<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19652

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGRLVMDVKEPQGLGGLKRDGSHLSQQSEGREQKRVASDASRAKLNGAPLSPSGANTQADAPVINGVLHENNGGVKQEASAHLGIAGGEAPELEQYRDTLVPLGKIIERMAQQTYFDLSEAIESLADIQISNQAQLTNGVGGPVSQDKSRESLHKKERLLNFAQTHKDRFIKTLVLSDWARNMDDMSKLIDVSMFLRKQDWATHGAADSIYRLKENMIGAKMPNPNIEGALELLSTGEAPWMPDMGYIPPKSLTAQELLDTLSDMNFALSVRLNLHEDLPPHFQKYSIANGRATFTVDGEFEVDLAVADDDPESFFYFIDIRLLCSPTTEFNNDRLRNQLEARMNEVLATSGLDGCYNFLHNFVLTHKLNVLRCQALQLARGKWIDNIDVQAIHRSVVVHYWKNQNGGKNWIELGIGSGKQGSGTKRKPLPQISCRWFRRGQEVTDHDLDFNFTNISMEDMLEQVIAKHISGRLTALSAGLGSLAPDTSCLTQELVTSSVESSDCSLRLGMRGTNTAMTITTDPIRGAYCVQPQSSATREIERRLNNDPLVDAPAVLRFNICRQQLGQIEIRVRGLGLNRIDATSHKGSASQILREAVVFTTLQRLSWGSETKSMANCALTLTYDLVDGPTWYLARLGESKDGRHIATLEALNTEDETMRKVDIRALLRIERAALEISCASSTASDLGKPEALLPGQSFQQPDAQSTGREGQLRFPMAYNPNKLLLGRSVSKSVAQGVHIFSNTGALDMEIPRDDDDNAGIIYYFRTNLHSSVMTKTIQLLFRSLKGEQGIWVGAKGEVQIMVRAALGTPIKLKLQAKLQSVSNFCAYVDVLGSNHFAVISLEFDSIKFSYAPRLTCRVRLSGEDTSPLLDFGLQGNTGSTDENPHASLRKQLETVFVPSDVFAPRTTLSSEKLANFCQVLRATLSIIKCAKTFESREPVASSLLHCHNALDLRITYRAPLPILSFSINGRTREGRVSWWVKPIITTQDDQLRSTLGQMFKSKGEGWHGTRGGVIATVEGIGPLLNQIDEVIRNLARQPTQPQTKPAQQAVQQPAPQRTASKTNKGRGQEVVVLD
Length1076
PositionTail
OrganismElsinoe australis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Myriangiales> Elsinoaceae> Elsinoe.
Aromaticity0.06
Grand average of hydropathy-0.337
Instability index39.63
Isoelectric point7.10
Molecular weight118789.54
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19652
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.28|      35|      93|     845|     879|       1
---------------------------------------------------------------------------
  845-  879 (61.93/39.92)	FDSIKFSYAPRLTCR....VRLSGEDTSPLLDFGLQGNT
  935-  973 (56.35/35.65)	FESREPVASSLLHCHnaldLRITYRAPLPILSFSINGRT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.45|      17|      91|     638|     727|       3
---------------------------------------------------------------------------
  638-  654 (28.83/37.73)	LGESK...DGRHI.ATLEALN
  729-  749 (19.62/47.20)	RSVSKsvaQGVHIfSNTGALD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     187.57|      68|      91|     413|     483|       6
---------------------------------------------------------------------------
  413-  481 (116.22/77.98)	IELGIGSGK..................QGSGTK...RK....PL...PQI....SCRWfRRGQ.EVTDHDLDFN.FTNISMEDMLEQVIAKHIS.GRLTALSAG
  508-  610 (71.36/37.54)	LRLGMRGTNtamtittdpirgaycvqpQSSATReieRRlnndPLvdaPAVlrfnICRQ.QLGQiEIRVRGLGLNrIDATSHKGSASQILREAVVfTTLQRLSWG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     145.36|      46|     552|     329|     375|       7
---------------------------------------------------------------------------
  329-  375 (77.29/55.91)	TTEFNNDRLRNQLEARM..NEVLATSGLDGCYNfLHNF..VLTHKLNVLRC
  882-  931 (68.07/43.91)	TDENPHASLRKQLETVFvpSDVFAPRTTLSSEK.LANFcqVLRATLSIIKC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.52|      17|      23|     224|     246|       9
---------------------------------------------------------------------------
  224-  246 (22.46/23.93)	PnPNIEGALELLSTgeapwMPDM
  250-  266 (31.06/14.00)	P.PKSLTAQELLDT.....LSDM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.44|      12|     550|     195|     223|      10
---------------------------------------------------------------------------
  179-  190 (23.84/14.41)	DWARN..MDDMSKL
  201-  214 (18.60/19.72)	DWATHgaADSIYRL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19652 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IRNLARQPTQPQTKPAQQAVQQPAPQRTASKTNKGRGQEVVVL
2) MPGRLVMDVKEPQGLGGLKRDGSHLSQQSEGREQKRVASDASRAKLNGAPLSPSGANTQADAPVINGVLHENNG
1033
1
1075
74










Molecular Recognition Features






MoRF SequenceStartStop




1) LGGLKRDG
15
22