<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19723

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDQPVNGPLVNGNSHSHTPFDDIPNGLHEPTIEELERELPAVHDGQIPLGDLVSRTVQAIYAELTELAETMPSMSDPQRKRVLADWVVKTKKQVVKLYAVVKWARDAGVVQKAMNVTAFLMDQNRQFEDAIHGLTYAKESLDPARLRNHDLLTSLDVLTTGSYRRLPTGIKKSVVPPTPLTDKEVSKALSDMEDVIRYRLRMNEIIPCEMANYRIADGRVHFVVPKLFEASMCLKGAQKDEGWFFVDIEFLFTVGGDPTGMQDFPRHPTGVLRRHIADEADNRLAFYLPPPPNQIPLPESETPPRPQLPEGVVDAPLVRLFNFLQMMSMSYQLEILWYQAERLRSLGWADYLAVDMSNDRKTLTISYWIRKQLQHIPGRPPPPRTKLPPLGGTLTISIIPSQPSPPQSRLSATSLASVALPGGHAPHRKPKDRVLMELQERAKLAGKGRPSDEVEGMKFDVKWEPQRGALGVVINPEDVKLTKAELAIQSDDLDIEALLKKVISRHTKAILNVFQLQLQRGSYRNAFGAPGEVTLVTDEGSLALRAHLCADEVVVITIEPRTGRLSLRDTGDLAAAGRGPKFTIISDRINENPVLLPDALVRLRFNTILDLAEQKANYLGLQSFRGRNFRREEMAKLGPAARATLYIQLSNFPSHYLVLVITDEDFRYALISVKVHADTMYAEMTMEDIGWLDVQRIHGQGVVVKPRPGMETVEVGTGQKRKRGLFDEGKRGMEHEPPSSSFRLETQVLRELYAYCCARVAYTKVEQQLKSRGIPYQHFNPSVGSLPELAHIHSSLARSIPALCVQSSDILSGAPAAEAAMPNIRVIPLNWWSDQKAQVVTCVKLKYVQQPVGKRAGGAVIRPSKRIIYDAKEAVVTFLSEDVDKCVDEFLEEWARVSKMVVIAREVAQMATEKRWKDVRLLSFDLQTVEFAYVGDYTVSITCTDQLSPTGGTYELSFSRATEESAMDTREESQDINQILAEYNPHEDVEPFIRHILRQGKLSQSLHKLVALLRDTLPIVAELEYIRVSAGRAGESIDTFAKTAGWFRILFGDLRHALDFRLLSGNRVFILDASNSLFQPEDRPTAAPTRDNSVVLQPIPNFRSIVQAACKDVVAQHIGRKIAPVDIGIMCDPSTVRAVTRALYERVRRCLKETGSISYGSVVA
Length1164
PositionTail
OrganismPhlebia centrifuga
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Polyporales> Meruliaceae> Phlebia.
Aromaticity0.07
Grand average of hydropathy-0.252
Instability index45.34
Isoelectric point7.15
Molecular weight130232.04
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19723
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.20|      21|      22|     376|     397|       1
---------------------------------------------------------------------------
  358-  387 (33.82/19.36)	NDRKTLTISywirkqlqhIPGRPPPPRTKL
  389-  410 (35.37/14.93)	PLGGTLTIS........iIPSQPSPPQSRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.99|      20|      22|     521|     542|       2
---------------------------------------------------------------------------
  522-  542 (30.10/27.59)	SYRNAFGApGEVTLVTDE...GSL
  543-  565 (28.89/14.21)	ALRAHLCA.DEVVVITIEprtGRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     164.15|      53|     202|     770|     826|       3
---------------------------------------------------------------------------
  770-  826 (83.58/60.83)	KSRGIP..YQHFNPSVGSLPELAHI..HSSLARSIPALCVQSSDILsgaPAAeAAMPNIRV
  972- 1028 (80.57/47.58)	ESQDINqiLAEYNPHEDVEPFIRHIlrQGKLSQSLHKLVALLRDTL...PIV.AELEYIRV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.61|      17|      22|      23|      44|       4
---------------------------------------------------------------------------
   23-   39 (30.44/26.36)	IPNG.LHEPTIEELEREL
   47-   64 (24.17/ 7.64)	IPLGdLVSRTVQAIYAEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.16|      10|      22|     425|     434|       5
---------------------------------------------------------------------------
  425-  434 (19.16/ 9.88)	APHRKPKDRV
  445-  454 (17.99/ 8.82)	AGKGRPSDEV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.21|      12|      22|     700|     711|       6
---------------------------------------------------------------------------
  700-  711 (22.26/13.98)	QGVVVKPRPGME
  723-  734 (21.95/13.68)	RGLFDEGKRGME
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     268.73|      84|      90|     167|     255|       7
---------------------------------------------------------------------------
  167-  255 (137.80/108.15)	PTGIKKSVVPPTPLTDKEVSkalSDMEDVIRYRL..RMNEI.IPCEMANYR..IADGRVHFVVPKLFE.ASMCLKGAQKDEGWFfvDIEFLFTVG
  258-  347 (130.93/89.24)	PTGMQDFPRHPTGVLRRHIA...DEADNRLAFYLppPPNQIpLPESETPPRpqLPEGVVDAPLVRLFNfLQMMSMSYQLEILWY..QAERLRSLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     184.44|      59|     788|     102|     163|       9
---------------------------------------------------------------------------
  102-  163 (91.77/83.07)	KWARDAGVVQKAMNVTAflMDQNRQFEDaIHGLTYAKESLDPARLRNHDL.LTSLDVL..TTGSY
  893-  954 (92.67/71.27)	EWARVSKMVVIAREVAQ..MATEKRWKD.VRLLSFDLQTVEFAYVGDYTVsITCTDQLspTGGTY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19723 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MDQPVNGPLVNGNSHSHTPFDDIPNGLHEPTIEELERELP
1
40










Molecular Recognition Features






MoRF SequenceStartStop




NANANA