     188.48|      65|     899|     726|     816|      13
---------------------------------------------------------------------------
  726-  801 (96.28/81.48)	ALEEAQITeMPVLLEATNVYSNerrlLLNGlidhhkNPNSADI.SSKKQK..HHLTSGGDGASPHSVDQ....W..RTLQPSSRL
  836-  909 (92.19/69.71)	VIDESQGS.VKSLGGSTSDITD....LGEG......TPGCEECrRAKRQKlsDERSSYVQGNSANSLDDeeswWvrKGLKPMEAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.88|      19|     669|     626|     645|      15
---------------------------------------------------------------------------
  626-  645 (30.63/25.66)	GVNSLAKGpELSNIFESPGP
 1298- 1316 (34.25/22.53)	GDPSLVSS.AVSAIFNSIGP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19736 with Med12 domain of Kingdom Viridiplantae
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