<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19668

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMAADESSWRTAAFRQSVVAKIDEAIQRSGMPTSKNSLEMENHVFQKAKTKEEYLGFVARLILHVREMNSKKGATGMGVPGAGGGQAAQDPINALQNLARQGTGNQIMGLGGPQAGGMVQPSSIPASSLLQTLNQRPPQGLPGMQPMQNKMPGDMGLGPGPQVGPPMVGMPGQMQPGPMPNVACPSQMAGQIPNQMRVPMPGQIQGQPMGQIPQMPGQMGGQMQSQMTHMAQLQQQQRKGNEAMMMAANQSAGFPGPRNVASNSFLRQSPSPSALQASPAGLGAAPSSNQMAASPAHVPSPSAQLTPMSSAQRSDVEKLSKMKKLLEILSNPSKRMPLETLLKCEAVLEKLKRGEGSVTAQPTHFPLKEHHIFNPLLEAVNSALQSPVANHTLQRTFGPCLEALFGPEIKMLPPPLKKKKVEETPNDIPDVLQGEIARLDQRFKVSLDPTQQPGSRSVQLLCWLDDRHLPCVPPVSLSVPEDYPHSPPRCHMATHEHSSTQFLSAVQKALASRIRKLPSRFSVSQLLDTWEMSVRQASAPTQTPVSATTVLMGF
Length553
PositionTail
OrganismBlattella germanica (German cockroach) (Blatta germanica)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Polyneoptera> Dictyoptera> Blattodea> Blaberoidea> Ectobiidae> Blattellinae> Blattella.
Aromaticity0.03
Grand average of hydropathy-0.419
Instability index60.86
Isoelectric point9.54
Molecular weight59383.86
Publications
PubMed=29403074

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP19668
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     160.05|      27|      28|     169|     195|       1
---------------------------------------------------------------------------
  116-  148 (30.33/ 8.04)	..GMVQPSSIPassllqtlNQRPPQGLPGMQPMQN
  150-  166 (33.48/ 9.67)	MPGDMGLGPGP........QVGPP..........M
  169-  195 (61.75/24.26)	MPGQMQPGPMP........NVACPSQMAGQIPNQM
  199-  214 (34.49/10.19)	MPGQIQGQPM..................GQIP.QM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     102.65|      24|      28|     267|     290|       2
---------------------------------------------------------------------------
  223-  250 (29.36/ 9.79)	QSQMTHMAQlqqqqrkGNEAMMMAA...NQS
  267-  290 (44.26/18.24)	QSPSPSALQ.......ASPAGLGAAPSSNQM
  296-  314 (29.03/ 9.60)	HVPSPSA.Q.......LTP..MSSAQRSD..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      82.95|      24|      27|     372|     395|       3
---------------------------------------------------------------------------
  365-  379 (21.96/10.31)	......PLKEH...HIFNPLLEAV
  380-  403 (42.01/26.78)	NSALQSPVANHTLQRTFGPCLEAL
  408-  423 (18.98/ 7.86)	IKMLPPPLKKKKVEET........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.37|      19|      30|      68|      86|       4
---------------------------------------------------------------------------
   68-   86 (35.53/18.01)	NSKKGATGMGVPGAGGGQA
   96-  114 (35.84/18.23)	NLARQGTGNQIMGLGGPQA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19668 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NSKKGATGMGVPGAGGGQAAQDPINALQNLARQGTGNQIMGLGGPQAGGMVQPSSIPASSLLQTLNQRPPQGLPGMQPMQNKMPGDMGLGPGPQVGPPMVGMPGQMQPGPMPNVACPSQMAGQIPNQMRVPMPGQIQGQPMGQIPQMPGQMGGQMQSQMTHMAQLQQQQRKGNEAMMMAANQSAGFPGPRNVASNSFLRQSPSPSALQASPAGLGAAPSSNQMAASPAHVPSPSAQLTPMSSAQRSDVE
68
316










Molecular Recognition Features






MoRF SequenceStartStop




NANANA