<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19663

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMDKAKEWQMELLMEKLRSKAGQFKPFVESAKALRMSLLASIHEKRYPVDSVERNQLQKCLDILQHSIKVTSLQGMVERLESVTRQLGLKFSPGVNTYDWFISSDMFYIEVILEPTGAINDVRIHHEGKNEQQTCEELVSCLSRGDFADFTAQLEGLTSIYQLNAEKKVKCKAFSALQSLEADLGTLATLQTFIKEAFNLVHKSPVGILEKRRGGHAMKLTYLVPPYDLLDQQNKTSLPLSVEEVTSKNIGYSVMVCMEGSPAHKLQTTPLISVNRSPNGKSSPQYAALNTTNSATLPACFVLRLNNPMPMCLALVRRIQQVTEMECGDLSSPHPLLSLVTQHASAGQLDCANNRGLFVTLPDQQHCYFMTESKNLEGILVSNIPFSHPAHVPQILGLLRQQALFNVLVSSCIRPSSKNADLESMIMFEVTALSWQHLSISFEHPLEETMTTAELDLGDIASIKCKVYGASNGENGCTPEHVSKVLQRCWSIPVTMRSLIRSWQSQTLRSNGLSTGGNLSLPPGGDPGRGHGGTNGNHTMNPDFDVSRVKTEPDSGGLSHGQSIGGSGNRQGFGTDMSDASVGFQSPGNPSDSSVSNAFQFGELLSGRGSGGKGTALLNMLGEQTTSGKKQRKRSSKAAGDGMWRSPKRKHSEDCEIVLESSSSDSTPLGTPTSRDAPMETSLDCEDEKPGSDFGEEEIMPMADVEDVIVKKPKKEKKTSPPTIILDLESKNMVAPSVSITPITSSSSSFNSVLTGMGLERRPGIEIIPIVSTPATSLPTSITITPISSKPVPAEERNNRERKSGKSRTEDKTRPDNKKRSKRKRDDSPNSNSNSGVAMGPPDKLPPKQDPLNKPVTVSIKATESPPLSSVRPSSPASTLRKITSSPTHMSLSVSSKSGSSKQSSSHQSPKHSPGYTSSPKHHGTSSPKHQSSGGSGKPSMSALKSAASSPSSTGKSGSDVPKAKSSSNKDKDRKVSSSFSGSSSSSSSGPGSSPKLKSSSVKLKQIDLSSVSGEGSQSGGGTPPSGSTDSGKSSTTTPQGRNRKGSLSAVIDKLKSAQHQGPETSEGAKERSGSSNPTSKTQGDVSGSNVSKNPGEYMVKPSSDGMKITINKTRTKDPKQSSAKSSSSSTGSGSPKTHTGLKPGVNSGPASKKPHPLIQQKSTGSISNSSSGSSKTSGSSNPSSSSKNSSTKSSSSPVSGLLSKSNSSKSSGSPKMSSLSDSSRRENKPRPPKSSSDRSDREKSIFLKAQDARKSSPGGMRDEVEGGMKAVSAHVKMEPSLPPQLMVEGMMKQLDTKFQIPKLSARSSSSLAEGDSKKQSSTEKAAVVTSADSGGRMDSGAKPLDLVGKGDSSNASTKFSSLSKAPDEVKVSKISPLGSVTSPLALSGLTPTLKSSPTTSFPSIGSKSQDITIDTGPSNTAPLATSNEPSSGDGADVPRIKSDLSRGGQSSGTSIKEETLVPSVGKLDAANKSFSNSSNNDPLPLSLHSTKSLDSSQTKFSASSQKQVEDSKKLVNLSDIANKSTTGLNKMTPVSTTSQEAAEILLDMSSSSSLPNKPPISEPPQAKLATVPERAVAVSAPTRRNTPPPPLPPPQPSVQVHIVQSPAAAPATASPMVIPSPHSASPCSIDDDLMDEALVGLGK
Length1643
PositionMiddle
OrganismBlattella germanica (German cockroach) (Blatta germanica)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Polyneoptera> Dictyoptera> Blattodea> Blaberoidea> Ectobiidae> Blattellinae> Blattella.
Aromaticity0.03
Grand average of hydropathy-0.605
Instability index60.64
Isoelectric point9.34
Molecular weight173365.43
Publications
PubMed=29403074

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19663
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     109.46|      30|      31|     948|     977|       1
---------------------------------------------------------------------------
  903-  933 (32.60/ 7.38)	SSSHQSPK..HSPGYTSSPKHHG....tSSPkhQSSG
  955-  989 (42.33/12.00)	KSGSDVPKAKSSSNKDKDRKVSSsfsgsSSS..SSSG
 1100- 1131 (34.54/ 8.31)	KPSSDGMKITINKTRTKDPKQSS...akSSS..SSTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.16|      27|      31|    1159|    1189|       2
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 1004- 1030 (31.55/ 6.61)	KQIDLSSV....SGEGSQSGGGTPPSGSTDS
 1159- 1189 (39.61/17.19)	QQKSTGSIsnssSGSSKTSGSSNPSSSSKNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.64|      21|      25|    1454|    1478|       3
---------------------------------------------------------------------------
 1454- 1478 (25.46/19.13)	SIkeeTLvPSVGKLDAANKSFSNSS
 1484- 1504 (32.18/13.51)	PL...SL.HSTKSLDSSQTKFSASS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.38|      18|      25|    1257|    1281|       4
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 1260- 1281 (23.09/30.64)	MrdeVEGGMKAVSAHVKMePSL
 1286- 1303 (32.28/14.11)	M...VEGMMKQLDTKFQI.PKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     137.46|      25|      25|    1572|    1596|       5
---------------------------------------------------------------------------
  850-  872 (35.00/ 9.77)	PLNKPVTVS..IKATESPPLSSVRP
 1383- 1403 (27.22/ 6.07)	PL.ALSGLTPTLKSSPTTSFPS...
 1572- 1596 (45.97/14.98)	PERAVAVSAPTRRNTPPPPLPPPQP
 1606- 1626 (29.27/ 7.05)	PAAAPATASPMVIPSPHSASP....
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     209.81|      69|     493|     224|     298|       6
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  224-  298 (106.17/61.26)	PPYDLLDQQNKTSL..PLSVEEVTSKNIGY.SVMVCM..EGSPAhkLQTTPLISvnrSPnGKSSPQYAALNTTNSATLPA
  720-  793 (103.64/46.67)	PPTIILDLESKNMVapSVSITPITSSSSSFnSVLTGMglERRPG..IEIIPIVS...TP.ATSLPTSITITPISSKPVPA
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     108.25|      23|      25|    1517|    1539|       7
---------------------------------------------------------------------------
 1201- 1224 (32.94/11.58)	LLSKSNSSkSSGSPKMSSLSDSSR
 1517- 1539 (37.68/14.41)	LSDIANKS.TTGLNKMTPVSTTSQ
 1545- 1565 (37.63/14.38)	LLDMS..S.SSSLPNKPPISEPPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.15|      18|     194|    1227|    1244|       9
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 1057- 1074 (28.08/12.66)	AQHQGPETSEGAKERSGS
 1227- 1244 (29.08/13.41)	NKPRPPKSSSDRSDREKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     226.20|      50|     820|     503|     552|      13
---------------------------------------------------------------------------
  467-  527 (66.70/27.24)	..YGASNGENGCTPE..HVS...KVLQRcwsiP.vtmrslirswQSQTLRSN...GLSTGGNLSLPPGGDPG
  528-  568 (65.29/26.51)	RGHGGTNGNHTMNPDF.DVS...RVKTE....P...................dsgGLSHGQSI....GGSGN
  569-  606 (46.91/16.94)	RQGFGT........DMsDASvgfQSPGN....P............SDSSVSN...AFQFGELLS.......G
  801-  849 (47.31/17.15)	RKSGKSRTED...............KTR....PdnkkrskrkrdDSPNSNSN..sGVAMGPPDKLPPKQD..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.48|      17|      18|    1317|    1333|      15
---------------------------------------------------------------------------
 1304- 1329 (18.42/ 7.11)	SARSssslaegdsKKQSSTEKAAVVT
 1330- 1348 (22.06/10.30)	SADS.......ggRMDSGAKPLDLVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.17|      12|     820|     325|     336|      17
---------------------------------------------------------------------------
  325-  336 (24.49/12.08)	ECGDLS.SPHPLL
 1146- 1158 (19.68/ 7.98)	NSGPASkKPHPLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.99|      25|      63|    1350|    1374|      19
---------------------------------------------------------------------------
 1350- 1374 (39.80/19.08)	GDSSNASTKFSSLSKAPDEVKVSKI
 1416- 1440 (42.20/20.75)	GPSNTAPLATSNEPSSGDGADVPRI
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.16|      43|     256|     414|     465|      20
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  414-  465 (62.70/57.94)	PSSKNADLEsmimfevTALSWQHLSISFEHPLEETMTTAELDlgDIASIKCK
  671-  713 (76.46/47.22)	PTSRDAPME.......TSLDCEDEKPGSDFGEEEIMPMADVE..DVIVKKPK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19663 with Med1 domain of Kingdom Metazoa
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