<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19655

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMAQKGGVNIGGVKSLKGEKNEKGIRGSGRGGVMPFHRRSPLAEDGAWAVEVAGPLSRLVGGSGTSPGGPPSYPRGQSMTPNPLPNLHGGGESLPVPSVGSPASAAPSPLPNPHSQPASVPPADPTMPTLSPHPPASNSGAGQPQPATPLESQDKVTPAATPSDLNGPKSVSSVSNQVFSPYPATSSVEPATKPVDSVGGGSQGPASAHSVAAPAPASNAMPPDYVTLKRPILSSKEYESILMEEEQPSELLYDYSTLDAWLNHPVKRFKPLETRQSDSMRPNPYNKRMSPNDLYSNHMQQQNVASPPNNLNQPFIKQEIKQEPGCNIPMEVDNVHPNKRSDPYEFEDDMTTPAMEGFKRTNSVKEEDRKGAPGNAIGPFDPVTPNGPTNKPTSLFTNEGLQASYKDLDQIFDNSDDTSSDETLQVPTPPGSNKPAGLPEDSASSSVVVKPPRGSGGNTSLNSCGGTGILRPEELSKMFPTPPSMEPNPIASPCGHLSDGPLGELSDGPVGHCITRYKQEIYPNMGSPQEENIEDWSFVFKPPTICKFVGSSKYAPLTNLPSQSLPPVPLPAHCVYKPSWQTQYQQQQQQQQQQQSSEKSASQHGIPNGSLVPSGPGTNSRPNSVASNHHSGGGIPPHPHHPHPNIHHPPMPPHPHSRAGLSPISPAGHFPPSPMMAMGGGGMPMHMQQQFRTGGPGSVGGVRTPCPAPPPYELPSPATSTASSYLNKNLNSVEPVQTPIMARAPEANSLVVNILLGDTALNIFRDHNFDSCTLCVCNAGPKVVGNIRGADAGVYLPAPPSQSQPALPFPPTSPFPGIGMNGPPPPYMMGSSPGHHGVTPNVMGMVTEEDPIRCSCGFSAVVNRRLSHRSGLFYEDELEITGIAEDPGERRKGSLLAYLLPNSSKGGQENGNTEMIDLVPQNVMELLKEQCVIIQSSCNSLYRASRQFRGTLGPDVPYGTTVNVLEFMDGNEVTYMALDQGRQALLESTTVAMCKVEEMQQRQQIMQHGGKSSNTPCVHRWPYLRALGPQCNQDIVWVMKSLRPLLQEVIHKKCTTRLWDAPYTVNGPLTWRQFHRLAGRGTDDRCEPQPIPSLVVGYEKDWLSLSPYAVQYWEKLLLEPYSYARDVAYIVVAPDNDYILQRVRTFFKELSATYEVCRLGRHCPITKVLRDGILRVGKTAALKLAKEPVDEWFTVLGDNLTTNMLKLYAQVCRHHLAPHLSQITLDKTLLDPPESSQTPRSSVDRPMPSPMPPPSTPESNQSQIPDKAPSTPKSDHDGEGSSNARDPLLSGGPLGGGDSNHDDDDSEPPAVVVYLVDPFTMGSDNTDLQRLACLGLLRCFTTVLASVPESIRNNISVQCRRMLTHTSNIKALTGFGTAAMADLFLKNKDEKNRAPYRLYTPPYVLAPVKEKTESGESFGQCSGEQCSVLYVSYCLSEDQRWLLAVATDERGEIFETSTVNIEIPNRVRRKKASARRFGLQKLMDFILGVMSQSVRPWRLVVGRIGRIGHGELKGWSWLLSRKSLLKASKHLKEICQQCSLMYPNDVPCVLSACLVSLEPDSTLRLMPDQFTPDERFSQTSVNCQLSTPHDVSCTHILVFPTSATSQSSQTAFQEQHINGPELGDDELFSALNDDMPEGIEGMQDLSDIFSWPEPGPGGAQSPTGSPRRGDSPSQPGSPSCGVGGASDQHSPFPCNGSSRGGGSLGVDTQEEVGTLHQQPLALGYFVSTAPTGRMPRWFWASCPHLENVCPAFLKNALHLHSPAIQQNSDDLLQQQSAVTVHPLDSQYTTDVLRYVLEGYNALSWLALDSNTRDRLSCLPVHIQALMLLYHMSSALV
Length1835
PositionMiddle
OrganismBlattella germanica (German cockroach) (Blatta germanica)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Polyneoptera> Dictyoptera> Blattodea> Blaberoidea> Ectobiidae> Blattellinae> Blattella.
Aromaticity0.06
Grand average of hydropathy-0.495
Instability index62.35
Isoelectric point5.97
Molecular weight198649.57
Publications
PubMed=29403074

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19655
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     182.03|      23|      89|     429|     451|       1
---------------------------------------------------------------------------
   84-  106 (29.13/ 6.91)	PNLHGGGESLPVP.....SVGSPASAAP
  428-  450 (36.92/11.02)	PPGSNKPAGLPED.....SASSSVVVKP
  451-  471 (28.91/ 6.79)	PRGSGGNTSL..N.....SCGGTGILRP
  798-  815 (29.13/ 6.91)	PPSQSQPA.LPFP.....PTSPF....P
  816-  839 (28.66/ 6.66)	GIGMNGP...PPPymmgsSPGHHGVT.P
 1655- 1677 (29.28/ 6.98)	PGGAQSPTGSPRR.....GDSPSQPGSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.55|      11|      15|     627|     639|       2
---------------------------------------------------------------------------
  627-  639 (19.02/10.31)	N.HHSggGIPPHPH
  644-  655 (23.53/ 6.76)	NiHHP..PMPPHPH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     680.96|     103|     222|     111|     213|       3
---------------------------------------------------------------------------
   33-  119 (79.33/28.72)	......M..P.....FHRRS....PL.......AEDGAWA....VEVAGPL.SR......L.VGG.SGT..SPG..GPPS...............................................................YPR......GQS....MTP..N.P...............LpnlhgggeslpvpsvgspasaapS..........................PLP.................................................NPHSQPASV
  120-  220 (173.38/73.18)	PPADPTM..P....TLSPHP....PA.......SNSGAGQ....PQPATPLESQ......DKVTP.AAT..PSDLNGPKSVSSV.........SN........QV...................................FSPYPA......TSS....VEPATK.P...............V.......................DSVGGG...........SQGPASAHSVAAP.................................................APASN..AM
  221-  303 (94.75/36.00)	PPDYVTLkrP....ILSSKE....YE.......SIL.MEE....EQPSELL..Y......DYSTL.DAW.....LNHP..........................V.................................krF.......................K.P...............L.......................ETRQSD...........SMRPNPYNKRMSP.............................................ndlySNHMQQQNV
  306-  484 (91.84/34.63)	PPNNLNQ..PfikqEIKQEPgcniPM.......EVDNVHP....NKRSDPYEFE......DDMT....T..PA.MEGFKRTNSVkeedrkgapGN........AI....................................GPFDP......VTP....NGPTNK.PtslftneglqasykdL.......................DQIFDN...........SDDTSSDETLQVPtppgsnkpaglpedsasssvvvkpprgsggntslnscggtgilrpeelsKMFPTPPSM
  485-  564 (81.72/29.85)	EPN......P....IASPCG....HL.......SDGPLGElsdgPVGHCITRYK......QEIYPnMGS..PQEEN....IEDW.........S.........FV...................................FKP.PTickfvgSSK....YAPLTNlP.........................................................................................................................SQ..SL
  565-  707 (95.94/36.57)	PPV.P.L..P....AHCVYK....PSwqtqyqqQQQQQQQ....QQSSEKSASQ......HGI.P.NGSlvPS...GP.GTNSR.........PN........SVasnhhsgggipphphhphpnihhppmpphphsragLSPISP......AGH....FPPS...P...............M.......................MAMGGGgmpmhmqqqfrTGGPGSVGGVRTP.................................................CPA......
  708-  792 (64.01/21.47)	PP.......P....YEL...........................PSPATSTASSylnknlNSVEP.VQT..PIMARAPEANSLV.........VNillgdtalNI...................................FRDHNF......DSCtlcvCNAGPK.V...............V.......................GNIRGA...........DAG....................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     171.44|      50|     222|    1487|    1595|       4
---------------------------------------------------------------------------
 1224- 1276 (87.52/29.15)	LDKTLLDPPESSQTPRSSVDRPMPSP....MPPPSTPESNQSQIP.DKAPSTPksdHD
 1535- 1589 (83.92/29.83)	QQCSLMYPNDVPCVLSACLVSLEPDStlrlMPDQFTPDERFSQTSvNCQLSTP...HD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     147.40|      44|     419|    1277|    1321|       5
---------------------------------------------------------------------------
 1277- 1321 (76.41/40.24)	GeGSSNARDPL.LSGGPLGGGDSNHDDDD.....SEPPAVVVYLVDPFTMG
 1682- 1731 (70.99/33.58)	G.GASDQHSPFpCNGSSRGGGSLGVDTQEevgtlHQQPLALGYFVSTAPTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.11|      41|     417|    1016|    1101|       7
---------------------------------------------------------------------------
 1056- 1101 (67.49/100.30)	RLWDAPYTVnGPLTwrqfHRLAGRGTDDRCEPQPIPSLVVGY....EKDW
 1396- 1440 (69.62/23.54)	RLYTPPYVL.APVK....EKTESGESFGQCSGEQCSVLYVSYclseDQRW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.26|      10|      15|    1009|    1020|       9
---------------------------------------------------------------------------
 1009- 1020 (16.30/12.97)	GKSSNTPCVhrW
 1027- 1036 (21.96/10.20)	GPQCNQDIV..W
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.81|      13|     223|    1514|    1534|      10
---------------------------------------------------------------------------
 1514- 1534 (19.79/21.24)	WSWllsrksllKASKHLKEIC
 1736- 1748 (30.03/14.50)	WFW........ASCPHLENVC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19655 with Med13 domain of Kingdom Metazoa
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