<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19694

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMAAKQQNQPLDSTGCAALAEQPPRISLASPLLASAIDLPSQPLIVYSVYTPISGQPGVDPLYALEQARRRIVEKNSSRTVVDSLLPSVHLSRDSSVLYVFAFSSTHKPSASQTALQGAQFDDLILAESSQFSLTGLYPCSDPCSTQRTPCTTCLNPASPLATSSAPSSSQPPPAPWTSSACLLPRKPLRGPYSRFTQAVRDRLIDDVTRASKTARASATERAAVRLKGGFLLSSPASSSASEWGTGWDHYTLQRTLVHCELQIQLCSSRLLIHPILRPTHYLPLSNILPAPAGTPITLLPLGVPAYYLNIYSGPVGGLASQFDSALSGLGAGDWKNPGHFSQAVPSAIKDGMPSYAIVWLSVQNNQGEAKGIPLIWPARLCIALSTTAPHVRPPLEYIPSLPTQLQASPPALTAQDHPVKLVRRSLTPATVLSGAPSPFSEQTAPTISQRATSMPVSSEGGLLVPKPVRPVLSPRSPTSDSLRAFRALTLTNTDVGVIAQEVSSFVDAIMKDRERERERLRREREGSSSKLGANSIKPEKTEEPSQPSLLPSTEMHVDESVPLKAEDTVDAVHDYAFPTPEQRTSPADPYRTGPTTLDVLLPAAGITSASDVRQPSAVEPIKKEEAADGNDTTSESAVTPTSDPISYDSFPVFESNWGQHAGEFLTMDMGIDNFGVGFSVGMTGLGEMETNFGGFTDDDFNFFDAPAPNSRSFAATGSGLTPAAGPAPFGIPPPTLSTGMIPSGLGPPSGLSQAHPLPWMTQVLGEAFTPHSIDTPVSAMLPPPELLPATPALTPPSQSAPVTPVVMLLDRESITYRRNGSIGNLSPSAFDPIPFARSHKMADGKYLMGKFALPSPPDEEDRTQPIPITSRFRGSANYSAMTDPRIGMIRRLVGAKRKRGGCDDAGRGEKMSPSWIDEQDGWISSSPGNMLDTDMDDPRSESESGSDSGDLEGLFTEERDAKSVSRPHTPPPAYLPLGPTLVQTQFCHQYLLPLSIPLRPPGVGIQNPAATAPMSVPTPVSPAAVLGAMSEKSKALEDAAQILVKEVVENCVWATVWRANAVAAQGATNSSSKLWQVDVKSVHKLLSLSGIPSSLSLEEVFSDEVADTVSLQVLGRPLLSVGKSDSIIQVLPSALRFWEKLGLSPRSGSKDVVAFVFTDRYDEEKGRCVTTWLDRMSIVYAAKNFGKHSVGHAAECIVDGVVSVNFDAFRKMLPLFVENVTKSTDGNHCTVVLYVVLPAHIMNLASPVLRHVLSAIKRVNRKFKNSDILFQFIPEPFVVGSLDDPSANNSGLEPLVESLYDRIRLPARRTMSRKILPADEKKTRALFQEPAYTLARSLHSKVKFVREAHASTLDVMDRHTLLQVGYHISPCRKWLFAACTDQRAEAHNVRAWLMPTDSRESFVVARIWDFAQSMAMKASIEWHIVITKVGSMSATEFDAWISQLNSETFTNIDLPPVQTSILVAQPDDPWMFLAPEHAPVIKSPASTSRTPKVATGSVVQDISASFYILDTTLRPTIPSPSHEYVAERTCIPDAEEEEPTEELGLRSRSSITLIRVPAGTDYTPISMLHLHLLHSGRSTYSSAIESEVAILYDVTRNFSDLLTVTQHRWKLKANPLLPFHLAALEVMHATLDTGDVLVD
Length1639
PositionKinase
OrganismPhlebia centrifuga
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Polyporales> Meruliaceae> Phlebia.
Aromaticity0.07
Grand average of hydropathy-0.179
Instability index57.06
Isoelectric point5.87
Molecular weight177239.20
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19694
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      66.08|      21|      23|     719|     741|       1
---------------------------------------------------------------------------
  148-  170 (23.28/ 8.67)	TPCTTClNPASPLATSS....APsSSQ
  443-  462 (25.26/ 6.65)	TAPTIS.QRATSMPVSS....EG..GL
  732-  751 (17.55/ 6.46)	PPPTLS.TGMI......psglGPpSGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     133.32|      20|      23|     274|     293|       2
---------------------------------------------------------------------------
  274-  293 (38.31/21.03)	PILRPT.HYLP.LSNILPA..PAG
  300-  316 (27.06/11.92)	PLGVPA.YYL....NIYSG..PVG
  389-  412 (22.67/ 8.37)	PHVRPPlEYIPsLPTQLQAspPAL
  779-  793 (21.59/ 7.49)	AMLPPP.ELLP.......A.tPAL
  997- 1012 (23.68/ 9.18)	P.LRPP.GV.G.IQN..PA..ATA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.11|      10|      17|    1372|    1383|       3
---------------------------------------------------------------------------
 1372- 1383 (15.81/16.82)	RKWLFAacTDQR
 1390- 1399 (21.30/12.88)	RAWLMP..TDSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     493.33|     139|     696|     105|     271|       4
---------------------------------------------------------------------------
   22-   95 (69.56/25.63)	..........................................................................PPrislASPLLA........SAIDLPSQPL.IVYSVYTPISGQP.GVDPLY.ALEQARRRIVEKNS.SRTVVDSLLPSVHLSRDSS.......................................................
  105-  271 (227.20/112.08)	THKPSASQTALQGAQFDDLILAESSQFS....LTGLY....PCSDPCSTQrtpcttclnpasplatssapsssqPP....PAPWTS........SACLLPRKPLRGPYSRFTQAVRDR.LIDDVTRASKTARASATERAA.VRLKGGFLLSSPASSSASEWGTGWD..........................HYTLQRTLVhcelQIQLCSSRLL
  815-  992 (196.56/88.87)	TYRRNGSIGNLSPSAFDPIPFARSHKMAdgkyLMGKFalpsPPDEEDRTQ..............................PIPITSrfrgsanySAMTDPR...IGMIRRLVGAKRKRgGCDDAGRGEKMSPSWIDEQDGwISSSPGNMLDTDMDDPRSESESGSDsgdleglfteerdaksvsrphtpppaYLPLGPTLV....QTQFCHQYLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.20|      17|      23|     603|     624|       5
---------------------------------------------------------------------------
  603-  621 (21.79/23.57)	AAG..ITSASDVrQPSAvEPI
  627-  645 (26.41/ 9.05)	ADGndTTSESAV.TPTS.DPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.65|      14|      17|     695|     708|       6
---------------------------------------------------------------------------
  695-  708 (27.89/15.11)	F..TDDDFNFFDAPAP
  713-  728 (21.75/ 9.94)	FaaTGSGLTPAAGPAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     122.46|      24|     664|     419|     442|       8
---------------------------------------------------------------------------
  419-  442 (41.74/23.96)	VKLVRRSLTPATVLSGAPSP......FSEQ
 1016- 1034 (21.21/ 8.09)	...VPTPVSPAAVL.GAMSE......KSK.
 1044- 1065 (33.65/17.70)	VKEVVENCVWATVWRA..NA......VAAQ
 1079- 1104 (25.85/11.68)	VKSVHKLLS....LSGIPSSlsleevFSDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.92|      20|     668|     465|     485|      10
---------------------------------------------------------------------------
  465-  485 (34.10/22.20)	PKPVRPV....LSPRSPTSDSLrAF
 1132- 1155 (32.83/16.45)	PSALRFWeklgLSPRSGSKDVV.AF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.86|      18|     708|     754|     778|      11
---------------------------------------------------------------------------
  758-  778 (26.50/30.46)	PWMtqVLGEAFTPhSIDTPVS
 1469- 1486 (36.36/15.66)	PWM..FLAPEHAP.VIKSPAS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19694 with Med13 domain of Kingdom Fungi
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