<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19724

Description Mediator of RNA polymerase II transcription subunit 4
SequenceMLQNVPHQIVPSPARLGLPNPNSPSVQNPTAPKFSSQLPQSHVPNQQSTLSTFTTTSSTLLPLLPPLSRAQSLLLQMASLASRLFDVSPNRSHWISAFRGSLPTFLSSQTQTLAPTPPDASPSSTKEIISLFTSLQTQLFEAVAELQEILDLQDAKQKLTREIRSKDTAMLSFANKLKETERVLDILVDDYSDYRRLKRSKSDDNADDSCTTTIATQLNLSDILSYAHRISYTTFAPPEFGAGQAPLRGALPPAPQEEQLRASQLYAFAELDVGLPKSVESKEKTMEPFIEAPPAQPAELNPLANLTAIQGLLPPNIVVPSGWKPGMPVELPSDLPIVPPPGWKPGDPVPLPPLDVLPVPGRAEEQPPRPIPAPGMPKAPEPMQVRHVQLDIDDDSSDYSSDMGSSDDED
Length410
PositionMiddle
OrganismActinidia chinensis var. chinensis
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> Ericales> Actinidiaceae> Actinidia.
Aromaticity0.05
Grand average of hydropathy-0.391
Instability index75.24
Isoelectric point4.78
Molecular weight44566.89
Publications
PubMed=29661190

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364141
GO - Cellular Component
mediator complex	GO:0016592	IEA:EnsemblPlants
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP19724
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.38|      17|      19|     314|     332|       1
---------------------------------------------------------------------------
  314-  332 (34.81/19.53)	PpnIVVPSGWKPGMPVELP
  336-  352 (40.57/17.57)	P..IVPPPGWKPGDPVPLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.54|      29|      50|      34|      66|       2
---------------------------------------------------------------------------
   18-   35 (31.51/ 7.90)	LPN...PNSPSVQN..........PTAPKFS
   38-   68 (43.95/23.73)	LPQshVPNQQSTLSTFTTTSSTLLPLLPPLS
   95-  118 (26.08/ 6.70)	.....ISAFRGSLPTFLSSQTQTLAPTPP..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.99|      29|      32|     125|     154|       3
---------------------------------------------------------------------------
  125-  154 (41.61/30.11)	TKEIISLFTSLQTqLFEAVAELQEILD.LQD
  160-  189 (42.38/26.02)	TREIRSKDTAMLS.FANKLKETERVLDiLVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.28|      12|      53|     236|     247|       5
---------------------------------------------------------------------------
  236-  247 (23.44/10.02)	APPEFGAGQAPL
  292-  303 (21.83/ 8.86)	APPAQPAELNPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.52|      16|     123|     249|     265|       6
---------------------------------------------------------------------------
  249-  265 (26.67/14.95)	GaLPPAPQEEQLRASQL
  375-  390 (30.85/13.80)	G.MPKAPEPMQVRHVQL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19724 with Med4 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PVELPSDLPIVPPPGWKPGDPVPLPPLDVLPVPGRAEEQPPRPIPAPGMPKAPEPMQVRHVQLDIDDDSSDYSSDMGSSDDED
2) QIVPSPARLGLPNPNSPSVQNPTAPKFSSQLPQSHVPNQQSTLS
328
8
410
51










Molecular Recognition Features






MoRF SequenceStartStop




1) PRPIPAPGMPKAPEPMQVRHVQLDI
368
392