<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19674

Description Mediator of RNA polymerase II transcription subunit 20
SequenceMGVTVLQQFPMVENRTGPQTIEFLTKRVMALGAIQTGQFLVDCDTYMSVASLGQQRTVHVLHNSEQPASVFSILESGNKTIPLVADGLFDLLMMKMTSIYTSKKQTKIEAKGPRFEIGDFCVKLGSVTMSQNFKGVLVEVEYRPCVVPASCWELMREFLQGFLGSSVQSTAPQYLQNRMNEVYQPIDTIHQYLEQFGAYRKSTGVR
Length206
PositionHead
OrganismBlattella germanica (German cockroach) (Blatta germanica)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Polyneoptera> Dictyoptera> Blattodea> Blaberoidea> Ectobiidae> Blattellinae> Blattella.
Aromaticity0.09
Grand average of hydropathy-0.081
Instability index41.89
Isoelectric point7.66
Molecular weight23121.50
Publications
PubMed=29403074

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19674
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.43|      15|      15|     163|     177|       1
---------------------------------------------------------------------------
  163-  177 (25.75/16.31)	LGSSVQS..TAPQYLQN
  179-  195 (22.69/13.65)	MNEVYQPidTIHQYLEQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.27|      11|      22|     111|     122|       3
---------------------------------------------------------------------------
  111-  122 (17.96/16.26)	KGPRFEIgDF..CV
  134-  146 (15.31/ 7.93)	KGVLVEV.EYrpCV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19674 with Med20 domain of Kingdom Metazoa
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