<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19654

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPVPLEGHQTPVGNNVPQEGSRGGSISLAVLIDFIIQRTYHELTVLAELLPRKTDMERKIEIYNFSARTRQLFVRLLALVKWANSASKVDKSAHIMAFLDKQSLLFVDTADMLARMARETLVHARLPNFHIPAAVEVLTTGTYSRLPACIRERIVPPDPITPSEKRQTLLRLNQVIQHRLVTGNLLPQMRNLKIESGRVTFTVEHEFEVSLTVMGDGPNIPWRLLDIDILVEDKETGDGKALVHSLQVQYIHQVIQSRLVDNPQPLTEVYNCLHFFCQSLQLEVSIKAIYVNVYKAQPPRIYLELTCKDPRSELGYRLTVQVDTHDPARPLTVVHVPSLGNKECEIADRAIRSDLLSMERLLVHTIYVRTRSRLTELKQELQTMLKDVECHLQGSPAILSVPVLQPCLRAEQLLVTVDTHTGMLQCHVPQYDAPLIPELQTALNGDHSRLPTLVSELRYWITQRRCEKTLQHLPATPHERLPLLHHPDHPMSKIGRHRMFVRLHRHPNVILIVEFKEKESTPCEIDCSFYLAVVKHSSIEDDPHDDTIETEIPKMYLKVMTLIEFDTFVITHGPFTSVDDQSEKIPGKRKSGGRPEPGSRRTKQPAYFIPELAHVVALCDERLPFVTLAQEVEANATALVLRLVQLPPPPGIDTQSTSWLALLKRLLSVAIRVQGKSTKSWMAEFVFYGSPLASSHPKEQGLRRPVYFQYDMGTAETVSKTVDLLLCDWAQIVHLYTVVEELAEYFRIEKYNLSNMVTIKSYSYSRLVLGYGPDRGATVTIDWNSTDKAFRLIFGAANNCVNAHSLMREQLEAHLNRHRNLAQIVHLLHETYEPLISISKLPTIPQLGVHNQRPQVPVQTFTIMPQSPTLLRLAYQGMYCLELRLRGGGLVSLRDGAYSRFDRSNVVEEFTPTQGLKAFLSKYVDETAVFRRRSQSEDDNPPSPITMDSDGAGPMSFLGAHHRGPQSPAQQREGGLRFHPPLTPPSGSNPHTPASPHPTMSQASQHQSFGSSPAASFNLASPPSLPPNINPSPNMLPHPSPGGLLANSPSNPLHVPSPAGLMPTSSPGPCPTVPVIQMAAHFLRPRAWPPLPRPTGLVLPACLALRQHDQGSHLGVRGIRPYTAHRPTISQLTGIPTTEPGVVNFKVESLQCRVGLNPQHLQSLHIKVTPLPDHKEQWTAEEMQIIEKFFDTRAAAPPYKPNALSGFGRMLNVPYNVLKDFVQIMKLELVPGLVQQQQLKWAVQWSLRIPPSATPIVPTGMAAVLLCRTKILFFLQITRVGGPYPSTMEAPSLVLPLVYDVSTNLTQLAEKRDLGPASATAAASHQLKRFAEFGVSPNECSLFPAVRDLLANLILPSEPPLQPSPAMQMHSPMPGGVVGMPPQQPVAGGPPQQPGGPPQPPYPVGIAMGQHPMMGPQ
Length1418
PositionTail
OrganismBlattella germanica (German cockroach) (Blatta germanica)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Polyneoptera> Dictyoptera> Blattodea> Blaberoidea> Ectobiidae> Blattellinae> Blattella.
Aromaticity0.06
Grand average of hydropathy-0.212
Instability index55.98
Isoelectric point8.49
Molecular weight157830.43
Publications
PubMed=29403074

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP19654
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     117.83|      23|      23|    1021|    1043|       1
---------------------------------------------------------------------------
  943-  972 (24.20/ 6.77)	PSPIT.MDSD.....GAG.......pmsflgAhhrGPQS......PAQQ
  991- 1031 (27.31/ 8.82)	PHTPA.SPHPtmsqaSQHqsfgsspaasfnlA...SPPSLP....PNIN
 1032- 1056 (33.24/12.74)	PSPNM.LPHP.....SPG..........gllA...NSPSNP....LHV.
 1364- 1394 (33.08/12.64)	PSPAMqMHSP.....MPG..........gvvG...MPPQQPvaggPPQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.72|      11|     106|     978|     988|       2
---------------------------------------------------------------------------
  978-  988 (25.01/ 9.39)	RFHPPLTPPSG
 1087- 1097 (24.71/ 9.16)	RAWPPLPRPTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     314.96|      66|     105|     598|     663|       3
---------------------------------------------------------------------------
  430-  484 (64.09/40.05)	........PQYdapL.........I.....PELQTALNG...........DHSRLP..TLV........SELRYWITQRRCEktLQHLP...........ATP......HERLPL
  491-  585 (53.42/31.85)	PMSKIGRH.RM...F.........VrlhrhPNVILIVEFkekestpceidCSFYLAVVKHSsieddphdDTIETEIPKMYLK..VMTL.iefdtfvithgPFTSVDDQSEK....
  598-  663 (108.79/74.37)	PGSRRTKQPAY...F.........I.....PELAHVVAL...........CDERLPFVTLA........QEVEANATALVLR..LVQLP...........PPPGIDTQSTSWLAL
  698-  770 (88.66/58.91)	PKEQGLRRPVY...FqydmgtaetV.....SKTVDLL.L...........CD.WAQIVHLY........TVVEELAEYFRIE..KYNLS...........NMVTIKSYSYSRLVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.89|      26|      34|      95|     123|       4
---------------------------------------------------------------------------
   95-  123 (38.73/39.23)	HIMAFLDkqsLLFVDTADMLARMARETLV
  131-  156 (45.16/35.49)	HIPAAVE...VLTTGTYSRLPACIRERIV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.85|      23|      34|    1283|    1305|       5
---------------------------------------------------------------------------
 1283- 1305 (41.43/23.38)	GPYPSTMEAPSLVLPLV.YDVSTN
 1316- 1339 (35.42/18.89)	GPASATAAASHQLKRFAeFGVSPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.05|      23|      94|     300|     326|       9
---------------------------------------------------------------------------
  300-  326 (33.58/32.93)	PRIyLELTCKDP..RSElgyRLTVQVDTH
  397-  421 (36.47/20.66)	PAI.LSVPVLQPclRAE...QLLVTVDTH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.89|      14|      76|     173|     189|      12
---------------------------------------------------------------------------
  173-  189 (21.88/17.78)	LNQVIQHRLVTGnllPQ
  252-  265 (27.01/13.94)	IHQVIQSRLVDN...PQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19654 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PLQPSPAMQMHSPMPGGVVGMPPQQPVAGGPPQQPGGPPQPPYPVGIAMGQHPMMGPQ
2) VFRRRSQSEDDNPPSPITMDSDGAGPMSFLGAHHRGPQSPAQQREGGLRFHPPLTPPSGSNPHTPASPHPTMSQASQHQSFGSSPAASFNLASPPSLPPNINPSPNMLPHPSPGGLLANSPSNPLHVPSPAGLMPTSSPGPCPTVPVI
1361
930
1418
1077










Molecular Recognition Features






MoRF SequenceStartStop




NANANA